2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Apolipoprotein Amyloid-β
  4. CS-6253

CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CS-6253

CS-6253 Chemical Structure

CAS No. : 1627911-44-7

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CS-6253:

CS-6253 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CS-6253

View All Apolipoprotein Isoform Specific Products:

View All Isoforms
apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease[1][2][3].

In Vitro

CS-6253 (1 μM; 45 min-24 h) increases the release of cholesterol-containing microvesicles in ABCA1-expressing BHK cells, which is positively correlated with high-density lipoprotein biogenesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CS-6253 Related Antibodies
In Vivo

CS-6253 (75-225 mg/kg; intravenous injection; once every other day; 5 times in total) transiently increases plasma triglycerides, apolipoprotein E, and Aβ42/40 ratio, while reducing high-density lipoprotein cholesterol and total cholesterol in cynomolgus monkeys[2].
CS-6253 (20 mg/kg; intraperitoneal injection; once every other day; 6 weeks) has improvement in a genetic risk model of Alzheimer’s disease[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male apoE4-targeted replacement mice aged 2.5 months old (25 g), in which the endogenous mouse apoE was replaced by either human apoE3 or apoE4[3]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; once every other day; 6 weeks
Result: Increased the lipidation level of apoE4.
Reversed apoE4-induced Aβ42 accumulation, tau hyperphosphorylation, synaptic damage, and cognitive deficits in hippocampal neurons.
Molecular Weight

3055.48

Formula

C136H228N36O43
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Glu-Val-{Cit}-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-{Cit}-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser
Sequence Shortening

EV-{Cit}-SKLEEWLAAL-{Cit}-ELAEELLARLKS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

0.5 M NaOH : ≥ 100 mg/mL (32.73 mM)

H2O : 33.33 mg/mL (10.91 mM; adjust pH to 10 with NaOH)

DMSO : 2 mg/mL (0.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3273 mL 1.6364 mL 3.2728 mL
5 mM 0.0655 mL 0.3273 mL 0.6546 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.5 M NaOH 1 mM 0.3273 mL 1.6364 mL 3.2728 mL 8.1820 mL
5 mM 0.0655 mL 0.3273 mL 0.6546 mL 1.6364 mL
10 mM 0.0327 mL 0.1636 mL 0.3273 mL 0.8182 mL
0.5 M NaOH 15 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.5455 mL
20 mM 0.0164 mL 0.0818 mL 0.1636 mL 0.4091 mL
25 mM 0.0131 mL 0.0655 mL 0.1309 mL 0.3273 mL
30 mM 0.0109 mL 0.0545 mL 0.1091 mL 0.2727 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CS-6253 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CS-62531627911-44-7CS6253CS 6253ApolipoproteinAmyloid-ββ-amyloid peptideAβAbetaAlzheimer's diseaseADatherosclerosis. BHK cellsInhibitorinhibitorinhibit

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