CS-6253
Based on 2 publication(s) in Google Scholar
CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease.
For research use only. We do not sell to patients.
- Purity: 98.84%
- CAS No.: 1627911-44-7
- Formula: C136H228N36O43
- Molecular Weight:3055.48
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CS-6253
More
Biological Activity
CS-6253 (1 μM; 45 min-24 h) increases the release of cholesterol-containing microvesicles in ABCA1-expressing BHK cells, which is positively correlated with high-density lipoprotein biogenesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CS-6253 (20 mg/kg; intraperitoneal injection; once every other day; 6 weeks) has improvement in a genetic risk model of Alzheimer’s disease[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male apoE4-targeted replacement mice aged 2.5 months old (25 g), in which the endogenous mouse apoE was replaced by either human apoE3 or apoE4[3]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection; once every other day; 6 weeks
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Result:Increased the lipidation level of apoE4.
Reversed apoE4-induced Aβ42 accumulation, tau hyperphosphorylation, synaptic damage, and cognitive deficits in hippocampal neurons.
Chemical Information
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CAS No. 1627911-44-7
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Appearance Solid
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Molecular Weight 3055.48
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Formula C136H228N36O43
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Color White to off-white
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Sequence
Glu-Val-{Cit}-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-{Cit}-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser
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Sequence Shortening
EV-{Cit}-SKLEEWLAAL-{Cit}-ELAEELLARLKS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Single-nucleus analysis reveals human-specific oligodendrocyte polarization and conserved neuronal responses after severe traumatic brain injury. [Abstract]2026 May 27. PMID: 42203771 -
Aging Cell
Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut-Liver Axis Homeostasis. [Abstract]2026 Mar;25(3):e70445. PMID: 41851037
Solvent & Solubility
0.5 M NaOH : ≥ 100 mg/mL (32.73 mM)
H2O : 33.33 mg/mL (10.91 mM; adjust pH to 10 with NaOH)
DMSO : 2 mg/mL (0.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hafiane A, et al. ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism. Can J Cardiol. 2019 Jun;35(6):770-781. [Content Brief]
[2]. Noveir SD, et al. Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys. Alzheimers Res Ther. 2022 Jun 24;14(1):87. [Content Brief]
[3]. Boehm-Cagan A, et al. ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. J Alzheimers Dis. 2016 Oct 4;54(3):1219-1233. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 0.5 M NaOH | 1 mM | 0.3273 mL | 1.6364 mL | 3.2728 mL | 8.1820 mL |
| 5 mM | 0.0655 mL | 0.3273 mL | 0.6546 mL | 1.6364 mL | |
| 10 mM | 0.0327 mL | 0.1636 mL | 0.3273 mL | 0.8182 mL | |
| 0.5 M NaOH | 15 mM | 0.0218 mL | 0.1091 mL | 0.2182 mL | 0.5455 mL |
| 20 mM | 0.0164 mL | 0.0818 mL | 0.1636 mL | 0.4091 mL | |
| 25 mM | 0.0131 mL | 0.0655 mL | 0.1309 mL | 0.3273 mL | |
| 30 mM | 0.0109 mL | 0.0545 mL | 0.1091 mL | 0.2727 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
CS-6253 Related Classifications
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