L685818 

L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans^[1][2].

L685818 (100 nM; 2 d for MPP+ group and 24 h for 6-OHDA group) showed neuroprotective effects, and the number of TH+ cells was increased under the inhibition of MPP+ and 6-OHDA^[1].
L685818 (10-100 nM; 24 h) protects against tyrosine hydroxylase (TH) loss caused by MPP+ and 6-OHDA (HY-B1081) treatments^[1].
L685818 (0.01-1μM; 2 d) significantly promotes the production of dopaminergic neurons by increasing the number of TH immunoreactive neuritis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

808.01

C₄₃H₆₉NO₁₃

143839-74-1

O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)[C@H](O)/C(C)=C/[C@H]3CC)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O

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• [1]. Guo X, et al. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci. 2001 May;13(9):1683-93.  [Content Brief]

  [2]. Odom A, et al. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother. 1997 Jan;41(1):156-61.  [Content Brief]