2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Reactive Oxygen Species (ROS) DNA/RNA Synthesis Interleukin Related
  4. Neuroprotective agent 16

Neuroprotective agent 16 is a blood-brain barrier-permeable neuroprotective agent. Neuroprotective agent 16 effectively scavenges DPPH and ABTS radicals, with IC50 values of 7.98 μM and 5.50 μM, respectively. Neuroprotective agent 16 exhibits anti-inflammatory, antioxidant, and DNA damage-reducing activities. Neuroprotective agent 16 can be used in research on diseases such as ischemic stroke.

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Neuroprotective agent 16

Neuroprotective agent 16 Chemical Structure

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Neuroprotective agent 16 Related Antibodies

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Description

Neuroprotective agent 16 is a blood-brain barrier-permeable neuroprotective agent. Neuroprotective agent 16 effectively scavenges DPPH and ABTS radicals, with IC50 values of 7.98 μM and 5.50 μM, respectively. Neuroprotective agent 16 exhibits anti-inflammatory, antioxidant, and DNA damage-reducing activities. Neuroprotective agent 16 can be used in research on diseases such as ischemic stroke[1].

IC50 & Target[1]

IL-17

 

In Vitro

Neuroprotective agent 16 (Compound B16) (0.1-10 μM; 24 h) protects SH-SY5Y cells against damage induced by tBHP and/or OGD/R[1].
Neuroprotective agent 16 (1 μM; 24 h) alleviates tBHP-induced cell cycle arrest and DNA damage in SH-SY5Y cells, scavenges excessive intracellular ROS, and maintains mitochondrial membrane potential[1].
Neuroprotective agent 16 (0.1-10 μM; 24 h) inhibits the secretion of TNF-α and IL-17 in tBHP-treated BV2 microglial cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroprotective agent 16 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y cell treated tBHP and/or OGD/R
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24 h
Result: Improved cell morphology and increased cell survival rates.

Cell Cycle Analysis[1]

Cell Line: SH-SY5Y cells treated tBHP
Concentration: 1 μM
Incubation Time: 24 h
Result: Reversed tBHP-induced G2/M phase arrest: increased S-phase cells from 1.49% to 6.97% and decreased G2/M-phase cells from 28.35% to 18.15%.
Significantly reduced intracellular γ-H2AX expression (a marker of DNA double-strand breaks) induced by tBHP.

ELISA Assay[1]

Cell Line: BV2 microglial cells treated tBHP
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24 h
Result: Caused a dose-dependent decrease in TNF-α and IL-17 expression levels in tBHP-stimulated BV2 cells.
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-t AUC0-∞ MRT0-∞
Mice[1] 10 mg/kg i.p. 20.6 h 0.08 h 30826.1 ng/mL 23999.8 ng·h/mL 34356.5 ng·h/mL 21.4 h
In Vivo

The neuroprotective agent 16 (Compound B16) (5-10 mg/kg; intraperitoneal injection; single dose) exhibits neuroprotective effects in MCAO/R mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 7 weeks old, 25-35 g, MCAO/R modeling)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.; single dose
Result: Reduced cerebral infarct volume significantly from 43.23% to 3.59% at 5 mg/kg.
Restored cerebral blood flow in the ischemic region, improved body weight recovery, and increased scores from balance beam, pole climbing, and corner tests.
Reduced perivascular white gaps and improved pyramidal cell morphology in hippocampal CA1 region and reduced neuronal edema/necrosis and preserved Nissl bodies. Significantly recovered Occludin and ZO-1 protein expression.
Molecular Weight

389.88

Formula

C20H24ClN3O3
SMILES

O=C(C1=NN(C(O)=C1)C2=C(C=C(C=N2)Cl)C)O[C@H]3C[C@H]4CC[C@@]3(C4(C)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neuroprotective agent 16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroprotective agent 16Neuroprotective agent16Neuroprotective agent-16Reactive Oxygen Species (ROS)DNA/RNA SynthesisInterleukin RelatedILSH-SY5Y cellsDPPHABTSmiceBV2 microglial cellsischemic strokeInhibitorinhibitorinhibit

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