2. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Monoamine Oxidase Reactive Oxygen Species (ROS) Cholinesterase (ChE) Interleukin Related
  4. MAO-A-IN-4

MAO-A-IN-4 is a highly selective and reversible inhibitor of monoamine oxidase A (MAO-A), with an IC50 of 0.06 μM against hMAO-A. MAO-A-IN-4 exhibits anti-inflammatory, antioxidant, neuroprotective, and antidepressant activities. MAO-A-IN-4 possesses favorable ADME properties and is suitable for research related to depression.

For research use only. We do not sell to patients.

MAO-A-IN-4

MAO-A-IN-4 Chemical Structure

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MAO-A-IN-4 Related Antibodies

Top Publications Citing Use of Products

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms
MAO-A MAO-B

View All Cholinesterase (ChE) Isoform Specific Products:

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AChE BChE

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

MAO-A-IN-4 is a highly selective and reversible inhibitor of monoamine oxidase A (MAO-A), with an IC50 of 0.06 μM against hMAO-A. MAO-A-IN-4 exhibits anti-inflammatory, antioxidant, neuroprotective, and antidepressant activities. MAO-A-IN-4 possesses favorable ADME properties and is suitable for research related to depression[1].

IC50 & Target[1]

hMAO-A

0.06 μM (IC50)

IL-6

 

AChE

 

In Vitro

MAO-A-IN-4 (Compound VK16) (10-100 μM; 30 min) exhibits concentration-dependent DPPH radical scavenging activity, with a scavenging rate of 77.12% at 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-A-IN-4 Related Antibodies
In Vivo

MAO-A-IN-4 (10-30 mg/kg; intraperitoneal administration) exhibits antidepressant effects in Reserpine (HY-N0480)-induced depressive mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (20-28 g, Reserpine-induced depression model)[1]
Dosage: 10, 30 mg/kg
Administration: i.p.
Result: Increased swimming time in the Forced swim test and decreased immobility time in the tail suspension test.
Increased brain dopamine levels and reduced acetylcholinesterase (AChE) levels.
Reduced oxidative stress parameters (TBARS levels) and restored antioxidant defenses (GSH and CAT activities).
Reduced pro-inflammatory cytokine (TNF-α, IL-6) levels.
Provided neuroprotection, with the 30 mg/kg dose restoring normal brain structures (cerebral cortex and hippocampus) similar to the control group.
Molecular Weight

489.63

Formula

C28H31N3O3S
SMILES

O=S(N1N=C(C2=CC=C(N3CCOCC3)C=C2)C[C@H]1C4=CC=C(CC)C=C4)(C5=CC=C(C)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-A-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-A-IN-4Monoamine OxidaseReactive Oxygen Species (ROS)Cholinesterase (ChE)Interleukin RelatedMAOILhMAO-Aforced swim testtail suspension testdepressed micedepressionInhibitorinhibitorinhibit

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