MAO-A-IN-4
MAO-A-IN-4 is a highly selective and reversible inhibitor of monoamine oxidase A (MAO-A), with an IC50 of 0.06 μM against hMAO-A. MAO-A-IN-4 exhibits anti-inflammatory, antioxidant, neuroprotective, and antidepressant activities. MAO-A-IN-4 possesses favorable ADME properties and is suitable for research related to depression.
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- Formule: C28H31N3O3S
- Masse moléculaire:489.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
hMAO-A 0.06 μM (IC50) |
IL-6 |
AChE |
In Vitro
MAO-A-IN-4 (Compound VK16) (10-100 μM; 30 min) exhibits concentration-dependent DPPH radical scavenging activity, with a scavenging rate of 77.12% at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (20-28 g, Reserpine-induced depression model)[1]
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Dosage:10, 30 mg/kg
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Administration:i.p.
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Result:Increased swimming time in the Forced swim test and decreased immobility time in the tail suspension test.
Increased brain dopamine levels and reduced acetylcholinesterase (AChE) levels.
Reduced oxidative stress parameters (TBARS levels) and restored antioxidant defenses (GSH and CAT activities).
Reduced pro-inflammatory cytokine (TNF-α, IL-6) levels.
Provided neuroprotection, with the 30 mg/kg dose restoring normal brain structures (cerebral cortex and hippocampus) similar to the control group.
Chemical Information
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Masse moléculaire 489.63
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Formule C28H31N3O3S
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SMILES
O=S(N1N=C(C2=CC=C(N3CCOCC3)C=C2)C[C@H]1C4=CC=C(CC)C=C4)(C5=CC=C(C)C=C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-A-IN-4 Related Classifications
HY-181110 Related Classifications
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