MAO-A-IN-4
MAO-A-IN-4 is a highly selective and reversible inhibitor of monoamine oxidase A (MAO-A), with an IC50 of 0.06 μM against hMAO-A. MAO-A-IN-4 exhibits anti-inflammatory, antioxidant, neuroprotective, and antidepressant activities. MAO-A-IN-4 possesses favorable ADME properties and is suitable for research related to depression.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C28H31N3O3S
- 分子量:489.63
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
hMAO-A 0.06 μM (IC50) |
IL-6 |
AChE |
体外実験
MAO-A-IN-4 (Compound VK16) (10-100 μM; 30 min) exhibits concentration-dependent DPPH radical scavenging activity, with a scavenging rate of 77.12% at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male mice (20-28 g, Reserpine-induced depression model)[1]
-
Dosage:10, 30 mg/kg
-
Administration:i.p.
-
Result:Increased swimming time in the Forced swim test and decreased immobility time in the tail suspension test.
Increased brain dopamine levels and reduced acetylcholinesterase (AChE) levels.
Reduced oxidative stress parameters (TBARS levels) and restored antioxidant defenses (GSH and CAT activities).
Reduced pro-inflammatory cytokine (TNF-α, IL-6) levels.
Provided neuroprotection, with the 30 mg/kg dose restoring normal brain structures (cerebral cortex and hippocampus) similar to the control group.
化学情報
-
分子量 489.63
-
分子式 C28H31N3O3S
-
SMILES
O=S(N1N=C(C2=CC=C(N3CCOCC3)C=C2)C[C@H]1C4=CC=C(CC)C=C4)(C5=CC=C(C)C=C5)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MAO-A-IN-4 関連分類
HY-181110 関連分類
Powered by Bioz