MAO-A-IN-4
MAO-A-IN-4 is a highly selective and reversible inhibitor of monoamine oxidase A (MAO-A), with an IC50 of 0.06 μM against hMAO-A. MAO-A-IN-4 exhibits anti-inflammatory, antioxidant, neuroprotective, and antidepressant activities. MAO-A-IN-4 possesses favorable ADME properties and is suitable for research related to depression.
For research use only. We do not sell to patients.
- Formula: C28H31N3O3S
- Molecular Weight:489.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hMAO-A 0.06 μM (IC50) |
IL-6 |
AChE |
MAO-A-IN-4 (Compound VK16) (10-100 μM; 30 min) exhibits concentration-dependent DPPH radical scavenging activity, with a scavenging rate of 77.12% at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (20-28 g, Reserpine-induced depression model)[1]
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Dosage:10, 30 mg/kg
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Administration:i.p.
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Result:Increased swimming time in the Forced swim test and decreased immobility time in the tail suspension test.
Increased brain dopamine levels and reduced acetylcholinesterase (AChE) levels.
Reduced oxidative stress parameters (TBARS levels) and restored antioxidant defenses (GSH and CAT activities).
Reduced pro-inflammatory cytokine (TNF-α, IL-6) levels.
Provided neuroprotection, with the 30 mg/kg dose restoring normal brain structures (cerebral cortex and hippocampus) similar to the control group.
Chemical Information
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Molecular Weight 489.63
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Formula C28H31N3O3S
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SMILES
O=S(N1N=C(C2=CC=C(N3CCOCC3)C=C2)C[C@H]1C4=CC=C(CC)C=C4)(C5=CC=C(C)C=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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