sTGFBR3 antagonist 1
sTGFBR3 antagonist 1 (Compound p24) is an antagonist for soluble transforming growth factor beta receptor 3 (sTGFBR3), thus activates TGF-β signaling pathway, and inhibits IκBα/NF-κB signaling pathway. sTGFBR3 antagonist 1 inhibits NO-release in LPS (HY-D1056) -induced BV2 cells with an IC50 of 0.52 μM. sTGFBR3 antagonist 1 exhibits anti-inflammatory and neuroprotective activities with blood brain barrier (BBB) permeability. sTGFBR3 antagonist 1 can be used in Alzheimer’s Disease research.
For research use only. We do not sell to patients.
- Formula: C21H21NO5
- Molecular Weight:367.40
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
0.52 μM
Compound: P24
|
Antiinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production incubated for 24 hrs by Griess reagent based analysis
Antiinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production incubated for 24 hrs by Griess reagent based analysis
|
[PMID: 39088998] |
Chemical Information
-
Molecular Weight 367.40
-
Formula C21H21NO5
-
SMILES
O=C1C2=C(C=C(OCC(NCC3CCOCC3)=O)C=C2)OC4=CC=CC=C41
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
sTGFBR3 antagonist 1 Related Classifications
HY-161925 Related Classifications
Powered by Bioz