1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Calycosin-7-O-β-D-glucoside

Calycosin-7-O-β-D-glucoside 

Cat. No.: HY-N0520 Purity: 98.71%
Handling Instructions

Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects.

For research use only. We do not sell to patients.

Calycosin-7-O-β-D-glucoside Chemical Structure

Calycosin-7-O-β-D-glucoside Chemical Structure

CAS No. : 20633-67-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects[1][2].

In Vitro

Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats[1]
Dosage: 26.8 mg/kg
Administration: Intraperitoneal injection; 26.8 mg/kg; 14 days
Result: Exhibited neuroprotective effects in rats.
Molecular Weight

446.40

Formula

C₂₂H₂₂O₁₀

CAS No.

20633-67-4

SMILES

O=C1C2=CC=C(O[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]3O)O)O[[email protected]@H]3CO)C=C2OC=C1C4=CC(O)=C(OC)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (224.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2401 mL 11.2007 mL 22.4014 mL
5 mM 0.4480 mL 2.2401 mL 4.4803 mL
10 mM 0.2240 mL 1.1201 mL 2.2401 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Calycosin-7-O-β-D-glucosideReactive Oxygen Speciescardioprotectionanti-inflammationantioxidative stressneuroprotectiveisoflavoneInhibitorinhibitorinhibit

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Product Name:
Calycosin-7-O-β-D-glucoside
Cat. No.:
HY-N0520
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