1. Stem Cell/Wnt
    TGF-beta/Smad
  2. TGF-beta/Smad
  3. SRI-011381

SRI-011381 

Cat. No.: HY-100347 Purity: 99.58%
Handling Instructions

SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

For research use only. We do not sell to patients.

SRI-011381 Chemical Structure

SRI-011381 Chemical Structure

CAS No. : 1629138-41-5

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 790 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of SRI-011381:

Top Publications Citing Use of Products

    SRI-011381 purchased from MCE. Usage Cited in: Life Sci. 2021 Aug 15;279:119359.

    The expression of pSmad2/3 in PBMCs treated with Curcumin or SRI-011381 (10 μM) detected by Western blot analysis normalized to GAPDH. SRI-011381 is found to up-regulate the phosphorylation of Smad2/3, while Curcumin reduces the activation of Smad2/3, whereas the inhibitory effect of curcumin in the activation of Smad2/3 is reversed by SRI-011381.

    SRI-011381 purchased from MCE. Usage Cited in: Mol Med Rep. 2021 Nov;24(5):758.

    Mimics-exo significantly inhibits the expression levels of TGF-β2 and p-Smad3, as well as downregulated the expression levels of Col-I, Col-III and α-SMA, while SRI-011381 hydrochloride (10 µM) reverses the inhibition of miR-29a-overexpressing hADSCs-exo on the activation of TGF-β2/Smad3 signaling and the fibrosis of HSFBs.
    • Biological Activity

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    • Customer Review

    Description

    SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

    In Vitro

    SRI-011381 (10 μM) promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2]
    Dosage: 30 mg/kg
    Administration: Intraperitoneally injection; every 2 d; for 22 days
    Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
    Molecular Weight

    329.48

    Formula

    C₂₀H₃₁N₃O

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (151.75 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0351 mL 15.1754 mL 30.3509 mL
    5 mM 0.6070 mL 3.0351 mL 6.0702 mL
    10 mM 0.3035 mL 1.5175 mL 3.0351 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    SRI-011381
    Cat. No.:
    HY-100347
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