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Cat. No.: HY-149268

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JNK3 inhibitor-6

JNK3 inhibitor-6 (Compound A53) is a selective JNK3 Inhibitor (IC₅₀=78 nM). JNK3 inhibitor-6 has neuroprotective effect, and can used for research of neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 3041063-63-9
Formula: C₂₄H₂₁Cl₂N₅O₃S
Molecular Weight:530.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

JNK3 inhibitor-6 Chemical Structure

CAS No.: 3041063-63-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JNK3 inhibitor-6 (Compound A53) is a selective JNK3 Inhibitor (IC₅₀=78 nM). JNK3 inhibitor-6 has neuroprotective effect, and can used for research of neurodegenerative diseases^[1].

IC₅₀ & Target

IC50: 78 nM (JNK3)^[1].

All JNK Isoforms :

Chemical Information

CAS No. 3041063-63-9
Molecular Weight 530.43
Formula C₂₄H₂₁Cl₂N₅O₃S
SMILES

CN1CCC(CC1)C(NC2=CC3=C(NC(/C3=C4S/C(NC\4=O)=N/C5=CC=CC(Cl)=C5Cl)=O)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Z, et al. The structure-based optimization of 3-substituted indolin-2-one derivatives as potent and isoform-selective c-Jun N-terminal kinase 3 (JNK3) inhibitors and biological evaluation. Eur J Med Chem. 2023 Mar 15;250:115167. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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JNK3 inhibitor-6

All JNK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNK3 inhibitor-6 Related Classifications

HY-149268 Related Classifications