J147
Based on 1 Customer Validation
J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD).
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 1807913-16-1
- Formula: C18H17F3N2O2
- Molecular Weight:350.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cerebral cortex neuron | EC50 |
0.033 μM
Compound: J147
|
Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay
Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay
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[PMID: 23582448] |
| Cortical neurone | EC50 |
25 nM
Compound: J147
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Neuroprotective activity against rat Primary cortical neuron cells assessed as rescue of cell death incubated for 2 days by fluorescent live-dead assay
Neuroprotective activity against rat Primary cortical neuron cells assessed as rescue of cell death incubated for 2 days by fluorescent live-dead assay
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[PMID: 32942072] |
| Hippocampal neurone | EC50 |
200 nM
Compound: J147
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Neuroprotective activity against amyloid beta induced cell death in rat Primary hippocampal neuron cells assessed as increase in cell viability incubated for 2 days by lactate dehydrogenase release assay
Neuroprotective activity against amyloid beta induced cell death in rat Primary hippocampal neuron cells assessed as increase in cell viability incubated for 2 days by lactate dehydrogenase release assay
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[PMID: 32942072] |
| HT-22 | EC50 |
0.02 μM
Compound: J147
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Neuroprotective activity in mouse HT22 cells assessed as reduction in glutamate-induced oxidative stress incubated for 30 mins prior to glutamate-challenge measured after 24 hrs by MTT assay
Neuroprotective activity in mouse HT22 cells assessed as reduction in glutamate-induced oxidative stress incubated for 30 mins prior to glutamate-challenge measured after 24 hrs by MTT assay
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[PMID: 23582448] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1807913-16-1
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Appearance Solid
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Molecular Weight 350.33
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Formula C18H17F3N2O2
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Color White to off-white
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SMILES
COC1=CC=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 40 mg/mL (114.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8545 mL | 14.2723 mL | 28.5445 mL | 71.3613 mL |
| 5 mM | 0.5709 mL | 2.8545 mL | 5.7089 mL | 14.2723 mL | |
| 10 mM | 0.2854 mL | 1.4272 mL | 2.8545 mL | 7.1361 mL | |
| 15 mM | 0.1903 mL | 0.9515 mL | 1.9030 mL | 4.7574 mL | |
| 20 mM | 0.1427 mL | 0.7136 mL | 1.4272 mL | 3.5681 mL | |
| 25 mM | 0.1142 mL | 0.5709 mL | 1.1418 mL | 2.8545 mL | |
| 30 mM | 0.0951 mL | 0.4757 mL | 0.9515 mL | 2.3787 mL | |
| 40 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7840 mL | |
| 50 mM | 0.0571 mL | 0.2854 mL | 0.5709 mL | 1.4272 mL | |
| 60 mM | 0.0476 mL | 0.2379 mL | 0.4757 mL | 1.1894 mL | |
| 80 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8920 mL | |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2854 mL | 0.7136 mL |
J147 Related Classifications
HY-13779A Related Classifications
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