J147

Cat. No.: HY-13779A Purity: 99.90%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

J147 Chemical Structure

CAS No. : 1807913-16-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of J147:

(E/Z)-J147 In-stock

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View All Isoforms

MAO-A MAO-B

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Cerebral cortex neuron	EC₅₀	0.033 μM Compound: J147	Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay	[PMID: 23582448]
Cortical neurone	EC₅₀	25 nM Compound: J147	Neuroprotective activity against rat Primary cortical neuron cells assessed as rescue of cell death incubated for 2 days by fluorescent live-dead assay Neuroprotective activity against rat Primary cortical neuron cells assessed as rescue of cell death incubated for 2 days by fluorescent live-dead assay	[PMID: 32942072]
HT-22	EC₅₀	0.02 μM Compound: J147	Neuroprotective activity in mouse HT22 cells assessed as reduction in glutamate-induced oxidative stress incubated for 30 mins prior to glutamate-challenge measured after 24 hrs by MTT assay Neuroprotective activity in mouse HT22 cells assessed as reduction in glutamate-induced oxidative stress incubated for 30 mins prior to glutamate-challenge measured after 24 hrs by MTT assay	[PMID: 23582448]
Hippocampal neurone	EC₅₀	200 nM Compound: J147	Neuroprotective activity against amyloid beta induced cell death in rat Primary hippocampal neuron cells assessed as increase in cell viability incubated for 2 days by lactate dehydrogenase release assay Neuroprotective activity against amyloid beta induced cell death in rat Primary hippocampal neuron cells assessed as increase in cell viability incubated for 2 days by lactate dehydrogenase release assay	[PMID: 32942072]

Clinical Trial

Molecular Weight

350.33

Formula

C₁₈H₁₇F₃N₂O₂

CAS No.

1807913-16-1

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 40 mg/mL (114.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8545 mL	14.2723 mL	28.5445 mL
5 mM	0.5709 mL	2.8545 mL	5.7089 mL
10 mM	0.2854 mL	1.4272 mL	2.8545 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Kyoungdo Kim, et al. Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem. 2015 Oct 7;13(37):9564-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8545 mL	14.2723 mL	28.5445 mL	71.3613 mL
	5 mM	0.5709 mL	2.8545 mL	5.7089 mL	14.2723 mL
	10 mM	0.2854 mL	1.4272 mL	2.8545 mL	7.1361 mL
	15 mM	0.1903 mL	0.9515 mL	1.9030 mL	4.7574 mL
	20 mM	0.1427 mL	0.7136 mL	1.4272 mL	3.5681 mL
	25 mM	0.1142 mL	0.5709 mL	1.1418 mL	2.8545 mL
	30 mM	0.0951 mL	0.4757 mL	0.9515 mL	2.3787 mL
	40 mM	0.0714 mL	0.3568 mL	0.7136 mL	1.7840 mL
	50 mM	0.0571 mL	0.2854 mL	0.5709 mL	1.4272 mL
	60 mM	0.0476 mL	0.2379 mL	0.4757 mL	1.1894 mL
	80 mM	0.0357 mL	0.1784 mL	0.3568 mL	0.8920 mL
	100 mM	0.0285 mL	0.1427 mL	0.2854 mL	0.7136 mL

J147 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

J1471807913-16-1J 147J-147Dopamine TransporterMonoamine OxidaseDATSLC6A3MAOBBBmonoamineoxidaseMAO BdopamineAlzheimer? diseaseneuroprotectiveInhibitorinhibitorinhibit

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J147

Customer Review

Other Forms of J147:

J147 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Monoamine Oxidase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

J147 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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