1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
    5-HT Receptor
    mAChR
  3. LY320135

LY320135 

Cat. No.: HY-W011040
Handling Instructions

LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect.

For research use only. We do not sell to patients.

LY320135 Chemical Structure

LY320135 Chemical Structure

CAS No. : 176977-56-3

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Description

LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect[1][2].

IC50 & Target[1]

CB1

141 nM (Ki)

5-HT2 Receptor

6.4 μM (Ki)

muscarinic receptor

2.1 μM (Ki)

CB2

>10 μM (Ki)

In Vitro

LY320135 has a relatively low affinity for the CB2 receptor (Ki=14.9±0.4 μM) and ten other unrelated receptors[1].
LY320135 (1 nM-10 μM) inhibits the anandamide-mediated forskolin-stimulated cAMP accumulation in CHO cell, with an IC50 of 734±122 nM[1].
LY320135 (0.1-1000 nM; 1-8 min) can reverse calcium current (ICa) inhibition by WIN 55212-2 in N18 cells, with an IC50 of 55±10 nM[1].
LY320135 (1 μM) prevents activation of Kir current by WIN 55212-2 in AtT-20-CB1 cells[1].
LY 320135 (0.001-1 μM) reduces CA1 injury induced by 20 min oxygen-glucose deprivation (OGD) in a concentration-dependent manner[2].

Molecular Weight

383.40

Formula

C₂₄H₁₇NO₄

CAS No.

176977-56-3

SMILES

N#CC1=CC=C(C(C2=C(C3=CC=C(OC)C=C3)OC4=CC(OC)=CC=C24)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LY320135LY 320135LY-320135Cannabinoid Receptor5-HT ReceptormAChRSerotonin Receptor5-hydroxytryptamine ReceptorMuscarinic acetylcholine receptorCB15-HT2muscarinicneuroprotectiveInhibitorinhibitorinhibit

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LY320135
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