176977-56-3
176977-56-3
Chemical Structure
LY320135
- CAS No.: 176977-56-3
- Formula:C24H17NO4
- Molecular Weight:383.40
IUPAC Name: 4-(6-methoxy-2-(4-methoxyphenyl)benzofuran-3-carbonyl)benzonitrile
InChIKey: RYNSGDFWBJWWSZ-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C(C2=C(C3=CC=C(OC)C=C3)OC4=CC(OC)=CC=C24)=O)C=C1
Biological Activity: LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect[1][2].
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LY320135 | LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect. | |||||||||||||||||||||
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References
- [1]. Felder CC, et, al. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan; 284(1):291-7. [Content Brief]
- [2]. Landucci E, et, al. CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices. Neuropharmacology. 2011 Mar; 60(4):674-82. [Content Brief]
Keywords
