2. Others Metabolic Enzyme/Protease Cytoskeleton Cell Cycle/DNA Damage
  3. Drug Derivative NAMPT Microtubule/Tubulin
  4. Carba1

Carba1 is a bifunctional Carbazole (HY-D0204) derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN).

For research use only. We do not sell to patients.

Carba1

Carba1 Chemical Structure

CAS No. : 2635394-10-2

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Carba1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Carba1 is a bifunctional Carbazole (HY-D0204) derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN)[1].

In Vitro

Carba1 (12 μM; 72 h) synergizes with Paclitaxel (HY-B0015), Docetaxel (HY-B0011), nab-Paclitaxel (HY-P99974), and Epothilone-B (HY-17029) to inhibit HeLa cell viability, reducing their GI50 values by 2.6, 3.8, 1.8 and 4.4 folds[1].
Carba1 (1-20 μM; 60 mins) enhances NAMPT activity in HeLa cells[1].
Carba1 (12 μM; 72 h) protects adult mouse DRG neurons from axonal degeneration induced by Paclitaxel, Cisplatin (HY-17394) and Bortezomib (HY-10227), reducing the degeneration index[1].
Carba1 (1-10 μM; 24 h) protects against Cisplatin-induced neurotoxicity and myelination impairment in rat DRG neurons[1].
Carba1 (12 μM, 2 h) regulates HeLa cell metabolism, increasing lactate, glutamate, ATP, and GTP levels, decreasing NAD+ levels, and enhancing glycolysis and glutaminolysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carba1 Related Antibodies
In Vivo

Carba1 (50 mg/kg; i.p.; on days 0, 1, 2, 4, 7, 9) prevents tactile allodynia and neurodegeneration in Paclitaxel-induced rats neuropathy model[1].
Carba1 (60 mg/kg; i.v.; every 2 days for 10 days) does not promote tumor growth and does not inhibit the antitumor activity of Paclitaxel in tumor growth modeling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Paclitaxel-induced rats neuropathy models[1]
Dosage: 50 mg/kg
Administration: Intraperitoneally injection; on days 0, 1, 2, 4, 7, 9
Result: Prevented tactile allodynia.
Reduced serum neurofilament light chain (NfL) levels.
Maintained intraepidermal nerve fiber (IENF) density.
Molecular Weight

294.78

Formula

C18H15ClN2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(N2C=CC=C2)=C(C)C3=C1NC4=C3C=C(Cl)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Carba1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carba12635394-10-2Carba 1Carba-1Drug DerivativeNAMPTMicrotubule/TubulinDrug derivativeNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorlactateglutamateATPGTPDRG neuronsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Carba1
Cat. No.:
HY-179523
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.