Carba1
Based on 1 Customer Validation
Carba1 is a bifunctional Carbazole (HY-D0204) derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN).
For research use only. We do not sell to patients.
- Purity: 98.23%
- CAS No.: 2635394-10-2
- Formula: C18H15ClN2
- Molecular Weight:294.78
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Glycolysis Compound Library
HY-L058
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Cytoskeleton Compound Library
HY-L060
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Neuroprotective Compound Library
HY-L070
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Anti-Lung Cancer Compound Library
HY-L075
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Metabolic Enzyme Compound Library
HY-L146
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Carba1 (12 μM; 72 h) synergizes with Paclitaxel (HY-B0015), Docetaxel (HY-B0011), nab-Paclitaxel (HY-P99974), and Epothilone-B (HY-17029) to inhibit HeLa cell viability, reducing their GI50 values by 2.6, 3.8, 1.8 and 4.4 folds[1].
Carba1 (1-20 μM; 60 mins) enhances NAMPT activity in HeLa cells[1].
Carba1 (12 μM; 72 h) protects adult mouse DRG neurons from axonal degeneration induced by Paclitaxel, Cisplatin (HY-17394) and Bortezomib (HY-10227), reducing the degeneration index[1].
Carba1 (1-10 μM; 24 h) protects against Cisplatin-induced neurotoxicity and myelination impairment in rat DRG neurons[1].
Carba1 (12 μM, 2 h) regulates HeLa cell metabolism, increasing lactate, glutamate, ATP, and GTP levels, decreasing NAD+ levels, and enhancing glycolysis and glutaminolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Carba1 (60 mg/kg; i.v.; every 2 days for 10 days) does not promote tumor growth and does not inhibit the antitumor activity of Paclitaxel in tumor growth modeling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Paclitaxel-induced rats neuropathy models[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneally injection; on days 0, 1, 2, 4, 7, 9
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Result:Prevented tactile allodynia.
Reduced serum neurofilament light chain (NfL) levels.
Maintained intraepidermal nerve fiber (IENF) density.
Chemical Information
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CAS No. 2635394-10-2
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Appearance Solid
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Molecular Weight 294.78
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Formula C18H15ClN2
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Color White to off-white
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SMILES
CC1=CC(N2C=CC=C2)=C(C)C3=C1NC4=C3C=C(Cl)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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