(E)-3-(4-Methoxyphenyl)acrylic acid
Based on 1 Customer Validation
(E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) is isolated from Arachis hypogaea, Scrophularia buergeriana Miquel, Aquilegia vulgaris, Anigozanthos preissii and so on. (E)-3-(4-Methoxyphenyl)acrylic acid shows significant hepatoprotective activity, anti-amnesic, cognition-enhancing activity, antihyperglycemic, and neuroprotective activities.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 943-89-5
- Formula: C10H10O3
- Molecular Weight:178.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>100 μM
Compound: PMOCA
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Antiproliferative activity against human HepG2 cells incubated for 72 hrs by CCK8 cells
Antiproliferative activity against human HepG2 cells incubated for 72 hrs by CCK8 cells
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[PMID: 31200238] |
| HepG2 | IC50 |
8.56 μM
Compound: PMOCA
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Antiproliferative activity against human HepG2 cells incubated for 72 hrs in presence of oridonin by CCK8 cells
Antiproliferative activity against human HepG2 cells incubated for 72 hrs in presence of oridonin by CCK8 cells
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[PMID: 31200238] |
| PLC-PRF-5 | IC50 |
>100 μM
Compound: PMOCA
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Antiproliferative activity against human PLC/PRF/5 cells incubated for 72 hrs by CCK8 cells
Antiproliferative activity against human PLC/PRF/5 cells incubated for 72 hrs by CCK8 cells
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[PMID: 31200238] |
| PLC-PRF-5 | IC50 |
6.55 μM
Compound: PMOCA
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Antiproliferative activity against human PLC/PRF/5 cells incubated for 72 hrs in presence of oridonin by CCK8 cells
Antiproliferative activity against human PLC/PRF/5 cells incubated for 72 hrs in presence of oridonin by CCK8 cells
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[PMID: 31200238] |
Chemical Information
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CAS No. 943-89-5
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Appearance Solid
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Molecular Weight 178.18
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Formula C10H10O3
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Color White to off-white
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SMILES
O=C(O)/C=C/C1=CC=C(OC)C=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (561.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.03 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6123 mL | 28.0615 mL | 56.1230 mL | 140.3076 mL |
| 5 mM | 1.1225 mL | 5.6123 mL | 11.2246 mL | 28.0615 mL | |
| 10 mM | 0.5612 mL | 2.8062 mL | 5.6123 mL | 14.0308 mL | |
| 15 mM | 0.3742 mL | 1.8708 mL | 3.7415 mL | 9.3538 mL | |
| 20 mM | 0.2806 mL | 1.4031 mL | 2.8062 mL | 7.0154 mL | |
| 25 mM | 0.2245 mL | 1.1225 mL | 2.2449 mL | 5.6123 mL | |
| 30 mM | 0.1871 mL | 0.9354 mL | 1.8708 mL | 4.6769 mL | |
| 40 mM | 0.1403 mL | 0.7015 mL | 1.4031 mL | 3.5077 mL | |
| 50 mM | 0.1122 mL | 0.5612 mL | 1.1225 mL | 2.8062 mL | |
| 60 mM | 0.0935 mL | 0.4677 mL | 0.9354 mL | 2.3385 mL | |
| 80 mM | 0.0702 mL | 0.3508 mL | 0.7015 mL | 1.7538 mL | |
| 100 mM | 0.0561 mL | 0.2806 mL | 0.5612 mL | 1.4031 mL |
(E)-3-(4-Methoxyphenyl)acrylic acid Related Classifications
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