HDAC1/MAO-B-IN-1
HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2759855-37-1
- Formula: C18H17ClN2O2
- Molecular Weight:328.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HDAC1 21.4 nM (IC50) |
MAO-B 99.0 nM (IC50) |
In Vitro
HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively[1].
HDAC1/MAO-B-IN-1 (50 µM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:PC12 cells
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Concentration:50 µM
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Incubation Time:24 h
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Result:Displayed neuroprotective and inhibitory activity on ROS production.
In Vivo
HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks, ICR male mice[1]
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Dosage:20 mg/kg
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Administration:I.g.
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Result:Exhibited favorable BBB (blood–brain barrier) permeability.
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Animal Model:20-25 g, ICR female mice[1]
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Dosage:15 mg/kg
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Administration:I.p.; 15 consecutive days
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Result:Improved the learning and memory abilities of the ICR mice.
Chemical Information
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CAS No. 2759855-37-1
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Molecular Weight 328.79
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Formula C18H17ClN2O2
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SMILES
C#CCN(CC1=CC(Cl)=CC=C1)CC2=CC=C(C=C2)C(NO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC1/MAO-B-IN-1 Related Classifications
HY-145845 Related Classifications
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