1. Cell Cycle/DNA Damage
    Epigenetics
    Neuronal Signaling
  2. HDAC
    Monoamine Oxidase
  3. HDAC1/MAO-B-IN-1

HDAC1/MAO-B-IN-1 

Cat. No.: HY-145845
Handling Instructions

HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

HDAC1/MAO-B-IN-1 Chemical Structure

HDAC1/MAO-B-IN-1 Chemical Structure

CAS No. : 2759855-37-1

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Description

HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1].

IC50 & Target[1]

HDAC1

21.4 nM (IC50)

MAO-B

99.0 nM (IC50)

In Vitro

HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively[1].
HDAC1/MAO-B-IN-1 (50 µM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 50 µM
Incubation Time: 24 h
Result: Displayed neuroprotective and inhibitory activity on ROS production.
In Vivo

HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability[1].
HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, ICR male mice[1]
Dosage: 20 mg/kg
Administration: I.g.
Result: Exhibited favorable BBB (blood–brain barrier) permeability.
Animal Model: 20-25 g, ICR female mice[1]
Dosage: 15 mg/kg
Administration: I.p.; 15 consecutive days
Result: Improved the learning and memory abilities of the ICR mice.
Molecular Weight

328.79

Formula

C18H17ClN2O2

CAS No.
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Storage

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Product Name:
HDAC1/MAO-B-IN-1
Cat. No.:
HY-145845
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