HDAC1/MAO-B-IN-1
HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2759855-37-1
- Formula: C18H17ClN2O2
- Molecular Weight:328.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC1 21.4 nM (IC50) |
MAO-B 99.0 nM (IC50) |
HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively[1].
HDAC1/MAO-B-IN-1 (50 µM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:50 µM
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Incubation Time:24 h
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Result:Displayed neuroprotective and inhibitory activity on ROS production.
HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks, ICR male mice[1]
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Dosage:20 mg/kg
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Administration:I.g.
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Result:Exhibited favorable BBB (blood–brain barrier) permeability.
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Animal Model:20-25 g, ICR female mice[1]
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Dosage:15 mg/kg
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Administration:I.p.; 15 consecutive days
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Result:Improved the learning and memory abilities of the ICR mice.
Chemical Information
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CAS No. 2759855-37-1
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Molecular Weight 328.79
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Formula C18H17ClN2O2
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SMILES
C#CCN(CC1=CC(Cl)=CC=C1)CC2=CC=C(C=C2)C(NO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC1/MAO-B-IN-1 Related Classifications
HY-145845 Related Classifications
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