Longistyline A
Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases.
For research use only. We do not sell to patients.
- CAS No.: 64095-60-9
- Formula: C20H22O2
- Molecular Weight:294.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 8.61 μg/mL (murine RAW264.7 cells)[2]
Longistyline A (4-16 μM/L; 48 h) reduces the corticosterone-induced neurotoxicity in PC12 cells[1]. Longistyline A can function as a membrane-targeting antibacterial agent by disturbing bacterial membrane potential and increasing the permeation[2]. Longistyline A (0-100 μg/mL) shows significant antimicrobial activity against tested Gram-positive bacteria, such as B.cereus CMCC63302 with MIC values of 25 μg/mL, S.aureus CMCC26003 with MIC values of 1.56 μg/mL, and both two strains of MRSA (JCSC4744 and JCSC4469) with MIC values of 1.56 μg/mL[2]. Longistyline A (24 h) shows cytotoxicity towards murine RAW264.7 cells with an IC50 value of 8.61 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PC12 cell line
-
Concentration:4, 8 and 16 μM/L
-
Incubation Time:48 hours
-
Result:Generated a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female wound healing BALB/c mice with MRSA infection[2]
-
Dosage:10 µg
-
Administration:Apply to the wound; 10 µg dissolved in 50 µL PBS buffer; 5 min after infection for 30 min
-
Result:Showed a wound healing efficiency and significantly alleviated weight loss induced by MRSA infection. Reduced gram-positive microorganisms in vivo with a better effect than vancomycin. Reduced accumulation of immune cells at the injury site and alleviated induction of TNF-α and IL-6 in serum.
Chemical Information
-
CAS No. 64095-60-9
-
Molecular Weight 294.39
-
Formula C20H22O2
-
SMILES
COC1=C(C(O)=CC(/C=C/C2=CC=CC=C2)=C1)C/C=C(C)\C
-
Synonyms
Longistylin A
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jiang BP, et al. [Neuroprotective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells]. Yao Xue Xue Bao. 2012 May;47(5):600-3. [Content Brief]
[2]. Wu J, et al. Longistylin A, a natural stilbene isolated from the leaves of Cajanus cajan, exhibits significant anti-MRSA activity. Int J Antimicrob Agents. 2020 Jan;55(1):105821. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Longistyline A Related Classifications
HY-N9690 Related Classifications
Powered by Bioz