2. Anti-infection
  3. Bacterial
  4. Longistyline A

Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases.

For research use only. We do not sell to patients.

Longistyline A Chemical Structure

Longistyline A Chemical Structure

CAS No. : 64095-60-9

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Longistyline A Related Antibodies

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Description

Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases[1][2].

IC50 & Target

IC50: 8.61 μg/mL (murine RAW264.7 cells)[2]
In Vitro

Longistyline A (4-16 μM/L; 48 h) reduces the corticosterone-induced neurotoxicity in PC12 cells[1].
Longistyline A can function as a membrane-targeting antibacterial agent by disturbing bacterial membrane potential and increasing the permeation[2].
Longistyline A (0-100 μg/mL) shows significant antimicrobial activity against tested Gram-positive bacteria, such as B.cereus CMCC63302 with MIC values of 25 μg/mL, S.aureus CMCC26003 with MIC values of 1.56 μg/mL, and both two strains of MRSA (JCSC4744 and JCSC4469) with MIC values of 1.56 μg/mL[2].
Longistyline A (24 h) shows cytotoxicity towards murine RAW264.7 cells with an IC50 value of 8.61 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Longistyline A Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: PC12 cell line
Concentration: 4, 8 and 16 μM/L
Incubation Time: 48 hours
Result: Generated a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity.
In Vivo

Longistyline A (10 µg dissolved in 50 µL PBS buffer; apply to the wound; for 30 min) improves wound healing, decreases MRSA bacterial survivals in the lesions and reduces inflammatory reaction in MRSA infected mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female wound healing BALB/c mice with MRSA infection[2]
Dosage: 10 µg
Administration: Apply to the wound; 10 µg dissolved in 50 µL PBS buffer; 5 min after infection for 30 min
Result: Showed a wound healing efficiency and significantly alleviated weight loss induced by MRSA infection. Reduced gram-positive microorganisms in vivo with a better effect than vancomycin. Reduced accumulation of immune cells at the injury site and alleviated induction of TNF-α and IL-6 in serum.
Molecular Weight

294.39

Formula

C20H22O2
CAS No.
SMILES

COC1=C(C(O)=CC(/C=C/C2=CC=CC=C2)=C1)C/C=C(C)\C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Longistyline A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Longistyline A64095-60-9Longistylin ABacterialstilbeneB. cereusS.aureusMRSAneuroprotectiveinfectionPC12RAW264.7Inhibitorinhibitorinhibit

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