JNK3 inhibitor-7
JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD).
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- CAS No.: 3034676-52-0
- 화학식: C32H31N7O3
- 분자량:561.63
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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JNK3 53 nM (IC50) |
JNK2 973 nM (IC50) |
JNK1 1039 nM (IC50) |
JNK3 inhibitor-7 (compound 2h; 20 µM; 24, 48 h) increases primary rat cortex neuron cell viability when treatment with 10 μM amyloid-β1-42[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:primary rat cortex neuron cells
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Concentration:20 µM
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Incubation Time:24, 48 h
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Result:Increased cell viability when treatment with 10 μM amyloid-β1-42.
Pharmacokinetic Parameters of JNK3 inhibitor-7 in Sprague-Dawley rats[1].
| compound | 2h |
| admin. | PO |
| dose (mg/kg) | 3 |
| AUClast (h ng/ml) | 350.68 |
| C0 or Cmax (ng/mL) | 342.30 |
| Tmax (h) | 0.39 |
| T1/2 (h) | 0.65 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:7 month-old APP/PS1 AD mice[1]
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Dosage:30, 60 mg/kg
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Administration:P.o.; daily for 4 weeks
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Result:Decreased the escape time and distance traveled, a dose-dependent increased in the quadrant where the escape zone was located and the time spent.
Chemical Information
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CAS No. 3034676-52-0
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분자량 561.63
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화학식 C32H31N7O3
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SMILES
CNC(OC1=CC=C2N=C(C3=CC4=C(C=CC=C4)C=C3)N(C5=NC(N[C@@H]6CN(CCC6)C(C7CC7)=O)=NC=C5)C2=C1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK3 inhibitor-7 Related Classifications
HY-149279 Related Classifications
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