3034676-52-0
Chemical Structure
JNK3 inhibitor-7
- CAS No.: 3034676-52-0
- Formula:C32H31N7O3
- Molecular Weight:561.63
IUPAC Name: (S)-1-(2-((1-(cyclopropanecarbonyl)piperidin-3-yl)amino)pyrimidin-4-yl)-2-(naphthalen-2-yl)-1H-benzo[d]imidazol-6-yl methylcarbamate
InChIKey: UVXXVTKNDYEVAL-DEOSSOPVSA-N
SMILES: CNC(OC1=CC=C2N=C(C3=CC4=C(C=CC=C4)C=C3)N(C5=NC(N[C@@H]6CN(CCC6)C(C7CC7)=O)=NC=C5)C2=C1)=O
Biological Activity: JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD)[1].
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JNK3 inhibitor-7 | JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD). | |||||||||||||||||||||
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Keywords
