1. NF-κB
    Stem Cell/Wnt
    MAPK/ERK Pathway
    PI3K/Akt/mTOR
    Metabolic Enzyme/Protease
    Immunology/Inflammation
  2. Keap1-Nrf2
    ERK
    Akt
    JNK
    Reactive Oxygen Species
  3. Nrf2/HO-1 activator 1

Nrf2/HO-1 activator 1 

Cat. No.: HY-151430
Handling Instructions

Nrf2/HO-1 activator 1 (Compound 24) is a potent Nrf2/HO-1 activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research.

For research use only. We do not sell to patients.

Nrf2/HO-1 activator 1 Chemical Structure

Nrf2/HO-1 activator 1 Chemical Structure

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Description

Nrf2/HO-1 activator 1 (Compound 24) is a potent Nrf2/HO-1 activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research[1].

In Vitro

Nrf2/HO-1 activator 1 (0.3-30 µM; 24 h) exhibits potent neuroprotection in both 6-OHDA- and rotenone-induced cell death models[1].
Nrf2/HO-1 activator 1 (1-30 µM; 6 h) increases HO-1 expression in PC12 cells[1].
Nrf2/HO-1 activator 1 (12 µM; 1-12 h) increases phosphorylation of ERK1/2, JNK, and Akt in PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 0.3, 1, 3, 10, and 30 μM
Incubation Time: 4 hours
Result: Inhibited 6-OHDA-induced toxicity with IC50 of 3.9 μM.
Inhibited rotenone-induced toxicity with IC50 of 4.8 μM.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 10 μM
Incubation Time: 1, 3, 6, and 12 hours
Result: Induced phosphorylation of ERK1/2, JNK, and Akt.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 1, 3, 10, and 30 μM
Incubation Time: 6 hours
Result: Increased HO-1 expression in a dose-dependent manner, with 2-fold increases at 30 μM concentrations.
In Vivo

Nrf2/HO-1 activator 1 inhibits the production of lipid peroxide in rat brain homogenates by 50.5% at 100 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.36

Formula

C21H18O5

SMILES

O=C1C(C2=CC=C(OC)C=C2)=COC3=C1C4=C(C=CC(C)(C)O4)C(O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Nrf2/HO-1 activator 1
Cat. No.:
HY-151430
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