Nrf2/HO-1 activator 1
Based on 1 publication(s) in Google Scholar
Nrf2/HO-1 activator 1 (Compound 24) is a potent Nrf2/HO-1 activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research.
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- 화학식: C21H18O5
- 분자량:350.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Nrf2/HO-1 activator 1
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | IC50 |
3.9 μM
Compound: 24
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Cytotoxicity in rat PC-12 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity in rat PC-12 cells assessed as cell viability incubated for 24 hrs by MTT assay
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[PMID: 36029560] |
| PC-12 | IC50 |
4.8 μM
Compound: 24
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Neurotoxicity in rotenone induced at rat PC-12 cells assessed as cell viability pretreated with compound for 4 hrs followed by rotenone addition measured after 24 hrs by MTT assay
Neurotoxicity in rotenone induced at rat PC-12 cells assessed as cell viability pretreated with compound for 4 hrs followed by rotenone addition measured after 24 hrs by MTT assay
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[PMID: 36029560] |
Nrf2/HO-1 activator 1 (0.3-30 µM; 24 h) exhibits potent neuroprotection in both 6-OHDA- and rotenone-induced cell death models[1].
Nrf2/HO-1 activator 1 (1-30 µM; 6 h) increases HO-1 expression in PC12 cells[1].
Nrf2/HO-1 activator 1 (12 µM; 1-12 h) increases phosphorylation of ERK1/2, JNK, and Akt in PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:0.3, 1, 3, 10, and 30 μM
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Incubation Time:4 hours
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Result:Inhibited 6-OHDA-induced toxicity with IC50 of 3.9 μM.
Inhibited rotenone-induced toxicity with IC50 of 4.8 μM.
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Cell Line:PC12 cells
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Concentration:10 μM
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Incubation Time:1, 3, 6, and 12 hours
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Result:Induced phosphorylation of ERK1/2, JNK, and Akt.
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Cell Line:PC12 cells
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Concentration:1, 3, 10, and 30 μM
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Incubation Time:6 hours
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Result:Increased HO-1 expression in a dose-dependent manner, with 2-fold increases at 30 μM concentrations.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 350.36
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화학식 C21H18O5
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SMILES
O=C1C(C2=CC=C(OC)C=C2)=COC3=C1C4=C(C=CC(C)(C)O4)C(O)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nrf2/HO-1 activator 1 Related Classifications
HY-151430 Related Classifications
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