2. Others Apoptosis NF-κB MAPK/ERK Pathway Stem Cell/Wnt
  3. Drug Derivative Apoptosis Keap1-Nrf2 Raf MEK ERK
  4. NEPP11

NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion.

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NEPP11

NEPP11 Chemical Structure

CAS No. : 313051-12-6

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NEPP11 Related Antibodies

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B-Raf C-Raf Raf

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

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ERK ERK1 ERK2 ERK5 ERK8

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Description

NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion[1].

IC50 & Target[1]

ERK1

 

ERK2

 

MEK1

 

MEK2

 

C-Raf

 

Molecular Weight

396.57

Formula

C26H36O3
CAS No.
SMILES

C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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NEPP11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NEPP11313051-12-6NEPP 11NEPP-11Drug DerivativeApoptosisKeap1-Nrf2RafMEKERKDrug derivativeRaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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