NEPP11
NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion.
For research use only. We do not sell to patients.
- CAS No.: 313051-12-6
- Formula: C26H36O3
- Molecular Weight:396.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
|
ERK1 |
ERK2 |
MEK1 |
MEK2 |
C-Raf |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | Inhibition |
50 %
Compound: 1, NEPP11
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Inhibition of manganese ion-induced apoptosis in PC12 cells assessesed as suppression of DNA fragmentation at 10 uM
Inhibition of manganese ion-induced apoptosis in PC12 cells assessesed as suppression of DNA fragmentation at 10 uM
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[PMID: 17706424] |
Chemical Information
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CAS No. 313051-12-6
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Molecular Weight 396.57
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Formula C26H36O3
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SMILES
C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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