313051-12-6
Chemical Structure
NEPP11
- CAS No.: 313051-12-6
- Formula:C26H36O3
- Molecular Weight:396.57
IUPAC Name: methyl (R,E)-7-(2-oxo-5-(6-(p-tolyl)hexyl)cyclopent-3-en-1-ylidene)heptanoate
InChIKey: RHQDOVRJBSRATA-HPTBBYBNSA-N
SMILES: C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2
Biological Activity: NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion[1].
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NEPP11 | NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion. | |||||||||||||||||||||
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