1. MAPK/ERK Pathway Apoptosis Stem Cell/Wnt PI3K/Akt/mTOR
  2. JNK Apoptosis GSK-3 p38 MAPK
  3. JNK3 inhibitor-5

JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable.

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JNK3 inhibitor-5 Chemical Structure

JNK3 inhibitor-5 Chemical Structure

CAS No. : 2911640-63-4

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Description

JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable[1].

IC50 & Target[1]

JNK3

0.379 nM (IC50)

JNK2

29.4 nM (IC50)

JNK1

82.7 nM (IC50)

p38α

215.8 nM (IC50)

GSK-3β

3889.7 nM (IC50)

In Vitro

JNK3 inhibitor-5 (Compound 22b) (10 μM; 24 h) shows neuroprotective effects against amyloid beta-induced apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Primary rat cortical neurons
Concentration: 10 μM
Incubation Time: Pre-treated for 90 min, followed by treatment with 10 μM Aβ42 (HIFP-treated) for 24 h on day 5 of differentiation
Result: Showed excellent neuroprotective effect.

Western Blot Analysis[1]

Cell Line: Primary rat cortical neurons
Concentration: 10 μM
Incubation Time: 90 min
Result: Highly mitigated Aβ1-42-induced c-Jun phosphorylation.
Molecular Weight

540.44

Formula

C26H27Cl2N7O2

CAS No.
SMILES

NC(C1CC2=C(C1)N=C(C3=CC(Cl)=C(C=C3)Cl)N2C4=NC(N[C@@H]5CN(CCC5)C(C6CC6)=O)=NC=C4)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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JNK3 inhibitor-5
Cat. No.:
HY-151962
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