JNK3 inhibitor-5
JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable.
For research use only. We do not sell to patients.
- CAS No.: 2911640-63-4
- Formula: C26H27Cl2N7O2
- Molecular Weight:540.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JNK3 0.379 nM (IC50) |
JNK2 29.4 nM (IC50) |
JNK1 82.7 nM (IC50) |
p38α 215.8 nM (IC50) |
GSK-3β 3889.7 nM (IC50) |
JNK3 inhibitor-5 (Compound 22b) (10 μM; 24 h) shows neuroprotective effects against amyloid beta-induced apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary rat cortical neurons
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Concentration:10 μM
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Incubation Time:Pre-treated for 90 min, followed by treatment with 10 μM Aβ42 (HIFP-treated) for 24 h on day 5 of differentiation
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Result:Showed excellent neuroprotective effect.
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Cell Line:Primary rat cortical neurons
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Concentration:10 μM
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Incubation Time:90 min
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Result:Highly mitigated Aβ1-42-induced c-Jun phosphorylation.
Chemical Information
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CAS No. 2911640-63-4
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Molecular Weight 540.44
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Formula C26H27Cl2N7O2
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SMILES
NC(C1CC2=C(C1)N=C(C3=CC(Cl)=C(C=C3)Cl)N2C4=NC(N[C@@H]5CN(CCC5)C(C6CC6)=O)=NC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK3 inhibitor-5 Related Classifications
HY-151962 Related Classifications
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