2911640-63-4
Chemical Structure
JNK3 inhibitor-5
- CAS No.: 2911640-63-4
- Formula:C26H27Cl2N7O2
- Molecular Weight:540.44
IUPAC Name: 1-(2-(((S)-1-(cyclopropanecarbonyl)piperidin-3-yl)amino)pyrimidin-4-yl)-2-(3,4-dichlorophenyl)-1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide
InChIKey: MKHLHLAXBRMALM-DJNXLDHESA-N
SMILES: NC(C1CC2=C(C1)N=C(C3=CC(Cl)=C(C=C3)Cl)N2C4=NC(N[C@@H]5CN(CCC5)C(C6CC6)=O)=NC=C4)=O
Biological Activity: JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable[1].
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JNK3 inhibitor-5 | JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable. | |||||||||||||||||||||
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