1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

Ibudilast (Synonyms: KC-404; AV-411; MN-166)

Cat. No.: HY-B0763 Purity: 99.89%
Handling Instructions

Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma.

For research use only. We do not sell to patients.

Ibudilast Chemical Structure

Ibudilast Chemical Structure

CAS No. : 50847-11-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 42 In-stock
Estimated Time of Arrival: December 31
50 mg USD 59 In-stock
Estimated Time of Arrival: December 31
100 mg USD 92 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

    Ibudilast purchased from MCE. Usage Cited in: Photochem Photobiol. 2016 Nov;92(6):816-825.

    Western blot analysis reveals that Resatorvid-based inhibition of TLR4 is able to block UV-induced phosphorylation of MAP kinases (p38 and JNK) and Akt.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma. Target: PDE Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE). The inhibition of platelet aggregation and vasodilatation by ibudilast may be due to synergistic elevation of intracellular cyclic nucleotides and release of nitric oxide (NO) or prostacyclin from endothelium, rather than direct inhibition of PDE5 or PDE3. Another important property of ibudilast is its antiinflammatory activity possibly associated with potent inhibition of PDE4. Combined with its relaxing effects on bronchial smooth muscle, antiinflammatory actvity of ibudilast could favorably influence pathophysiology of asthma by antagonizing chemical mediators triggering asthmatic attacks [1, 2]. Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation. Preclinical data indicate that ibudilast crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain, with a novel mechanism of action [3].

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : 150 mg/mL (651.30 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3420 mL 21.7099 mL 43.4197 mL
    5 mM 0.8684 mL 4.3420 mL 8.6839 mL
    10 mM 0.4342 mL 2.1710 mL 4.3420 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.85 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.85 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.85 mM); Clear solution

    References
    Molecular Weight

    230.31

    Formula

    C₁₄H₁₈N₂O

    CAS No.

    50847-11-5

    SMILES

    CC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.89%

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Ibudilast
    Cat. No.:
    HY-B0763
    Quantity:

    Ibudilast

    Cat. No.: HY-B0763