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  3. PPAR
  4. Amorfrutin B

Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities.

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Amorfrutin B Chemical Structure

Amorfrutin B Chemical Structure

CAS No. : 78916-42-4

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Amorfrutin B Related Antibodies

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Description

Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities[1][2].

In Vitro

Amorfrutin B (1,5 μM, 6 h) inhibits apoptosis and autophagy by gene methylation and miRNA-dependent regulation, and protects mouse brain neurons from hypoxia/ischemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amorfrutin B Related Antibodies
In Vivo

Amorfrutin B (100 mg/kg, added to food for 2 weeks) improves insulin sensitivity, glucose tolerance and lipid concentration in insulin-resistant mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet mice model[2].
Dosage: 100 mg/kg
Administration: Add to food，2 weeks
Result: Reduced fasting plasma levels of triacylglycerols by 25% and the concentrations of deleterious plasma NEFA by 29%.
Molecular Weight

408.53

Formula

C26H32O4
CAS No.
SMILES

O=C(O)C1=C(CCC2=CC=CC=C2)C=C(OC)C(C/C=C(C)/CC/C=C(C)\C)=C1O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Amorfrutin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amorfrutin B78916-42-4PPARPeroxisome proliferator-activated receptorsPPARγHFDHypoglycemicNeuroprotectiveInhibitorinhibitorinhibit

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