Musk ketone
Based on 1 publication(s) in Google Scholar
Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 81-14-1
- Formula: C14H18N2O5
- Molecular Weight:294.31
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Metabolism/Protease Compound Library
HY-L012
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PI3K/Akt/mTOR Compound Library
HY-L015
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Stem Cell Signaling Compound Library
HY-L017
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Autophagy Compound Library
HY-L029
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Anti-Aging Compound Library
HY-L034
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Antioxidant Compound Library
HY-L037
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Reprogramming Compound Library
HY-L039
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Oxygen Sensing Compound Library
HY-L045
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Glycolysis Compound Library
HY-L058
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Cytoskeleton Compound Library
HY-L060
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Glutamine Metabolism Compound Library
HY-L064
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Neuroprotective Compound Library
HY-L070
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Cancer Metabolism Compound Library
HY-L083
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Angiogenesis-Related Compound Library
HY-L088
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Mitochondria-Targeted Compound Library
HY-L089
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Glucose Metabolism Compound Library
HY-L092
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Food Additive Library
HY-L093
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Antidepressant Compound Library
HY-L108
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Human Metabolite Library
HY-L123
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Pain-Related Compound Library
HY-L139
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Mitochondrial Protection Compound Library
HY-L144
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Metabolic Enzyme Compound Library
HY-L146
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Membrane Protein-targeted Compound Library
HY-L149
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Cell Death Library
HY-L162
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Multi-Target Compound Library
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HY-L001V
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HY-L199
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HY-L201
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HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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Cosmetic Ingredient Compound Library
HY-L221
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Flavors and Fragrances Compound Library
HY-L242
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HY-L247
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Lactylation Compound Library
HY-L249
Publications Citing Use of MedChemExpress (MCE) Musk ketone
More
Biological Activity
Musk ketone (0.9 and 1.8 μM) enhances proliferation and differentiation in neural stem cells (NSCs), along with increased PI3K/Akt signaling pathway activation[3].
Musk ketone (0-100 μM, 48 h) inhibits the cell viability of GC cells, with IC50s of 4.2 µM for AGS cells and 10.06 µM for HGC-27 cells, and inhibits colonies formation[5].
Musk ketone (4.2 µM for AGS, 10.06 µM for HGC-27; 48 h) induces cell cycle arrest and apoptosis in AGS and HGC-27 cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AGS, HGC-27
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Concentration:4.2 µM for AGS, 10.06 µM for HGC-27
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Incubation Time:48 h
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Result:Increased ratio of Cle-caspase 3 to caspase 3 protein level.
Induced cell apoptosis, detected by PI/Annexin V staining;
Musk ketone (20-200 mg/kg, p.o., 7 days) increases CYP2B activity, protein and mRNA levels, and increases CYP1A enzyme activity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 81-14-1
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Appearance Solid
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Molecular Weight 294.31
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Formula C14H18N2O5
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Color White to off-white
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SMILES
CC(C1=C(C)C([N+]([O-])=O)=C(C(C)(C)C)C([N+]([O-])=O)=C1C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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CNS Neurosci Ther
Tongqiao Huoxue Decoction ameliorates traumatic brain injury-induced gastrointestinal dysfunction by regulating CD36/15-LO/NR4A1 signaling, which fails when CD36 and CX3CR1 are deficient. [Abstract]2023 Jun;29 Suppl 1(Suppl 1):161-184. PMID: 37157929
Solvent & Solubility
DMSO : ≥ 125 mg/mL (424.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (915 KB)
- English - EN (915 KB)
- Français - FR (915 KB)
- Deutsch - DE (915 KB)
- Norwegian - NO (915 KB)
- Español - ES (915 KB)
- Swedish - SV (915 KB)
- Italian - IT (915 KB)
- Korean - KR (915 KB)
- Portuguese - PT (915 KB)
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Handling Instructions (2659 KB)
References
[1]. Yamagishi T, et al. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull Environ Contam Toxicol. 1981 May;26(5):656-62. [Content Brief]
[2]. Mersch-Sundermann V, et al. Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells. Mutat Res. 2001 Aug 22;495(1-2):89-96. [Content Brief]
[3]. Zhou Z, et al. Musk Ketone Induces Neural Stem Cell Proliferation and Differentiation in Cerebral Ischemia via Activation of the PI3K/Akt Signaling Pathway. Neuroscience. 2020 May 21;435:1-9. [Content Brief]
[4]. Lehman-McKeeman LD, et al. Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes. Toxicol Lett. 1999 Dec 20;111(1-2):105-15. [Content Brief]
[5]. An J, et al. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2. Mol Med Rep. 2021 Jun;23(6):450. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3978 mL | 16.9889 mL | 33.9778 mL | 84.9444 mL |
| 5 mM | 0.6796 mL | 3.3978 mL | 6.7956 mL | 16.9889 mL | |
| 10 mM | 0.3398 mL | 1.6989 mL | 3.3978 mL | 8.4944 mL | |
| 15 mM | 0.2265 mL | 1.1326 mL | 2.2652 mL | 5.6630 mL | |
| 20 mM | 0.1699 mL | 0.8494 mL | 1.6989 mL | 4.2472 mL | |
| 25 mM | 0.1359 mL | 0.6796 mL | 1.3591 mL | 3.3978 mL | |
| 30 mM | 0.1133 mL | 0.5663 mL | 1.1326 mL | 2.8315 mL | |
| 40 mM | 0.0849 mL | 0.4247 mL | 0.8494 mL | 2.1236 mL | |
| 50 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6989 mL | |
| 60 mM | 0.0566 mL | 0.2831 mL | 0.5663 mL | 1.4157 mL | |
| 80 mM | 0.0425 mL | 0.2124 mL | 0.4247 mL | 1.0618 mL | |
| 100 mM | 0.0340 mL | 0.1699 mL | 0.3398 mL | 0.8494 mL |
Musk ketone Related Classifications
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