MAO-B-IN-39
MAO-B-IN-39 (compound11) is a selective monoamine oxidase B (MAO-B) inhibitor. MAO-B-IN-39 inhibits MAO-Bwith an IC50 of 3.61 μM. MAO-B-IN-39 demonstrates a potent NRF2 induction capacity. MAO-B-IN-39 exhibits potent anti-inflammatory and neuroprotective activity in OS (oxidative stress)-related in vitro models. MAO-B-IN-39 demonstrates high liver microsomal stability and favorable pharmacokinetics in mice. MAO-B-IN-39 is potential for Parkinson’s disease (PD) research.
For research use only. We do not sell to patients.
- CAS No.: 3094045-97-0
- Formula: C17H13FN2O
- Molecular Weight:280.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-B 3.61 μM (IC50) |
MAO-A >30 μM (IC50) |
Chemical Information
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CAS No. 3094045-97-0
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Molecular Weight 280.30
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Formula C17H13FN2O
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SMILES
O=C(NC1=CC=C2NC=CC2=C1)/C=C/C3=C(C=CC=C3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhang C, et al. Design, Synthesis, and Biological Evaluation of Chiral-Proline Derivatives as Novel HSP90 Inhibitors. ACS Med Chem Lett. 2025 Jan 22;16(2):301-310. [Content Brief]
[2]. Duarte P, et al. Network-Based Drug Optimization toward the Treatment of Parkinson's Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation. J Med Chem. 2025 Feb 13;68(3):3495-3517. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-39 Related Classifications
HY-170887 Related Classifications
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