Nrf2 activator 19
Nrf2 activator 19 is a BBB-penetrable NRF2/HO-1 activator. Nrf2 activator 19 exerts potent antioxidant and neuroprotective effects. Nrf2 activator 19 can also effectively reduce brain damage, reduce Reactive Oxygen Species (ROS) accumulation. Nrf2 activator 19 inhibits neuronal apoptosis. Nrf2 activator 19 promotes the recovery of neurological function and motor ability. Nrf2 activator 19 shows significant potential in ischemic stroke research.
For research use only. We do not sell to patients.
- Formula: C25H20O5
- Molecular Weight:400.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Nrf2 activator 19 (Compound 6p) (40 μM, 24 h) shows no cytotoxicity in PC12 cells and RAW cells, the viability of PC12 cells under t-BHP injury could reach more than 90%, demonstrating a strong protective effect[1].
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) can effectively reduce ROS levels in PC12 cells, and shows a decrease in malondialdehyde (MDA) levels and an increase in superoxide dismutase (SOD) activity[1].
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) increases the expression of NRF2 and HO-1 proteins in a concentration-dependent manner in PC12 cells, indicating that it protects against oxidative damage by activating the NRF2 pathway
Nrf2 activator 19 (10 μM, 3 h) reduces KEAP1 expression in PC12 cells, indicating a direct interaction with KEAP1[1].
Nrf2 activator 19 (1 μM, 1 h) shows moderate metabolic stability in rat liver microsomes[1].
Nrf2 activator 19 (10 μM, 24 h) shows a permeability of 7.64% in the Transwell-based blood-brain barrier (BBB) model (bEnd.3 cells), indicating its ability to cross the BBB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:t-BHP (200 μM) treated PC12 cells
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Concentration:2.5 μM-20 μM
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Incubation Time:24 h
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Result:Demonstrated that it plays a protective role against oxidative damage by activating the NRF2 pathway, which not only reduced the levels of MDA and ROS, but also increased the expression of SOD and the antioxidant activity is as high as 95% at a concentration of 10 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MCAO rat model[1]
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Dosage:5-20 mg/kg
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Administration:i.v. , 7 consecutive days
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Result:Reduced the infarct area of rats, indicating that it has a protective effect on the nerve damage caused by cerebral ischemia-reperfusion.
Enhanced the expression of NRF2 and HO-1 proteins in the nucleus of rat cerebral ischemia-reperfusion injury (MCAO) model in a concentration-dependent manner, and counteract ischemia-reperfusion injury by activating the NRF2 pathway.
In the Barnes maze experiment, rats were able to find the target box quickly, indicating that it can effectively restore the nerve function of rats.
Chemical Information
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Molecular Weight 400.42
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Formula C25H20O5
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SMILES
OC1=CC=C(C(/C=C/C2=C3C(OC(C4=CC=C(C)C=C4)=C3)=C(OC)C=C2)=O)C=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nrf2 activator 19 Related Classifications
HY-173307 Related Classifications
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