ADNP Antibody (YA6458)
(Synonyms: Activity dependent neuroprotective protein antibody; Activity dependent neuroprotector antibody; Activity-dependent neuroprotective protein antibody; Activity-dependent neuroprotector homeobox protein antibody; Adnp antibody; ADNP_HUMAN antibody; KIAA0784 antibody; ADNP1)ADNP Antibody (YA6458) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADNP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:1000 | 1:200-1:1000 | 1:100 | 1:200-1:1000 | 1:1000 |
Product Details
ADNP Antibody (YA6458) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADNP.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 150/100/75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 124 kDa
Recombinant protein within human ADNP aa 803-1,102.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ADNP may be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation
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Subcellular Localization
Nucleus,Chromosome
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Expression
Tissue_Specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues -
Subunit
Interacts (via N-terminal region) with beta-catenin/CTNNB1 (via the central armadillo domains); interaction is direct and stabilizes CTNNB1 by modulating its phosphorylation by glycogen synthase kinase-3 beta GSK3B
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SwissProt ID
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Synonyms
Activity dependent neuroprotective protein antibody; Activity dependent neuroprotector antibody; Activity-dependent neuroprotective protein antibody; Activity-dependent neuroprotector homeobox protein antibody; Adnp antibody; ADNP_HUMAN antibody; KIAA0784 antibody; ADNP1
Documentation
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