Curculigoside C
Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively.
For research use only. We do not sell to patients.
- CAS No.: 851713-74-1
- Formula: C22H26O12
- Molecular Weight:482.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Curculigoside C displays neuroprotective effect in the evaluation of salvaging SY5Y cell death induced by H2O2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Pharmacokinetic parameters of CC in rat plasma after intragastric administration[1].
| Dose (mg/kg) | t1/2 (h) | AUC0-60 (μg/L/h) | AUC0-∞ (μg/L/h) | F (%) | Vd (L/kg) | CLz (L/h/kg) | |
| 15 | 2.022 ± 0.184 | 0.106 ± 0.149 | 62.731 ± 10.149 | 66.310 ± 10.563 | 2.01 | 673.157 ± 116.509 | 231.036 ± 36.69 |
| 30 | 2.061 ± 0.325 | 0.111 ± 0.043 | 133.17 ± 48.434 | 140.656 ± 48.335 | 2.13 | 722.605 ± 316.306 | 234.188 ± 74.864 |
| 60 | 2.048 ± 0.227 | 0.111 ± 0.043 | 299.155 ± 80.954 | 316.980 ± 91.704 | 2.39 | 585.344 ± 124.289 | 201.905 ± 55.193 |
| 2.0 (i.v) | 1.153 ± 0.203 | - | 416.700 ± 70.401 | 420.700 ± 70.690 | - | 8.122 ± 1.973 | 4.869 ± 0.834 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 851713-74-1
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Molecular Weight 482.43
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Formula C22H26O12
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SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC(C=CC(O)=C2)=C2COC(C3=C(C(O)=CC=C3OC)OC)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Wu Q, et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1065-7. [Content Brief]
[2]. Di Wu, et al. Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS. Molecules. 2018 Dec 21;24(1):21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Curculigoside C Related Classifications
HY-N9095 Related Classifications
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