Multitarget AD-IN-3 

Multitarget AD-IN-3 is a brain-penetrant neuroprotective agent. Multitarget AD-IN-3 can selectively inhibit MAO-B with an IC₅₀ of 4.42 μM and a SI of 18.12. Multitarget AD-IN-3 can eliminate ROS. Multitarget AD-IN-3 Multitarget AD-IN-3 can inhibit Aβ_1-42 self-aggregation and can reverse Aβ_1-42-induced mitochondrial membrane depolarization and inhibit apoptosis. Multitarget AD-IN-3 can be used for the research of neurological disease, such as Alzheimer’s disease^[1].

Multitarget AD-IN-3 (10 μM) significantly inhibits the production of NO, TNF-α, and IL-6 in LPS-stimulated RAW 264.7 and BV-2 cells and downregulates the expression of COX-2 and NF-κB^[1].
Multitarget AD-IN-3 (10 μM) significantly reduces intracellular ROS accumulation induced by TBHP in SH-SY5Y cells^[1].
Multitarget AD-IN-3 can chelate Al³⁺, Cu²⁺, Fe²⁺, and Zn^2+[1].
Multitarget AD-IN-3 (25-50 μM, 24 h) dose-dependently inhibits Aβ_1-42 self-aggregation^[1].
Multitarget AD-IN-3 (10 μM, 18-24 h) can reverse Aβ_1-42-induced mitochondrial membrane depolarization, inhibit apoptosis and enhance the viability in SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

407.38

C₁₉H₁₇N₇O₄

O=C(N/N=C/C1=CC=CN1)C(N=NN2C(C=C3)=CC=C3NC(/C=C/C(O)=O)=O)=C2C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sobha A, et al. Multi-Target-Directed Triazole Derivatives: Design, Synthesis, and Evaluation of Synergistic Modulation in Alzheimer's Disease. ACS Chem Neurosci. 2025 Oct 1;16(19):3873-3885.  [Content Brief]