HDAC6-IN-77 

HDAC6-IN-77 is a highly selective HDAC6 inhibitor with an IC₅₀ of 7.0 nM.HDAC6-IN-77 induces neurite outgrowth.HDAC6-IN-77 exerts neuroprotective activity.HDAC6-IN-77 shows no significant toxicity on dopaminergic cells.HDAC6-IN-77 can be used for the research of Alzheimer's disease^[1].

HDAC6-IN-77 (compound 8g) potently and selectively inhibits purified HDAC6 with an IC₅₀ of 7.0 nM, and exhibits negligible activity against HDAC1, HDAC2, HDAC3, HDAC5 and HDAC8^[1].
HDAC6-IN-77 (1-9 μM; 6 h) selectively increases the level of acetylated α-tubulin (a marker of HDAC6 inhibition) in a dose-dependent manner in PC-12 cells in vitro, without affecting the level of acetylated histone H3 (a marker of class I HDAC inhibition)^[1].
HDAC6-IN-77 (20 μM) shows no significant cytotoxicity in PC-12 cells^[1].
HDAC6-IN-77 (0.5-2 μM; 48 h) promotes axonal growth in PC-12 cells, with an axonal growth rate of 80.2%, and exhibits a dose-dependent effect within the concentration range of 0.5, 1 and 2 μM^[1].
HDAC6-IN-77 (10 μM; 24 h) exerts neuroprotective activity against H₂O₂-induced oxidative damage in PC-12 cells^[1].
HDAC6-IN-77 (10 μM; 24 h) exerts neuroprotective activity against 6-OHDA-induced oxidative damage in PC-12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

334.77

C₁₇H₁₆ClFN₂O₂

ClC1=CC=C(CCN(CC2=CC=C(C(NO)=O)C=C2F)C3)C3=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu S, et al. Discovery of tetrahydroisoquinoline derivatives as selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting activities and neuroprotective activities. Bioorg Med Chem Lett. Published online February 17, 2026.  [Content Brief]