HDAC6-IN-77

HDAC6-IN-77 (compound 8g) potently and selectively inhibits purified HDAC6 with an IC₅₀ of 7.0 nM, and exhibits negligible activity against HDAC1, HDAC2, HDAC3, HDAC5 and HDAC8^[1].
HDAC6-IN-77 (1-9 μM; 6 h) selectively increases the level of acetylated α-tubulin (a marker of HDAC6 inhibition) in a dose-dependent manner in PC-12 cells in vitro, without affecting the level of acetylated histone H3 (a marker of class I HDAC inhibition)^[1].
HDAC6-IN-77 (20 μM) shows no significant cytotoxicity in PC-12 cells^[1].
HDAC6-IN-77 (0.5-2 μM; 48 h) promotes axonal growth in PC-12 cells, with an axonal growth rate of 80.2%, and exhibits a dose-dependent effect within the concentration range of 0.5, 1 and 2 μM^[1].
HDAC6-IN-77 (10 μM; 24 h) exerts neuroprotective activity against H₂O₂-induced oxidative damage in PC-12 cells^[1].
HDAC6-IN-77 (10 μM; 24 h) exerts neuroprotective activity against 6-OHDA-induced oxidative damage in PC-12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.