BN-82451 dihydrochloride
BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis.
For research use only. We do not sell to patients.
- CAS No.: 663172-95-0
- Formula: C18H28Cl2N2OS
- Molecular Weight:391.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
BN82451 exhibits IC50 values of 0.08 and 0.05 µM for COX-1 and COX-2, respectively[2].
BN82451 acts via three major pathways involved in neuronal death: excitotoxicity, oxidative stress, and inflammation, and is also a mitochondrial protective agent[2].
BN82451 inhibits lipid peroxidation in rat brain microsomes in a concentration-dependent manner with an IC50 value of 0.54 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 663172-95-0
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Molecular Weight 391.40
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Formula C18H28Cl2N2OS
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SMILES
OC1=C(C(C)(C)C)C=C(C2=CSC(CN)=N2)C=C1C(C)(C)C.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Anthony J Hannan, et al. Novel therapeutic targets for Huntington's disease. Expert Opin Ther Targets. 2005 Aug;9(4):639-50. [Content Brief]
[2]. Pierre Etienne Chabrier, et al. Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent. CNS Drug Rev. 2007 Fall;13(3):317-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BN-82451 dihydrochloride Related Classifications
HY-119274 Related Classifications
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