663172-95-0
Chemical Structure
BN-82451 dihydrochloride
- CAS No.: 663172-95-0
- Formula:C18H28Cl2N2OS
- Molecular Weight:391.40
IUPAC Name: 4-(2-(aminomethyl)thiazol-4-yl)-2,6-di-tert-butylphenol dihydrochloride
InChIKey: POTWDNZJOKKEMK-UHFFFAOYSA-N
SMILES: OC1=C(C(C)(C)C)C=C(C2=CSC(CN)=N2)C=C1C(C)(C)C.Cl.Cl
Biological Activity: BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis[1][2].
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BN-82451 dihydrochloride | BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis. | |||||||||||||||||||||
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- [1]. Anthony J Hannan, et al. Novel therapeutic targets for Huntington's disease. Expert Opin Ther Targets. 2005 Aug;9(4):639-50. [Content Brief]
- [2]. Pierre Etienne Chabrier, et al. Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent. CNS Drug Rev. 2007 Fall;13(3):317-32. [Content Brief]
Keywords
