2. Metabolic Enzyme/Protease TGF-beta/Smad Stem Cell/Wnt
  3. Phosphodiesterase (PDE) PKA
  4. PDE2-IN-1

PDE2-IN-1 is a potent and orally active PDE2 inhibitor with an IC50 of 0.6 μM, demonstrating neuroprotective effects. PDE2-IN-1 modulates the PKA/CREB/BDNF signaling pathway by inhibiting PDE2. PDE2-IN-1 improves memory deficits and cognitive impairment in an okadai acid (OKA)-induced Alzheimer’s disease (AD) mouse model. PDE2-IN-1 can be used for the research of AD.

For research use only. We do not sell to patients.

PDE2-IN-1

PDE2-IN-1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PDE2-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All PKA Isoform Specific Products:

View All Isoforms
PKA PKAR PKACα

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PDE2-IN-1 is a potent and orally active PDE2 inhibitor with an IC50 of 0.6 μM, demonstrating neuroprotective effects. PDE2-IN-1 modulates the PKA/CREB/BDNF signaling pathway by inhibiting PDE2. PDE2-IN-1 improves memory deficits and cognitive impairment in an okadai acid (OKA)-induced Alzheimer’s disease (AD) mouse model. PDE2-IN-1 can be used for the research of AD[1].

IC50 & Target[1]

PDE2

0.6 μM (IC50)

In Vitro

PDE2-IN-1 (compound 14c) (0-50 μM; 24 h) shows no cytotoxicity in neuronal cells (U251, SY5Y, and HMC3 cells)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE2-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: U251, SY5Y, and HMC3 cell lines
Concentration: 0, 1.5625, 3.125, 6.25, 12.5, 25, 50 μM
Incubation Time: 24 h
Result: Showed no effects on U251, SY5Y, and HMC3 cell survival rates.
Parmacokinetics
Species Dose Route AUC0-t AUC0-∞ MRT0-t MRT0-∞ T1/2 Tmax Vz-F_obs CL/F Cmax F
Rat[1] 2 mg/kg i.v. 3540.2 μg/L·h 3560.228 μg/L·h 4.292 h 4.481 h 4.437 h 0.083 h 3.493 L/kg 0.584 L/h/kg 1519.1 μg/L /
Rat[1] 20 mg/kg p.o. 34006.498 μg/L·h 34057.752 μg/L·h 7.856 h 7.916 h 4.418 h 2.167 h 3.748 L/kg 0.598 L/h/kg 3547.8 μg/L 95.66 %
In Vivo

PDE2-IN-1 (10 and 30 mg/kg, i.p., daily for 14 dyas) improves memory deficits and cognitive impairment in an OKA-induced AD mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (20-30 g) bilateral intracerebroventricularly injected with OKA[1]
Dosage: 10 and 30 mg/kg
Administration: i.p., daily for 14 days
Result: Had a negligible effect on the mean daily bodyweight profile in OKA-induced AD mice.
Showed no obvious changes of the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), carbamide (UREA), creatinine (CREA) and AST/ALT ratio in OKA-induced AD group and different doses group.
Led to minimal injury to hippocampal neurons.
Showed beneficial effects to ameliorate the memory and cognitive impairment in OKA-induced AD mice.
Ameliorated OKA-induced memory and cognitive impairment via PKA/CREB/BDNF pathway.
Alleviated synaptic impairments in OKA-induced AD mice.
Molecular Weight

396.36

Formula

C18H19F3N4O3
SMILES

O=C1C2=NN(CCO)C(C(NC(C3=CC=C(C(F)(F)F)C=C3)C)=O)=C2CCN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PDE2-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE2-IN-1Phosphodiesterase (PDE)PKAProtein kinase A2456-Tetrahydro-7H-pyrazolo[34-c]pyridine-7-onePDE2 inhibitorsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PDE2-IN-1
Cat. No.:
HY-179337
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.