hAChE-IN-1
hAChE-IN-1 (Compound 24) is a potent hAChE inhibitor with an IC50 of 1.09 μM. hAChE-IN-1 inhibits tau-oligomerization with an EC50 of 2.71 μM in cellular tau FRET assay.
For research use only. We do not sell to patients.
- Formula: C22H24N4O
- Molecular Weight:360.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hAChE 1.09 μM (IC50) |
tau-oligomerization 2.71 μM (EC50) |
hAChE-IN-1 (Compound 24; 1-10 μM; 24 h) is neuroprotective in SH-SY5Y cells transfected with WT tau[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells transfected with WT tau
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Concentration:1, 5 and 10 μM
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Incubation Time:24 h
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Result:Improved the cell viability in a concentration-dependent manner.
Chemical Information
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Molecular Weight 360.45
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Formula C22H24N4O
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SMILES
OC(C=CC=C1)=C1C(N2CCN(CC2)C3=NC=CN=C3)C4=CC=C(C)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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