hAChE-IN-1
hAChE-IN-1 (Compound 24) is a potent hAChE inhibitor with an IC50 of 1.09 μM. hAChE-IN-1 inhibits tau-oligomerization with an EC50 of 2.71 μM in cellular tau FRET assay.
For research use only. We do not sell to patients.
- Formula: C22H24N4O
- Molecular Weight:360.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
hAChE 1.09 μM (IC50) |
tau-oligomerization 2.71 μM (EC50) |
In Vitro
hAChE-IN-1 (Compound 24; 1-10 μM; 24 h) is neuroprotective in SH-SY5Y cells transfected with WT tau[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:SH-SY5Y cells transfected with WT tau
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Concentration:1, 5 and 10 μM
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Incubation Time:24 h
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Result:Improved the cell viability in a concentration-dependent manner.
Chemical Information
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Molecular Weight 360.45
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Formula C22H24N4O
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SMILES
OC(C=CC=C1)=C1C(N2CCN(CC2)C3=NC=CN=C3)C4=CC=C(C)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hAChE-IN-1 Related Classifications
HY-149233 Related Classifications
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