1. Membrane Transporter/Ion Channel
  2. Na+/Ca2+ Exchanger
  3. YM-244769 dihydrochloride

YM-244769 dihydrochloride 

Cat. No.: HY-136182
Handling Instructions

YM-244769 dihydrochloride is a potent Na+/Ca2+ exchange (NCX) inhibitor that preferentially inhibits NCX3 (IC50=18 nM). Neuronal and renal protection.

For research use only. We do not sell to patients.

YM-244769 dihydrochloride Chemical Structure

YM-244769 dihydrochloride Chemical Structure

CAS No. : 1780390-65-9

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Description

YM-244769 dihydrochloride is a potent Na+/Ca2+ exchange (NCX) inhibitor that preferentially inhibits NCX3 (IC50=18 nM). Neuronal and renal protection[1].

In Vitro

YM-244769 preferentially inhibits intracellular Na+-dependent 45Ca2+ uptake via NCX3 (IC50=18 nM); the inhibition is 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2, but it does not significantly affect extracellular Na+-dependent 45Ca2+ efflux via NCX isoforms[1].
YM-244769 (0.003-1 μM) inhibits dose dependently the initial rates of 45Ca2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC50 values of 68±2.9, 96±3.5, and 18±1.0 nM, respectively, indicating that YM-244769 is approximately four to five times more selective to NCX3 than other isoforms[1].
YM-244769 (0.3 or 1 μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e., SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e., SH-SY5Y cells primarily expressing NCX1)[1].

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells treated with NCX1 or NCX3 antisense
Concentration: 0.3 and 1 μM
Incubation Time:
Result: Hypoxia/reoxygenation-induced LDH release was significantly attenuated: reduction in cell damage was greater in cells treated with NCX3 antisense (by 61%) than in cells treated with NCX1 antisense (by 35%).
0.3 or 1 μM efficiently suppressed the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense more than in those treated with NCX3 antisense.
Molecular Weight

516.39

Formula

C₂₆H₂₄Cl₂FN₃O₃

CAS No.

1780390-65-9

SMILES

O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4.Cl.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

YM-244769YM244769YM 244769Na+/Ca2+ ExchangerNCX3NeuronalrenalprotectionInhibitorinhibitorinhibit

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YM-244769 dihydrochloride
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HY-136182
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