2. PI3K/Akt/mTOR
  3. PTEN
  4. BpV(HOpic)

BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.

For research use only. We do not sell to patients.

BpV(HOpic) Chemical Structure

BpV(HOpic) Chemical Structure

CAS No. : 722494-26-0

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10 mg USD 432 In-stock
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Based on 2 publication(s) in Google Scholar

BpV(HOpic) Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2].

IC50 & Target

IC50: 14 nM (PTEN)[1]
In Vitro

BpV(HOpic) (1 µM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment[3].
Bpv(HOpic) (1 µM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways[4].
BpV(HOpic) (1 µM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans[5].
Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BpV(HOpic) Related Antibodies
In Vivo

BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo[6].
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats are subjected to partial hepatic ischemia[6]
Dosage: 0.05 mg/kg
Administration: I.p. injections at the start of reperfusion
Result: Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.
Animal Model: Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia[7]
Dosage: 200 μg/kg
Administration: I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr
Result: Raised the level of serum creatinine and blood serum urea nitrogen.
Molecular Weight

347.24

Formula

C6H4K2NO8V
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=[V+3]12([O-]3)([O-][O-]1)([O-][O-]2)[N]4=CC(O)=CC=C4C3=O.[2 K+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (143.99 mM; ultrasonic and warming and heat to 60°C)

DMSO : 2.89 mg/mL (8.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8799 mL 14.3993 mL 28.7985 mL
5 mM 0.5760 mL 2.8799 mL 5.7597 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.8799 mL 14.3993 mL 28.7985 mL 71.9963 mL
5 mM 0.5760 mL 2.8799 mL 5.7597 mL 14.3993 mL
H2O 10 mM 0.2880 mL 1.4399 mL 2.8799 mL 7.1996 mL
15 mM 0.1920 mL 0.9600 mL 1.9199 mL 4.7998 mL
20 mM 0.1440 mL 0.7200 mL 1.4399 mL 3.5998 mL
25 mM 0.1152 mL 0.5760 mL 1.1519 mL 2.8799 mL
30 mM 0.0960 mL 0.4800 mL 0.9600 mL 2.3999 mL
40 mM 0.0720 mL 0.3600 mL 0.7200 mL 1.7999 mL
50 mM 0.0576 mL 0.2880 mL 0.5760 mL 1.4399 mL
60 mM 0.0480 mL 0.2400 mL 0.4800 mL 1.1999 mL
80 mM 0.0360 mL 0.1800 mL 0.3600 mL 0.9000 mL
100 mM 0.0288 mL 0.1440 mL 0.2880 mL 0.7200 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BpV(HOpic) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BpV(HOpic)722494-26-0PTENPhosphatase and tensin homologMMAC1PI3K/AKTMAPK/ERKsignallingInhibitorinhibitorinhibit

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