NS 1231 

NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke^[1].

NS 1231 (1-10 μM) increases the viability of NGF-differentiated PC12 cells and preserves the neurites of surviving cells when administered for 4 days after trophic factor (serum and NGF) withdrawal^[1].
NS 1231 (1-3 μM, 48 h) in combination with NGF significantly stimulates neurite outgrowth in undifferentiated PC12 cells^[1].
NS 1231 (1-3 μM, 5 mins) in combination with NGF enhances NGF-induced TrkA phosphorylation at the Shc-binding site (Tyr490) and ERK activation (Thr202/Tyr204) in undifferentiated PC12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NS 1231 (15 mg/kg, i.p., 2 mins after MCAO) reduces the total infarct volume in mice with middle cerebral artery occlusion (MCAO)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

326.78

C₁₈H₁₅ClN₂O₂

309711-72-6

O=C1NC2=C(C=C(C3=CC=C(Cl)C=C3)C4=C2CCCC4)/C1=N/O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dagø L, et al. NS 1231, a novel compound with neurotrophic-like effects in vitro and in vivo. J Neurochem. 2002 Apr;81(1):17-24.  [Content Brief]