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OY-201 is a potential and BBB-penetrated anti-ischemic stroke agent. OY-201 shows the good safety and neuroprotective activity in both in vitro and in vivo models.

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OY-201 Chemical Structure

OY-201 Chemical Structure

CAS No. : 2962943-05-9

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Description

OY-201 is a potential and BBB-penetrated anti-ischemic stroke agent. OY-201 shows the good safety and neuroprotective activity in both in vitro and in vivo models[1].

In Vivo

OY-201 (10-20 mg/kg, IP) attenuates brain injury of MCAO mice, and shows superior safety compared with sertraline[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (Middle cerebral artery occlusion (MACO)-induced brain infarction model)[1]
Dosage: 10 mg/kg and 20 mg/kg
Administration: IP
Result: Attenuated brain injury of MCAO mice. 10 mg/kg of compound OY-201 reduced the infarcted volume to 13.3% and decreased the neurological severity scores to 1.5. Moreover, treatment with a higher dose of compound OY-201 (20 mg/kg) did not further improve the results, which showed an almost equivalent protective effect. OY-201 at 20 mg/kg significantly ameliorated the mortality of MCAO mice (35.7%) and the survival rate of compound OY-201 was 100% at the dose of 10 mg/kg.
Molecular Weight

418.44

Formula

C25H33Cl2N
CAS No.
SMILES

CCCCCCCCN([C@H]1CC[C@H](C2=CC=CC=C21)C3=CC=C(C(Cl)=C3)Cl)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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OY-201 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OY-2012962943-05-9OY201OY 201OthersIschemic strokeNeuroprotectionSSRIsSertralineSertraline analoguesblood-brain barrierInhibitorinhibitorinhibit

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