4A7C-301
Based on 1 publication(s) in Google Scholar
4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease.
For research use only. We do not sell to patients.
- Purity: 99.86%
- Formula: C27H38ClN9
- Molecular Weight:524.10
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Neuroprotective Compound Library
HY-L070
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Nuclear Receptor Compound Library
HY-L126
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) 4A7C-301
MoreAll Nuclear Hormone Receptor 4A/NR4A Isoforms
More
Biological Activity
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Nurr1/NR4A2 |
Chemical Information
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Appearance Solid
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Molecular Weight 524.10
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Formula C27H38ClN9
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Color White to light yellow
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SMILES
ClC1=CC=C2C(NCCNC3=NC(N4CCN(CC)CC4)=CC(N5CCN(CC)CC5)=N3)=CC=NC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
Comparative Profiling and Chemogenomics Application of Chemical Tools for NR4A Nuclear Receptors. [Abstract]2025 Oct 9;68(19):19955-19970. PMID: 40968635
Solvent & Solubility
DMSO : 140 mg/mL (267.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9080 mL | 9.5402 mL | 19.0803 mL | 47.7008 mL |
| 5 mM | 0.3816 mL | 1.9080 mL | 3.8161 mL | 9.5402 mL | |
| 10 mM | 0.1908 mL | 0.9540 mL | 1.9080 mL | 4.7701 mL | |
| 15 mM | 0.1272 mL | 0.6360 mL | 1.2720 mL | 3.1801 mL | |
| 20 mM | 0.0954 mL | 0.4770 mL | 0.9540 mL | 2.3850 mL | |
| 25 mM | 0.0763 mL | 0.3816 mL | 0.7632 mL | 1.9080 mL | |
| 30 mM | 0.0636 mL | 0.3180 mL | 0.6360 mL | 1.5900 mL | |
| 40 mM | 0.0477 mL | 0.2385 mL | 0.4770 mL | 1.1925 mL | |
| 50 mM | 0.0382 mL | 0.1908 mL | 0.3816 mL | 0.9540 mL | |
| 60 mM | 0.0318 mL | 0.1590 mL | 0.3180 mL | 0.7950 mL | |
| 80 mM | 0.0239 mL | 0.1193 mL | 0.2385 mL | 0.5963 mL | |
| 100 mM | 0.0191 mL | 0.0954 mL | 0.1908 mL | 0.4770 mL |
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