2. NBQX disodium

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.

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NBQX disodium Chemical Structure

NBQX disodium Chemical Structure

CAS No. : 479347-86-9

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NBQX disodium Related Antibodies

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Description

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].

IC50 & Target

AMPA receptor[1]
In Vitro

NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NBQX disodium Related Antibodies
In Vivo

NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2].
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2]
Dosage: 20 mg/kg
Administration: IP; for 3 days
Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
Molecular Weight

380.24

Formula

C12H6N4Na2O6S
CAS No.
SMILES

O=C([N-]1)C([N-]C2=C1C3=C(C([N+]([O-])=O)=C2)C(S(N)(=O)=O)=CC=C3)=O.[Na+].[Na+]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBQX disodium479347-86-9FG9202 disodiumInhibitorinhibitorinhibit

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