1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. NBQX disodium

NBQX disodium (Synonyms: FG9202 disodium)

Cat. No.: HY-15068A
Handling Instructions

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.

For research use only. We do not sell to patients.

NBQX disodium Chemical Structure

NBQX disodium Chemical Structure

CAS No. : 479347-86-9

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Description

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].

IC50 & Target

AMPA receptor[1]

In Vitro

NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2].
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2]
Dosage: 20 mg/kg
Administration: IP; for 3 days
Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
Molecular Weight

380.24

Formula

C₁₂H₆N₄Na₂O₆S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NBQX disodium
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