NBQX disodium
Based on 23 publication(s) in Google Scholar
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.
For research use only. We do not sell to patients.
- Purity: 98.96%
- CAS No.: 479347-86-9
- Formula: C12H6N4Na2O6S
- Molecular Weight:380.24
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Membrane Transporter/Ion Channel Compound Library
HY-L011
-
Neuronal Signaling Compound Library
HY-L013
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Anti-Alzheimer's Disease Compound Library
HY-L069
-
Neuroprotective Compound Library
HY-L070
-
Anti-Parkinson's Disease Compound Library
HY-L085
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
Antidepressant Compound Library
HY-L108
-
Human Metabolite Library
HY-L123
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Ion Channel Compound Library
HY-L166
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
Publications Citing Use of MedChemExpress (MCE) NBQX disodium
More- Nat Med. 2019 Feb;25(2):337-349. [Abstract]
- Nature. 2026 Jan;649(8096):423-431. [Abstract]
- Nature. 2024 Jul;631(8022):826-834. [Abstract]
- Nat Neurosci. 2025 Jul;28(7):1404-1417. [Abstract]
- Nat Commun. 2026 Apr 3;17(1):3462.
- Neuron. 2026 Mar 26:S0896-6273(26)00120-0. [Abstract]
- Neuron. 2025 Aug 27:S0896-6273(25)00591-4. [Abstract]
- Theranostics. 2023 May 11;13(9):2946-2961. [Abstract]
- Phytomedicine. 2025 Apr:139:156457. [Abstract]
- Neurosci Bull. 2026 Feb 2. [Abstract]
- CNS Neurosci Ther. 2024 Mar;30(3):e14675. [Abstract]
- Int Immunopharmacol. 2024 May 30:133:112080. [Abstract]
- Neuropharmacology. 2026 Nov 1:298:111043.
- J Neurochem. 2022 Nov;163(4):310-326. [Abstract]
- Sci Rep. 2024 Mar 12;14(1):6011. [Abstract]
- Brain Res Bull. 2025 May 5:111371. [Abstract]
- Neural Plast. 2021 Jul 8:2021:7806370. [Abstract]
- Heliyon. 2024 Sep 3;10(17):e37358. [Abstract]
- Behav Pharmacol. 2025 Apr 1;36(2-3):127-136. [Abstract]
- bioRxiv. 2026 Jun 5:2026.06.04.730242. [Abstract]
- bioRxiv. 2025 Nov 13.
- bioRxiv. 2024 November 03.
- Oxid Med Cell Longev. 2022 Apr 15;2022:3716609. [Abstract]
Customer Validation & Images
-
Histological Imaging/Staining
-
Cell Imaging/Staining
-
IF
-
Flow Cytometry
-
ELISA
All iGluR Isoforms
More
Biological Activity
AMPA receptor[1]
NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2]
-
Dosage:20 mg/kg
-
Administration:IP; for 3 days
-
Result:Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
Chemical Information
-
CAS No. 479347-86-9
-
Appearance Solid
-
Molecular Weight 380.24
-
Formula C12H6N4Na2O6S
-
Color Brown to dark brown
-
SMILES
O=C([N-]1)C([N-]C2=C1C3=C(C([N+]([O-])=O)=C2)C(S(N)(=O)=O)=CC=C3)=O.[Na+].[Na+]
-
Synonyms
FG9202 disodium
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (23)
-
Journal Impact Factor
-
Most Recent
-
Nat Med
Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior. [Abstract]2019 Feb;25(2):337-349. PMID: 30643290 -
Nature
2026 Jan;649(8096):423-431. PMID: 41193806 -
Nature
2024 Jul;631(8022):826-834. PMID: 38987597
NBQX disodium purchased from MedChemExpress. Usage Cited in: Nature. 2024 Jul;631(8022):826-834. [Abstract]
Representative images showing the calcein-PI staining of cultured neurons from Asic1a+/+ and Asic1a-/- mice with different treatments. GluR-B: glutamate receptor blockers consisted of 50 μM D-AP5, 10 μM NBQX and 10 μM LY341495.
-
Nat Neurosci
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy. [Abstract]2025 Jul;28(7):1404-1417. PMID: 40425792 -
-
Neuron
Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits. [Abstract]2026 Mar 26:S0896-6273(26)00120-0. PMID: 41895265 -
Neuron
Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth. [Abstract]2025 Aug 27:S0896-6273(25)00591-4. PMID: 40897174 -
Theranostics
Chemogenetic activation of the HPC-mPFC pathway improves cognitive dysfunction in lipopolysaccharide -induced brain injury. [Abstract]2023 May 11;13(9):2946-2961. PMID: 37284451
NBQX disodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 May 11;13(9):2946-2961. [Abstract]
NBQX (10 nmol/mL, 1 µl /side, via microinjection into the mPFC) and D-AP5 effectively reduce the express of CaMKIIα, pCREB/CREB, BDNF, and TrkB in mPFC, while activation of HPC-mPFC prevents the decrease (* LPS+CNO versus LPS, # LPS+NBQX/D-AP5+CNO versus LPS+CNO). Data were presented as mean ± SEM. n=5/group. * p < 0.05, ** p < 0.01, # p<0.05, ## p<0.01.
-
Phytomedicine
L-theanine ameliorates traumatic-brain-injury-induced hippocampal neuronal death in rats. [Abstract]2025 Apr:139:156457. PMID: 40023064
NBQX disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr:139:156457. [Abstract]
Representative images of FJB-positive neurons, marking degenerating neurons in the CA1, CA3, and DG regions post-TBI. The results showed that, compared with the TBI‑vehicle group, the NBQX (30 mg/kg) treatment group exhibited a significant reduction in neuronal death in the CA1, CA3, and DG regions of the rat hippocampus.
-
Neurosci Bull
FOXG1 Hierarchically Shapes Synaptic Functions in Striatal iSPNs and Contributes to ASD Etiology. [Abstract]2026 Feb 2. PMID: 41627775 -
CNS Neurosci Ther
Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia. [Abstract]2024 Mar;30(3):e14675. PMID: 38488453 -
Int Immunopharmacol
AMPA receptor inhibition alleviates inflammatory response and myocardial apoptosis after myocardial infarction by inhibiting TLR4/NF-κB signaling pathway. [Abstract]2024 May 30:133:112080. PMID: 38613882
NBQX disodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080. [Abstract]
NBQX (1 mg/kg/d; i.p.; once daily for 4 weeks). UNEL showed that activation of AMPAR increased cardiomyocyte apoptosis in vitro, but incubation with a NF-κB-specific inhibitor BAY 11-7082 reversed this effect.
NBQX disodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080. [Abstract]
NBQX (NB, 1 mg/kg/d; i.p.; once daily for 4 weeks). Apoptosis measurement by flow cytometry shows that activation of AMPAR increased apoptosis, but this effect was reversed by BAY 11-7082.
NBQX disodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080. [Abstract]
NBQX (NB, 30 μM; added to the medium 6 h before hypoxia stimulation). ELISA method was employed to evaluate TNF-α, IL-1β, IL-6 and IL-10 levels in the culture medium of each group(n = 6). Inhibition of AMPA receptor decreased pro-inflammatory factor production and increased anti-inflammatory factor production. *:p < 0.05;**:p < 0.01;***:p < 0.005; ****:p < 0.001.
-
-
J Neurochem
Somatostatin interneurons inhibit excitatory transmission mediated by astrocytic GABAB and presynaptic GABAB and adenosine A1 receptors in the hippocampus. [Abstract]2022 Nov;163(4):310-326. PMID: 35775994 -
Sci Rep
Characterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array. [Abstract]2024 Mar 12;14(1):6011. PMID: 38472288 -
Brain Res Bull
Excitation-inhibition imbalance in the auditory cortex causes sound recognition impairment in noisy environment in hidden hearing loss mice. [Abstract]2025 May 5:111371. PMID: 40334993 -
Neural Plast
Astrocytes in the Ventromedial Hypothalamus Involve Chronic Stress-Induced Anxiety and Bone Loss in Mice. [Abstract]2021 Jul 8:2021:7806370. PMID: 34306063 -
Heliyon
NBQX mediates ventricular fibrillation susceptibility in rat models of anxiety via the Nrf2/HO-1 pathway. [Abstract]2024 Sep 3;10(17):e37358. PMID: 39296140 -
Behav Pharmacol
Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities. [Abstract]2025 Apr 1;36(2-3):127-136. PMID: 39611623 -
bioRxiv
iAstrocytes model cytokine influences on complement expression and neuronal network synchronization. [Abstract]2026 Jun 5:2026.06.04.730242. PMID: 42282708 -
-
-
Oxid Med Cell Longev
Activation of TGR5 Ameliorates Streptozotocin-Induced Cognitive Impairment by Modulating Apoptosis, Neurogenesis, and Neuronal Firing. [Abstract]2022 Apr 15;2022:3716609. PMID: 35464765
Solvent & Solubility
DMSO : 100 mg/mL (262.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (131.50 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (2.63 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (2.63 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
-
Data Sheet (281 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19(8):1174-84. [Content Brief]
[2]. Wen Chen, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016 Nov 23;11(11):e0166672. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.6299 mL | 13.1496 mL | 26.2992 mL | 65.7480 mL |
| 5 mM | 0.5260 mL | 2.6299 mL | 5.2598 mL | 13.1496 mL | |
| 10 mM | 0.2630 mL | 1.3150 mL | 2.6299 mL | 6.5748 mL | |
| 15 mM | 0.1753 mL | 0.8766 mL | 1.7533 mL | 4.3832 mL | |
| 20 mM | 0.1315 mL | 0.6575 mL | 1.3150 mL | 3.2874 mL | |
| 25 mM | 0.1052 mL | 0.5260 mL | 1.0520 mL | 2.6299 mL | |
| 30 mM | 0.0877 mL | 0.4383 mL | 0.8766 mL | 2.1916 mL | |
| 40 mM | 0.0657 mL | 0.3287 mL | 0.6575 mL | 1.6437 mL | |
| 50 mM | 0.0526 mL | 0.2630 mL | 0.5260 mL | 1.3150 mL | |
| 60 mM | 0.0438 mL | 0.2192 mL | 0.4383 mL | 1.0958 mL | |
| 80 mM | 0.0329 mL | 0.1644 mL | 0.3287 mL | 0.8218 mL | |
| 100 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6575 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NBQX disodium Related Classifications
HY-15068A Related Classifications
Powered by Bioz