1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

Bemesetron (Synonyms: MDL 72222)

Cat. No.: HY-B1541 Purity: >99.0%
Handling Instructions

Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effects.

For research use only. We do not sell to patients.

Bemesetron Chemical Structure

Bemesetron Chemical Structure

CAS No. : 40796-97-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM[1]. Neuroprotective effects[2].

IC50 & Target[1]

5-HT3 Receptor

0.33 nM (IC50)

In Vitro

Blockade of 5-HT3 receptor with Bemesetron (MDL7222) reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Bemesetron (0.01, 0.1 and 1 μM) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease of MTT reduction showing 74.9±2.4 and 79.0 ±2.5% with 1 μM and 5 μM, respectively, which are maximal effects[2].
Pretreatment with Bemesetron (1 μM), Y25130 (5 AM) or MK-801 (10 μM) significantly, but not completely, inhibits the H2O2-induced elevation of [Ca2+]c[2].
Bemesetron (1 μM) inhibit H2O2-induced elevation of glutamate release showing 0.55±0.10 μM[2].
Bemesetron (1 μM) inhibits H2O2-induced ROS generation[2].
Bemesetron (1 μM) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity[2].

In Vivo

Bemesetron is used in the doses of 0.1, 1 and 10 mg/kg i.p. The lowest dose do not cause any significant change in catalepsy. However, 1 mg/kg Bemesetron causes a significant reduction of catalepsy (from 90 min after haloperidol), while 10 mg/kg significantly potentiates the phenomenon (from 60 min after haloperidol). The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after haloperidol[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1826 mL 15.9129 mL 31.8258 mL
5 mM 0.6365 mL 3.1826 mL 6.3652 mL
10 mM 0.3183 mL 1.5913 mL 3.1826 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







O=C(O[[email protected]@H]1C[[email protected]@H](N2C)CC[[email protected]@H]2C1)C3=CC(Cl)=CC(Cl)=C3

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Cat. No.: HY-B1541