40796-97-2
40796-97-2
Chemical Structure
Bemesetron
Synonym(s): MDL 72222
- CAS No.: 40796-97-2
- Formula:C15H17Cl2NO2
- Molecular Weight:314.21
IUPAC Name: (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate
InChIKey: MNJNPLVXBISNSX-WDNDVIMCSA-N
SMILES: O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C3=CC(Cl)=CC(Cl)=C3
Biological Activity: Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM[1]. Neuroprotective effect[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bemesetron | 99.05% | Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect. | ||||||||||||||||||||
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References
- [1]. Peters JA, et al. An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol. 1993 Oct;110(2):665-76. [Content Brief]
- [2]. Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300. [Content Brief]
