40796-97-2
40796-97-2
Chemical Structure
Bemesetron
Synonym(s): MDL 72222
- CAS No.: 40796-97-2
- Formula:C15H17Cl2NO2
- Molecular Weight:314.21
IUPAC Name: (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate
InChIKey: MNJNPLVXBISNSX-WDNDVIMCSA-N
SMILES: O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C3=CC(Cl)=CC(Cl)=C3
Biological Activity: Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM[1]. Neuroprotective effect[2].
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Bemesetron | 99.05% | Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect. | ||||||||||||||||||||
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Tropanserin | 99.92% | Tropanserin is a serotoninergic active compound, as well as a 5HT3 receptor antagonist. Tropanserin modulates Cardio-respiratory reflex effects of an exogenous serotonin challenge. | ||||||||||||||||||||
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Tropacocaine hydrochloride | Tropacocaine hydrochloride is a tropane. | |||||||||||||||||||||
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3α-Benzoyloxytropane hydrochloride | 3α-Benzoyloxytropane hydrochloride is a tropane. | |||||||||||||||||||||
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Homatropine | 95.0% | Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent. | ||||||||||||||||||||
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Homatropine Bromide | 99.88% | Homatropine Bromide is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent. | ||||||||||||||||||||
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L-Hyoscyamine hydrobromide | L-Hyoscyamine (Hyoscyamine) hydrobromide is an anticholinergic agent that may potentially affect breastfeeding and milk production. L-Hyoscyamine hydrobromide is not likely to interfere with breastfeeding when used in single doses. L-Hyoscyamine hydrobromide should be monitored for signs of decreased lactation during long-term use. | |||||||||||||||||||||
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Phyllalbine | Phyllalbine is an alkaloid compound found in the roots of Convolvulus subhirsutus, exhibiting both central and peripheral sympathomimetic effects, making it a promising candidate for neurological disease research. | |||||||||||||||||||||
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Convolamine | 99.89% | Convolamine is a tropane alkaloid and a potent Sigma-1 receptor positive allosteric modulator with an IC50 value of 289 nM. Convolamine can be extracted from Convolvulus plauricalis. Convolamine exhibits cognitive-improving and neuroprotective properties. Convolamine can be used in research related to Wolfram syndrome and Alzheimer's disease. | ||||||||||||||||||||
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Convolamine hydrochloride | Convolamine hydrochloride is a tropane alkaloid and a potent Sigma-1 receptor positive allosteric modulator with an IC50 value of 289 nM. Convolamine hydrochloride can be extracted from Convolvulus plauricalis. Convolamine hydrochloride exhibits cognitive-improving and neuroprotective properties. Convolamine hydrochloride can be used in research related to Wolfram syndrome and Alzheimer's disease. | |||||||||||||||||||||
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Homatropine hydrochloride | Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs. | |||||||||||||||||||||
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References
- [1]. Peters JA, et al. An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol. 1993 Oct;110(2):665-76. [Content Brief]
- [2]. Lee HJ, et al. Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Life Sci. 2005 Dec 5;78(3):294-300. [Content Brief]
