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Cat. No.: HY-149820

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MAO-B-IN-22

MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC₅₀ of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect.

For research use only. We do not sell to patients.

CAS No.: 2902600-76-2
Formula: C₂₀H₁₈FNO₂
Molecular Weight:323.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MAO-B-IN-22 Chemical Structure

CAS No.: 2902600-76-2

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Sample (0.1mg)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

MAO-B-IN-22 (compound 6h) (2.5-50 μM, 24 h) can protect hydrogen peroxide-induced oxidative damage and improve cell viability in a dose-dependent manner^[1].
MAO-B-IN-22 (compound 6h) (0.5-10 μM, 24 h) can dose-dependently reduce LPS-induced NO production and has anti-neuroinflammatory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC-12 cells
Concentration:

2.5 μM, 10.0 μM, 50.0 μM
Incubation Time:

24 h
Result:

Increased cell viability to 59.8%, 69.6% and 77.2% of the control value at doses of 2.5 μM, 10.0 μM and 50.0 μM, respectively.

Western Blot Analysis^[1]

Cell Line:

BV-2 cells
Concentration:

0.5 μM, 2.5 μM, 10.0 μM
Incubation Time:

24 h
Result:

Significantly reduced LPS-induced NO production by 13.5%, 28.0% and 76.1% at concentrations of 0.5 μM, 2.5 μM and 10.0 μM, respectively.
Inhibited the release of ROS induced by lipopolysaccharide, and the inhibitory rates were 21.2% and 99.0% at the concentration of 2.5 μM and 10.0 μM , respectively.
Significantly inhibited the phosphorylation of IκBα to p-IκBα, and inhibited the translocation of p65 from the cytoplasm to the nucleus.

In Vivo

MAO-B-IN-22 (compound 6h)(53.5 mg/kg, oral gavage, once a day for 3 weeks) can attenuate the level of dopaminergic neurotransmitters and reduce the level of oxidative damage caused by ROS by inhibiting MAO-B Motor impairment in mice can alleviate motor impairment in MPTP-treated mice and may improve symptoms of PD in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6C mice^[1]
Dosage:

53.5 mg/kg
Administration:

oral gavage, once a day for 3 weeks
Result:

Significantly improved traction test scores and reduced BWT times, T-turns and T-totals.
Restored DA levels and reduce MDA levels.

Chemical Information

CAS No. 2902600-76-2
Molecular Weight 323.36
Formula C₂₀H₁₈FNO₂
SMILES

OC1=C(C=CC(OCC2=CC=C(C=C2)F)=C1)CNC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhongcheng Cao, et al. Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease. Eur J Med Chem. 2023 Mar 5;249:115142. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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