2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-22

MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect.

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MAO-B-IN-22 Chemical Structure

MAO-B-IN-22 Chemical Structure

CAS No. : 2902600-76-2

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MAO-B-IN-22 Related Antibodies

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Description

MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect[1].

In Vitro

MAO-B-IN-22 (compound 6h) (2.5-50 μM, 24 h) can protect hydrogen peroxide-induced oxidative damage and improve cell viability in a dose-dependent manner[1].
MAO-B-IN-22 (compound 6h) (0.5-10 μM, 24 h) can dose-dependently reduce LPS-induced NO production and has anti-neuroinflammatory activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-22 Related Antibodies

Cell Viability Assay[1]

Cell Line: PC-12 cells
Concentration: 2.5 μM, 10.0 μM, 50.0 μM
Incubation Time: 24 h
Result: Increased cell viability to 59.8%, 69.6% and 77.2% of the control value at doses of 2.5 μM, 10.0 μM and 50.0 μM, respectively.

Western Blot Analysis[1]

Cell Line: BV-2 cells
Concentration: 0.5 μM, 2.5 μM, 10.0 μM
Incubation Time: 24 h
Result: Significantly reduced LPS-induced NO production by 13.5%, 28.0% and 76.1% at concentrations of 0.5 μM, 2.5 μM and 10.0 μM, respectively.
Inhibited the release of ROS induced by lipopolysaccharide, and the inhibitory rates were 21.2% and 99.0% at the concentration of 2.5 μM and 10.0 μM , respectively.
Significantly inhibited the phosphorylation of IκBα to p-IκBα, and inhibited the translocation of p65 from the cytoplasm to the nucleus.
In Vivo

MAO-B-IN-22 (compound 6h)(53.5 mg/kg, oral gavage, once a day for 3 weeks) can attenuate the level of dopaminergic neurotransmitters and reduce the level of oxidative damage caused by ROS by inhibiting MAO-B Motor impairment in mice can alleviate motor impairment in MPTP-treated mice and may improve symptoms of PD in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6C mice[1]
Dosage: 53.5 mg/kg
Administration: oral gavage, once a day for 3 weeks
Result: Significantly improved traction test scores and reduced BWT times, T-turns and T-totals.
Restored DA levels and reduce MDA levels.
Molecular Weight

323.36

Formula

C20H18FNO2
CAS No.
SMILES

OC1=C(C=CC(OCC2=CC=C(C=C2)F)=C1)CNC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-222902600-76-2Monoamine OxidaseMAOantioxidantmetal chelating abilityBBBneuroprotectiveInhibitorinhibitorinhibit

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