Search Result

Targets Recommended:	Aromatase

Results for "All natural aromatase Inhibitors" in MCE Product Catalog:

By Targets:	Aromatase (10) 5-HT Receptor (2) AChE (1) ADC Cytotoxin (2) Adenosine Receptor (1) Adenylate Cyclase (1) Adiponectin Receptor (1) Adrenergic Receptor (2) Aminopeptidase (1) AMPK (3) Amyloid-β (1) Androgen Receptor (2) Antibiotic (20) Apoptosis (58) Aryl Hydrocarbon Receptor (3) ATM/ATR (1) Autophagy (53) Bacterial (40) Bcl-2 Family (8) Bcr-Abl (2) c-Kit (1) c-Met/HGFR (1) CaMK (1) Casein Kinase (3) Caspase (1) CDK (4) CMV (1) COX (6) CXCR (1) Cytochrome P450 (12) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (2) Drug-Linker Conjugates for ADC (1) DYRK (4) E1/E2/E3 Enzyme (2) E3 Ligase Ligand-Linker Conjugate (1) EGFR (4) Endogenous Metabolite (69) Ephrin Receptor (1) Epigenetic Reader Domain (4) ERK (1) Estrogen Receptor/ERR (4) FAAH (1) Factor Xa (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (6) Fungal (18) FXR (1) GABA Receptor (2) Glucosidase (2) GLUT (1) Glutathione Peroxidase (1) GSK-3 (1) HBV (2) HDAC (5) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (4) Histamine Receptor (1) Histone Acetyltransferase (4) Histone Demethylase (2) Histone Methyltransferase (2) HIV (5) HIV Integrase (1) HSP (3) iGluR (5) IKK (3) Influenza Virus (15) Insulin Receptor (1) Interleukin Related (4) JAK (2) JNK (3) Keap1-Nrf2 (3) Lipoxygenase (2) LXR (1) mAChR (1) MAP3K (1) MDM-2/p53 (1) mGluR (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mitophagy (8) MMP (3) Monoamine Oxidase (2) nAChR (3) Nampt (1) NF-κB (11) NO Synthase (3) NOD-like Receptor (NLR) (3) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (4) P-glycoprotein (2) p38 MAPK (3) Parasite (15) PDHK (1) PGE synthase (1) Phosphatase (3) Phosphodiesterase (PDE) (1) PI3K (3) Pim (1) PKA (1) PKC (4) Potassium Channel (7) PPAR (7) Prostaglandin Receptor (1) PROTAC (1) Proteasome (3) Proton Pump (1) RAR/RXR (3) Reactive Oxygen Species (22) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (1) RIP kinase (1) RSV (1) SARS-CoV (2) SGLT (1) Sirtuin (4) Smo (1) Sodium Channel (2) Src (2) STAT (5) TAM Receptor (1) TGF-beta/Smad (1) Thrombin (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) Topoisomerase (4) Trk Receptor (2) TRP Channel (5) Tyrosinase (4) VEGFR (2) Virus Protease (4) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (225) Cardiovascular Disease (26) Endocrinology (10) Infection (90) Inflammation/Immunology (128) Metabolic Disease (77) Neurological Disease (54)

By Targets:

Aromatase (10)

5-HT Receptor (2)

AChE (1)

ADC Cytotoxin (2)

Adenosine Receptor (1)

Adenylate Cyclase (1)

Adiponectin Receptor (1)

Adrenergic Receptor (2)

Aminopeptidase (1)

AMPK (3)

Amyloid-β (1)

Androgen Receptor (2)

Antibiotic (20)

Apoptosis (58)

Aryl Hydrocarbon Receptor (3)

ATM/ATR (1)

Autophagy (53)

Bacterial (40)

Bcl-2 Family (8)

Bcr-Abl (2)

c-Kit (1)

c-Met/HGFR (1)

CaMK (1)

Casein Kinase (3)

Caspase (1)

CDK (4)

CMV (1)

COX (6)

CXCR (1)

Cytochrome P450 (12)

Dipeptidyl Peptidase (1)

DNA/RNA Synthesis (2)

Drug-Linker Conjugates for ADC (1)

DYRK (4)

E1/E2/E3 Enzyme (2)

E3 Ligase Ligand-Linker Conjugate (1)

EGFR (4)

Endogenous Metabolite (69)

Ephrin Receptor (1)

Epigenetic Reader Domain (4)

ERK (1)

Estrogen Receptor/ERR (4)

FAAH (1)

Factor Xa (1)

Fatty Acid Synthase (FASN) (2)

Ferroptosis (6)

Fungal (18)

FXR (1)

GABA Receptor (2)

Glucosidase (2)

GLUT (1)

Glutathione Peroxidase (1)

GSK-3 (1)

HBV (2)

HDAC (5)

Hedgehog (1)

HIF/HIF Prolyl-Hydroxylase (4)

Histamine Receptor (1)

Histone Acetyltransferase (4)

Histone Demethylase (2)

Histone Methyltransferase (2)

HIV (5)

HIV Integrase (1)

HSP (3)

iGluR (5)

IKK (3)

Influenza Virus (15)

Insulin Receptor (1)

Interleukin Related (4)

JAK (2)

JNK (3)

Keap1-Nrf2 (3)

Lipoxygenase (2)

LXR (1)

mAChR (1)

MAP3K (1)

MDM-2/p53 (1)

mGluR (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

Mitophagy (8)

MMP (3)

Monoamine Oxidase (2)

nAChR (3)

Nampt (1)

NF-κB (11)

NO Synthase (3)

NOD-like Receptor (NLR) (3)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (4)

P-glycoprotein (2)

p38 MAPK (3)

Parasite (15)

PDHK (1)

PGE synthase (1)

Phosphatase (3)

Phosphodiesterase (PDE) (1)

PI3K (3)

Pim (1)

PKA (1)

PKC (4)

Potassium Channel (7)

PPAR (7)

Prostaglandin Receptor (1)

PROTAC (1)

Proteasome (3)

Proton Pump (1)

RAR/RXR (3)

Reactive Oxygen Species (22)

Reverse Transcriptase (2)

Ribosomal S6 Kinase (RSK) (1)

RIP kinase (1)

RSV (1)

SARS-CoV (2)

SGLT (1)

Sirtuin (4)

Smo (1)

Sodium Channel (2)

Src (2)

STAT (5)

TAM Receptor (1)

TGF-beta/Smad (1)

Thrombin (1)

TNF Receptor (3)

Toll-like Receptor (TLR) (1)

Topoisomerase (4)

Trk Receptor (2)

TRP Channel (5)

Tyrosinase (4)

VEGFR (2)

Virus Protease (4)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (225)

Cardiovascular Disease (26)

Endocrinology (10)

Infection (90)

Inflammation/Immunology (128)

Metabolic Disease (77)

Neurological Disease (54)

567

Inhibitors & Agonists

114

Screening Libraries

Dye Reagents

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

446

Natural
Products

Cat. No.	Product Name	Target	Research Areas

HY-D0987

Stains-All
Others Others

Stains-All is a cationic carbocyanine dye.

Stains-All	Others	Others
Stains-All is a cationic carbocyanine dye.

HY-W004500

All-trans-retinal	Endogenous Metabolite	Others
All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions, all-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal.

HY-N7495

all-trans-Anhydro Retinol Anhydrovitamin A	Endogenous Metabolite	Metabolic Disease
all-trans-Anhydro Retinol (Anhydrovitamin A) is a metabolite of Vitamin A. all-trans-Anhydro Retinol is used in synthetic multivitamin preparations.

HY-107494A

all-trans-4-Oxoretinoic acid All-trans 4-Keto Retinoic Acid	Endogenous Metabolite	Metabolic Disease
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-N0292

Oleuropein	PPAR Apoptosis Aromatase	Cancer Inflammation/Immunology Cardiovascular Disease
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits *aromatase*.

HY-N0716

Berberine natural Yellow 18	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Endogenous Metabolite Antibiotic	Inflammation/Immunology
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties.

HY-136063

Mefentrifluconazole	Fungal Cytochrome P450	Infection
Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (K_d= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC₅₀=0.92 μM).

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.
HY-N6609

Magnocurarine
Others Others

Magnocurarine a natural compound isolated from Tiliacora racemosa.
HY-14274

Anastrozole
ZD1033
Aromatase Cancer

Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC₅₀ of 15 nM.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

Magnocurarine	Others	Others
Magnocurarine a natural compound isolated from Tiliacora racemosa.

Anastrozole ZD1033	Aromatase	Cancer
Anastrozole is a potent, highly selective *aromatase* inhibitor, which inhibits human placental aromatase with an IC₅₀ of 15 nM.

HY-13632

Exemestane FCE 24304; EXE	Aromatase	Cancer
Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

HY-136064

4,4'-Dimethoxychalcone	Autophagy	Metabolic Disease
4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties.

HY-N2318

Podocarpic acid
TRP Channel Neurological Disease

Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

Podocarpic acid	TRP Channel	Neurological Disease
Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

HY-136175

SNDX-5613	Epigenetic Reader Domain	Cancer
SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding K_i of 0.149 nM and a cell based IC₅₀ of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

HY-A0143

Dihomo-γ-linolenic acid All-cis-8,11,14-Eicosatrienoic acid	Endogenous Metabolite	Cancer Inflammation/Immunology Cardiovascular Disease
Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

HY-14248

Letrozole
CGS 20267
Aromatase Autophagy Cancer

Letrozole is an aromatase inhibitor with an IC₅₀ of 1-13 nM.
HY-U00176

Org30958
Aromatase Metabolic Disease

Org30958 is a potent aromatase inhibitor in vivo.

Letrozole CGS 20267	Aromatase Autophagy	Cancer
Letrozole is an *aromatase* inhibitor with an IC₅₀ of 1-13 nM.

Org30958	Aromatase	Metabolic Disease
Org30958 is a potent *aromatase* inhibitor in vivo.

HY-17577

Berberine chloride hydrate natural Yellow 18 chloride hydrate	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic	Cancer
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.

HY-14649

Retinoic acid Vitamin A acid; All-trans-Retinoic acid; ATRA	RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM.

HY-N6046

Kamebakaurin	NF-κB	Cancer Inflammation/Immunology
Kamebakaurin is a natural compound isolated from Isodon japonicus. Kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50.

HY-N0005

Curcumin Diferuloylmethane; natural Yellow 3; Turmeric yellow	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis	Cancer
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities.

HY-14247

Fadrozole hydrochloride
CGS 16949A
Aromatase Cancer

Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC₅₀ of 6.4 nM.
HY-14247A

Fadrozole
Aromatase Cancer

Fadrozole is a potent, selective and nonsteroidal inhibitor of aromatase with an IC₅₀ of 6.4 nM.
HY-N5012

Eurycomanone
Pasakbumin A
Others Endocrinology

Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

Fadrozole hydrochloride CGS 16949A	Aromatase	Cancer
Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of *aromatase* with an IC₅₀ of 6.4 nM.

Fadrozole	Aromatase	Cancer
Fadrozole is a potent, selective and nonsteroidal inhibitor of *aromatase* with an IC₅₀ of 6.4 nM.

Eurycomanone Pasakbumin A	Others	Endocrinology
Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

HY-112542

Nemadectin CL-287088; LL-F28249 α	Parasite Antibiotic	Infection
Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity.

HY-N1438

Hydroxygenkwanin 7-O-Methylluteolin	Others	Cancer
Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect.

HY-18719E

Endoxifen	Estrogen Receptor/ERR Aromatase	Cancer
Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity.

HY-W012653

4'-Methylacetophenone	Others	Others
4′-methylacetophenone can be used as a fragrance material. 4′-Methylacetophenone is wildly occurs in volatile compounds in food and in some natural complex substances (NCS).

HY-N2302

Fucoxanthin All-trans-Fucoxanthin	Others	Cancer Metabolic Disease Inflammation/Immunology
Fucoxanthin is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.

HY-130640

(S,R,S)-AHPC-Me-C7 ester
E3 Ligase Ligand-Linker Conjugate Cancer

(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-X_L PROTAC degraders.

(S,R,S)-AHPC-Me-C7 ester	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-X_L PROTAC degraders.

HY-125833

Alpha-Naphthoflavone	Aromatase	Cancer
Alpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive *aromatase* inhibitor with an IC₅₀ and a K_i of 0.5 and 0.2 μM, respectively.

HY-41404

Piperonylic acid	Cytochrome P450	Infection
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase.

HY-N0325

DL-Methionine	Parasite	Infection Inflammation/Immunology
DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills *H. rostochiensis* on potato plants.

HY-N0005S

Curcumin D6 Diferuloylmethane D6; natural Yellow 3 D6; Turmeric yellow D6	Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus	Infection Metabolic Disease Inflammation/Immunology
Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-108485

Damnacanthal	Src Apoptosis Fungal	Cancer Infection Inflammation/Immunology
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56^lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans*.

HY-P0244

Dermorphin
Opioid Receptor Neurological Disease

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

Dermorphin	Opioid Receptor	Neurological Disease
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

HY-135235

Cysteine thiol probe	Others	Others
Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites.

HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.
HY-P0244A

Dermorphin TFA
Opioid Receptor Neurological Disease

Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

Ehp inhibitor 2	Ephrin Receptor	Cancer
Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

Dermorphin TFA	Opioid Receptor	Neurological Disease
Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

HY-B1960

Canthaxanthin E 161g; All-trans-Canthaxanthin	Reactive Oxygen Species	Cancer Inflammation/Immunology
Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM.

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM.

HY-18258

Berberine chloride natural Yellow 18 chloride	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic	Cancer
Berberine chloride is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.

HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.
HY-D0889

Glycylglycine
Endogenous Metabolite Metabolic Disease

Glycylglycine is the simplest of all peptides and could function as a gamma-glutamyl acceptor.
HY-13022

CC-401 hydrochloride
CC401 HCl
JNK Cancer

CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with K_i of 25 to 50 nM.
HY-13022A

CC-401
JNK Cancer

CC-401 is a potent inhibitor of all three forms of JNK with K_i of 25 to 50 nM.

SHP836	Phosphatase	Cancer
SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.

Glycylglycine	Endogenous Metabolite	Metabolic Disease
Glycylglycine is the simplest of all peptides and could function as a gamma-glutamyl acceptor.

CC-401 hydrochloride CC401 HCl	JNK	Cancer
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with K_i of 25 to 50 nM.

CC-401	JNK	Cancer
CC-401 is a potent inhibitor of all three forms of JNK with K_i of 25 to 50 nM.

HY-W017212

Methyl cinnamate Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Infection Metabolic Disease
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.

HY-P9906

Bevacizumab
Anti-Human VEGF, Humanized Antibody
VEGFR Cancer

Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity.
HY-113159

Docosapentaenoic acid 22n-3
Endogenous Metabolite Metabolic Disease

Docosapentaenoic acid (22n-3) is a component of phospholipids found in all animal cell membranes.

HY-W017770

Ademetionine disulfate tosylate	Others	Neurological Disease
Ademetionine disulfate tosylate is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-14531

Talarozole R115866	RAR/RXR Cytochrome P450 Autophagy	Inflammation/Immunology
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC₅₀s of 5.4 and 0.46 nM, respectively.

HY-107383

Tetrahydrobiopterin Sapropterin	NO Synthase Endogenous Metabolite	Inflammation/Immunology
Tetrahydrobiopterin is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.

HY-121324

Prometryn
Others Others

Prometryn could improves the control of all weed species and increased lint yield compared with the systems.
HY-12808

STF-118804
Nampt Apoptosis Cancer

STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.
HY-B1216

Oxeladin citrate
Others Inflammation/Immunology

Oxeladin citrate is a cough suppressant, is a highly potent and effective drug used to treat all types of cough of various etiologies.
HY-14817

Indeglitazar
PPM 204
PPAR Metabolic Disease

Indeglitazar (PPM 204) is an orally available PPAR pan-agonist for all three PPARα, PPARδ and PPARγ.

HY-Y0258

Benzocaine	Sodium Channel	Neurological Disease
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na⁺ channel, with an IC₅₀ of 0.8 mM tested with a potential of +30 mV.

HY-12640

Pyrantel pamoate Pyrantel embonate	Parasite Antibiotic	Infection
Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal; acts as a depolarizing neuromuscular blocking agent.

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-N7039

Mogroside IA-(1-3)-glucopyranoside
Others Metabolic Disease

Mogroside IA-(1-3)-glucopyranoside is isolated from Siraitia grosvenorii.

HY-N2022

Castanospermine	Glucosidase	Cancer
Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids).

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-14802

Talarozole R enantiomer (R)-Talarozole	Cytochrome P450	Cancer
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.

HY-113325

NADP	Endogenous Metabolite	Others
NADP is nicotinamide adenine dinucleotide phosphate, acting as a key cofactor for electron transfer in the metabolism of all organisms, being alternately oxidized (NADP⁺) and reduced (NADPH).

HY-B0216

Ethynyl Estradiol 17α-Ethynylestradiol; Ethynylestradiol	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

HY-N0913

Manninotriose	Others	Others
Manninotriose is a novel and important player in the RFO(Raffinose family oligosaccharides) metabolism of red dead deadnettle; potential to improve the side effects of MTX for ALL treatment.

HY-P1486

Angiotensinogen (1-14), human	Endogenous Metabolite	Cardiovascular Disease
Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.

HY-101541

Docosahexaenoic Acid methyl ester Methyl docosahexaenoate; All cis-DHA methyl ester	Others	Neurological Disease
Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

HY-P1486A

Angiotensinogen (1-14), human TFA	Endogenous Metabolite	Cardiovascular Disease
Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.

HY-N0915

Melittoside
Others Inflammation/Immunology

Melittoside is a natural compound.
HY-N0916

Monomelittoside
Danmelittoside
Others Inflammation/Immunology

Monomelittoside is a natural compound.

HY-B0990

Thiostrepton	Bacterial Antibiotic	Infection
Thiostrepton is a natural cyclic oligopeptide antibiotic, is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class.

HY-U00189

Sch412348	Adenosine Receptor	Neurological Disease
Sch412348 is a potent competitive antagonist of the human adenosine A_2A receptor (K_i=0.6 nM) and has >1000-fold selectivity over all other adenosine receptors.

HY-113215

Allotetrahydrocortisol 5a-Tetrahydrocortisol	Endogenous Metabolite	Others
Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes.

HY-N0853

Alisol A
Alisol-A
Autophagy Others

Alisol A is a natural product.
HY-N0149

Salicin
D-(−)-Salicin; Salicoside
COX Cancer Inflammation/Immunology

Salicin is a natural COX inhibitor.
HY-N0935

Ligustrazine hydrochloride
Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride
Others Others

Ligustrazine (hydrochloride) is a natural product.
HY-N0788

Indaconitine
15-Deoxyaconitine
Others Neurological Disease

Indaconitine is a natural product.
HY-N0867

Dodecanoic acid ingenol ester
Others Others

Dodecanoic acid ingenol ester is a natural compound.
HY-N0787

Cryptochlorogenic acid
4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid
Endogenous Metabolite Others

Cryptochlorogenic acid is a natural product.
HY-N0426

Alismoxide
(+)-Alismoxide
Others Others

Alismoxide is a natural product.
HY-N0321

Caftaric acid
trans-Caftaric acid
Others Others

Caftaric acid is a natural product.
HY-N0410

Daucosterol
Eleutheroside A; β-Sitosterol β-D-glucoside
Others Cancer

Daucosterol is a natural sterolin.

HY-15981

Omarigliptin MK-3102	Dipeptidyl Peptidase	Metabolic Disease
Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over all proteases tested (IC50 > 67 μM).

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-N0611

alpha-Boswellic acid
α-Boswellic acid
Others Inflammation/Immunology

alpha-Boswellic acid is a natural product.
HY-N0237

Atractyloside A
Others Others

Atractyloside A is a natural TCM reference compound.
HY-N0854

Alisol F
P-glycoprotein Infection

Alisol F is a natural product.
HY-N1765

L-Praziquanamine
(+)-Praziquanamine
Others Others

L-Praziquanamine is a natural product.
HY-N0941

beta-Mangostin
β-Mangostin
Others Others

beta-Mangostin is a natural product.
HY-N0866

20-Deoxyingenol
Others Others

20-Deoxyingenol is a natural compound.

HY-W004260

Arachidic acid Icosanoic acid	Endogenous Metabolite	Others
Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue.

HY-16911

AFN-1252 API-1252; Debio 1452	Bacterial Antibiotic	Infection
AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.

HY-N1201

Apigenin 4',5,7-Trihydroxyflavone; Apigenol; C.I. natural Yellow 1	Autophagy Cytochrome P450	Inflammation/Immunology Cancer
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K_i of 2 μM.

HY-12866

Larotrectinib LOXO-101; ARRY-470	Trk Receptor Apoptosis	Cancer
Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).

HY-14608

(S)-Glutamic acid (+)-L-Glutamic acid	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Neurological Disease
(S)-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-N0881

Desacetylcinobufagin
Deacetylcinobufagin
Others Others

Desacetylcinobufagin is a natural compound used for microbial transformation.
HY-N0853A

Alisol A 24-acetate
Alisol-A 24-acetate; Alisol A 24-monoacetate; Alisol A monoacetate
Others Others

Alisol A 24-acetate is a natural product.
HY-N1484

7beta-Hydroxylathyrol
Others Others

7beta-Hydroxylathyrol is a natural product.
HY-N0457

Cichoric Acid
Cichoric acid; Dicaffeoyltartaric acid
Reactive Oxygen Species Others

Cichoric Acid, a natural product, is reported to be antioxidative.

HY-14608A

L-Glutamic acid monosodium salt Monosodium glutamate	iGluR Apoptosis Ferroptosis	Neurological Disease
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-N0257

Epimedin A
Others Others

Epimedin A is a natural compound extracted from Herba Epimedii.
HY-B0134

Bestatin
Ubenimex
Aminopeptidase Bacterial Antibiotic Cancer Infection

Bestatin is a natural, broad-spectrum, and competitive aminopeptidase inhibitor.
HY-W012185

(-)-Sparteine
(-)-Lupinidine
Others Others

(-)-Sparteine is a natural alkaloid isolated from beans.
HY-N0843

Kauniolide
Others Cancer

Kauniolide(81066-45-7) is a natural compound.
HY-N0561

Lathyrol
Others Cancer

Lathyrol is a natural product, and is used for cancer treatment.
HY-N0433

Astragaloside II
Astrasieversianin VIII
Others Others

Astragaloside II is a natural isolated from Astragalus.
HY-17389

Genipin
(+)-Genipin
Autophagy Metabolic Disease Cancer

Genipin is a natural water soluble crosslinking reagent.

HY-N1377

Nevadensin	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive.

HY-N4019

Maohuoside A	Others	Metabolic Disease
Maohuoside A, a single compound isolated from the E. koreanum that potently promotes osteogenesis. Maohuoside A enhances the osteogenesis of bone marrow-derived mesenchymal stem cells via bone morphogenetic protein (BMP) and MAPK signaling pathways.

HY-18732A

L-NMMA acetate Tilarginine acetate; Methylarginine acetate	NO Synthase	Cardiovascular Disease
L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The K_i values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].

HY-136522

S2116	Histone Demethylase Apoptosis	Cancer
S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice.

HY-128607

Mcl1-IN-9
Bcl-2 Family Cancer

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC₅₀ of 446 nM in reengineered BCR-ABL+ B-ALL cells and a K_i of 0.03 nM.

HY-136092

Androsta-1,4,6-triene-3,17-dione	Aromatase	Endocrinology Neurological Disease
Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific *aromatase* inhibitor with a K_i of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory.

HY-N6903

Geoside
Gein; Eugenyl vicianoside
Others Metabolic Disease

Geoside (Gein) is a natural compound isolated from stevia rebaudiana.
HY-N0696

Sipeimine
Imperialine
Others Others

Sipeimine is a natural product isolated from Fritillaria ussuriensis.
HY-113268

Biotin sulfone
Endogenous Metabolite Metabolic Disease

Biotin sulfone is first isolated as a natural metabolite of biotin.
HY-N4101

Styraxlignolide F
Others Cancer

Styraxlignolide F is a natural compoundisolated from Styrax japonica.
HY-B1000A

L-SelenoMethionine
Endogenous Metabolite Apoptosis Cancer

L-SelenoMethionine is a major natural food-form of selenium.
HY-N2476

Adynerin
Others Others

Adynerin is a natural steroid found in the herbs of Nerium oleander.
HY-N0213

Peiminine
Verticinone; Raddeanine
Autophagy Inflammation/Immunology Cancer

Peiminine(Verticinone; Raddeanine) is a natural compound with anti-inflammatory activity.

HY-N0560

Oroxylin A Baicalein 6-methyl ether; 6-Methoxybaicalein	HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease	Cancer
Oroxylin A is a natural active flavonoid with strong anticancer effects.

HY-N4234

Angelol K
Others Inflammation/Immunology

Angelol K is a natural product from Chinese angelica.
HY-Y0585

D-(-)-Mandelic acid
Others Others

D-(-)-Mandelic acid is a natural compound isolated from bitter almonds.
HY-N0432

Astragaloside I
Astrasieversianin IV; Cyclosieversioside B
Others Others

Astragaloside I is a natural product isolated from Astragalus.
HY-N0772

Isomangiferin
Influenza Virus Infection

Isomangiferin, a natural product, is reported to have antiviral activity.
HY-N0434

Astragaloside III
Others Others

Astragaloside III is a natural product isolated from Astragalus.
HY-N1387

4-Methoxycinnamic acid
Endogenous Metabolite Inflammation/Immunology

4-Methoxycinnamic acid is detected as natural phenylpropanoid in A. preissii.

HY-N0726

Dracorhodin perchlorate Dracohodin perochlorate	Apoptosis	Cancer
Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product extracted from a natural medicine Dragon's blood. Dracorhodin perchlorate (Dracohodin perochlorate) inhibits cell proliferation, induces cell cycle arrest and apoptosis .

HY-111778

EHMT2-IN-1	Histone Methyltransferase	Cancer
EHMT2-IN-1 is a potent EHMT inhibitor, with IC₅₀s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2. Used in the research of blood disorder or cancer.

HY-111904

EHMT2-IN-2	Histone Methyltransferase	Cancer
EHMT2-IN-2 is a potent EHMT inhibitor, with IC₅₀s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2. Used in the research of blood disease or cancer.

HY-B0845

Prochloraz BTS 40542	Fungal Estrogen Receptor/ERR Androgen Receptor Aryl Hydrocarbon Receptor
Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC₅₀ = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC₅₀s = 25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC₅₀ = 1 μM).

HY-N0046

Notoginsenoside Fe
Notoginseng triterpenes; Ginsenoside Mb
Others Others

Notoginsenoside Fe is a natural compound isolated from Panax japlcus var.
HY-113440

5-Methoxytryptophol
Endogenous Metabolite Neurological Disease

5-Methoxytryptophol is a natural indole present in the pineal gland.
HY-N3524

Calycanthoside
Others Inflammation/Immunology

Calycanthoside is a natural compound isolated from Angelica tenuissima.
HY-N0668

Rubusoside
Others Others

Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.
HY-N0156

Oleanolic Acid
Oleanic acid; Caryophyllin
Autophagy Endogenous Metabolite HIV Cancer

Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.
HY-N0879

Pseudobufarenogin
ψ-Bufarenogin
Others Cancer

Pseudobufarenogin is a natural compound extracted from toad species with unknown details.
HY-N1958

Syringaresinol diglucoside
Syringaresinol-di-O-glucoside
Others Metabolic Disease

Syringaresinol diglucoside is a natural compound from bamboo leaves.
HY-N6817

Isoagarotetrol
Others Others

Isoagarotetrol is a natural product isolated from agalwood.
HY-N6907

Dahurinol
Others Inflammation/Immunology

Dahurinol is a natural compound isolated from Cimicifuga acerina.
HY-N0855

Alisol G
Alisol-G; 25-Anhydroalisol A
Others Others

Alisol G is a natural product extracted from Rhizoma Alismatis.
HY-N1118

Triptotriterpenic acid A
Abrusgenic acid; Maytenfolic acid
Others Metabolic Disease

Triptotriterpenic acid A is a natural product from Tripterygium wilfordii.
HY-N4325

Onjisaponin Z
Others Neurological Disease

Onjisaponin Z is a natural product isolated from Radix Polygalae.
HY-N2469

Xylotriose
Others Others

Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor.

HY-N3841

ε-Viniferin epsilon-Viniferin	Cytochrome P450	Inflammation/Immunology
ε-Viniferin, the dimer of Resveratrol and isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant capacity.

HY-21088

3-Amino-2-piperidinone Cyclo-ornithine	Endogenous Metabolite	Metabolic Disease
3-aminopiperidine-2-one is a metabolite from all living organisms. 3-aminopiperidine-2-one is a delta-lactam that is 2-piperidone substituted at position 3 by an amino group.

HY-N0167

Gynostemma Extract
Ginsenoside C-Mx1; Gynosaponin I; Gypenoside IX
Endogenous Metabolite Cancer

Gynostemma Extract (Ginsenoside C-Mx1) is a natural product.
HY-N0597

Panaxatriol
Others Others

Panaxatriol is a natural product that can relieve myelosuppression induced by radiation injury.
HY-113293A

Estrone sulfate potassium
Endogenous Metabolite Endocrinology Cancer

Estrone sulfate potassium is a natural endogenous steroid and is an estrogen ester and conjugate.
HY-N0212

Peimine
Verticine; Dihydroisoimperialine
Others Inflammation/Immunology

Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.
HY-N1366

Herniarin
7-Methoxycoumarin; Methyl umbelliferyl ether
Others Cancer

Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
HY-N2212

Arctigenin 4'-O-β-gentiobioside
Others Inflammation/Immunology Metabolic Disease

Arctigenin 4'-O-β-gentiobioside is a natural compound isolated from Arctigenin.
HY-N0796

Procyanidin B2
Proanthocyanidin B2
Reactive Oxygen Species Cancer

Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.
HY-N0519

Calycosin
Cyclosin
Apoptosis Cancer

Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.
HY-N5027

Oxyberberin
Berlambine; 8-Oxoberberine; Ketoberberine
Others Infection

Berlambine is a natural alkaloid isolated from many plants.
HY-N2285

Fabiatrin
Others Inflammation/Immunology

Fabiatrin is a natural product isolated from Przewalskia tangutica.
HY-N2440

Gypenoside A
Others Metabolic Disease

Gypenoside A is a natural compound isolaated from Gynostemma pentaphyllum Makino.
HY-N7257

Glucosinalbate
Others Metabolic Disease

Glucosinalbate is a natural product isolated from Arabidopsis thaliana.
HY-N0476

Wilforlide A
Regelide; Abruslactone A
Others Inflammation/Immunology

Wilforlide A is a natural product, separated from the ethanolic extract of tripterygium wilfordii.
HY-N2186

Leucoside
Others Others

Leucoside is a natural compound isolated from tea seed extract.
HY-N6930

Shikonofuran A
Others Metabolic Disease

Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.
HY-N0210

D-Galactose
D-(+)-Galactose
Endogenous Metabolite Neurological Disease

D-Galactose is a natural aldohexose and C-4 epimer of glucose.
HY-N6959

Osmundacetone
Others Metabolic Disease

Osmundacetone is a natural product isolated from Osmundae Rhizoma.
HY-N7522

Salvianolic acid E
Others Others

Salvianolic acid E is a natural compound isolated from Salvia miltiorrhiza.
HY-N6859

Lucidenic acid LM1
Others Others

Lucidenic acid LM1 is a natural triterpenoid isolated from Ganoderma lucidum.
HY-N0936

Coixol
6-Methoxy-2-benzoxazolinone; 6-MBOA
Others Others

Coixol is a natural product extracted from Coix Lachryma-Jobi var.
HY-N7037

Osthol hydrate
Others Metabolic Disease

Osthol hydrate is a natural product isolated from F. schottiana.

HY-N0077

Ginkgolic Acid Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid	E1/E2/E3 Enzyme	Cancer
Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

HY-N0871

Ingenol-3,4,5,20-diacetonide
Ingenol 3,4:5,20-bisacetonide
Others Others

Ingenol-3,4,5,20-diacetonide is a natural compound.
HY-N0900

Cimiracemoside D
Others Infection

Cimiracemoside D is a natural product found in Actaea racemosa with unknown details.
HY-N0868

20-O-Acetylingenol-3-angelate
Euphorbia factor Pe1
Others Others

20-O-Acetylingenol-3-angelate is a natural compound.

HY-N0086

N6-Methyladenosine 6-Methyladenosine; N-Methyladenosine	Endogenous Metabolite Influenza Virus	Infection
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-13271

Tubastatin A Hydrochloride Tubastatin A HCl; TSA HCl	HDAC Autophagy Apoptosis	Cancer
Tubastatin A (Hydrochloride) is a potent and selective HDAC6 inhibitor with IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).

HY-13271A

Tubastatin A	HDAC Autophagy Apoptosis	Cancer
Tubastatin A is a potent and selective HDAC6 inhibitor with IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).

HY-12866A

Larotrectinib sulfate LOXO-101 sulfate; ARRY-470 sulfate	Trk Receptor Apoptosis	Cancer
Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).

HY-108472

Loxoribine 7-Allyl-8-oxoguanosine; RWJ 21757	Toll-like Receptor (TLR) Influenza Virus	Cancer Infection
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.

HY-136523

S2157	Histone Demethylase Apoptosis	Cancer
S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-N2286

Kushenol I
Others Inflammation/Immunology

Kushenol I is a natural compound isolated from the roots of Sophora flavescens.
HY-N0243

Theaflavin
Influenza Virus Endogenous Metabolite Infection

Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.
HY-N4296

Isosakuranin
Others Metabolic Disease

Isosakuranin is a natural product derived from the fruits of Paliurus ramosissimus.
HY-N0442

5-O-Methylvisammioside
4'-O-β-D-Glucosyl-5-O-methylvisamminol
Others Others

5-O-Methylvisammioside is a natural product isolated from Saposhnikovia Divaricata.
HY-131108

β-Aspartylaspartic acid
Others Others

β-Aspartylaspartic acid is a natural compound found in Asparagus (Asparagus officinalis) Shoots.
HY-N0873

Sagittatoside A
Icariin-A
Others Others

Sagittatoside A is a natural compound isolated from traditional Chinese herb Yinyanghuo (Herba Epimdii).
HY-N6912

Regelidine
Others Metabolic Disease

Regelidine is a natural product isolated from the stems of Tripterygium regelii.
HY-N2161

Apiopaeonoside
Others Infection Inflammation/Immunology

Apiopaeonoside is a natural product isolated from the root of Paeonia suffruticosa.
HY-N1155

Theviridoside
Others Cardiovascular Disease

Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.
HY-N0744

Senkyunolide H
Others Cancer

Senkyunolide H is a natural compound isolated from Ligusticum chuanxiong Hort.
HY-N0852

Benzoylpaeoniflorin
Others Cardiovascular Disease

Benzoylpaeoniflorin is a natural product; may treat coronary heart disease by decreasing apoptosis.
HY-N2559

Maltohexaose
Amylohexaose
Endogenous Metabolite Others

Maltohexaose is a natural saccharide, and can be produced from amylose, amylopectin and whole starch.
HY-N6991

11-Deoxymogroside IIIE
Others Metabolic Disease

11-Deoxymogroside IIIE is a natural product isolated from Siraitia grosvenorii.
HY-W016289

Antiarol
3,4,5-Trimethoxyphenol
Others Others

Antiarol (3,4,5-Trimethoxyphenol) is a natural compound isolated from Salmaliamalabaricum.
HY-N2089

Ligupurpuroside C
Others Inflammation/Immunology

Ligupurpuroside C is a natural phenylethanoid glycoside isolated from Kudingcha.
HY-N0260

Epmedin C
Epimedin-C; Baohuoside-VI
Others Inflammation/Immunology

Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.
HY-N7250

(+)-trans-Isolimonene
Others Infection

(+)-trans-Isolimonene is a natural monoterpene isolated from essential oil.
HY-N0903

Dihydrochelerythrine
12,13-Dihydrochelerythrine
Fungal Infection

Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.
HY-N6915

Mogroside II-A
Others Inflammation/Immunology Metabolic Disease

Mogroside II-A is a natural product isolated from Siraitia grosvenorii.
HY-N1234

Smyrindioloside
Others Inflammation/Immunology

Smyrindioloside is a natural product isolated from the bark of Streblus indicus.
HY-N6874

Ligustrosidic acid
Others Others

Ligustrosidic acid is a natural compound isolated from ligustrum japonicum and ligustrum lucidum.

HY-106019C

Liarozole dihydrochloride R75251 dihydrochloride	Cytochrome P450	Cancer Inflammation/Immunology
Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Liarozole dihydrochloride prevents the catabolism of retinoic acid via inhibition of 4-hydroxylase and exhibits retinoid sparing and retinoid-mimetic effects in vivo. Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

HY-P1783

M2e, human	Influenza Virus	Infection
M2e, human, consisting of the 23 extracellular residues of M2 (the third integral membrane protein of influenza A), has been remarkably conserved in all human influenza A, which is a valid and versatile vaccine candidate to protect against any strain of human influenza A.

HY-N0573

Umbelliferone 7-Hydroxycoumarin; Hydrangin; NSC 19790	Endogenous Metabolite Apoptosis	Cancer
Umbelliferone, a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.

HY-N1599

16-Epivoacarpine
16-epi-Voacarpine
Others Others

16-Epivoacarpine is a natural alkaloid isolated from Gelsemium elegans.
HY-N3637

Cotoin
Others Metabolic Disease

Cotoin is a natural product isolated from the stem bark of Garcinia virgate.

HY-B0927

Hydrastine (-)-β-Hydrastine; (1R,9S)-β-Hydrastine	Others	Others
Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

HY-16059

Arglabin
(+)-Arglabin
NOD-like Receptor (NLR) Cancer

Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound.

HY-B1000

Selenomethionine Seleno-DL-methionine; DL-Selenomethionine	Autophagy Endogenous Metabolite	Cancer
Selenomethionine is a naturally occurring amino acid containing selenium, is a common natural food source of selenium.

HY-N4279

Gentisin
Others Others

Gentisin is a natural compound isolated from Gentianae radix (Gentianaceae) with mutagenic activities.

HY-N0056

Isochlorogenic acid A 3,5-Dicaffeoylquinic acid; 3,5-CQA	Reactive Oxygen Species HBV Endogenous Metabolite	Inflammation/Immunology
Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with antioxidant and anti-inflammatory activities .

HY-13930

Miquelianin Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Endogenous Metabolite	Cancer
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.

HY-N0695

Schisantherin B
Gomisin-B; Wuweizi ester-B; Schisantherin-B
Amyloid-β Inflammation/Immunology

Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a natural product.
HY-N2200

Precyasterone
Others Inflammation/Immunology

Precyasterone is a natural product isolated from the dried roots of Cyathula capitata.
HY-N0748

Oxypaeoniflorin
Others Others

Oxypaeoniflorin is a natural product derived from Radix Paeoniae Rubra and Radix Paeoniae Alba.
HY-N2446

Kakuol
Fungal Infection

Kakuol is a natural compound isolated from the rhizomes of Asarum sieboldii. Antifungal activity.

HY-N0902

Dihydrosanguinarine 13,14-Dihydrosanguinarine	Others	Infection
Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal and anticancer activity.

HY-N0874

Sagittatoside B
Others Others

Sagittatoside B is a natural compound isolated from traditional Chinese herb Yinyanghuo (Herba Epimdii).

HY-128602

c-Kit-IN-2	c-Kit	Cancer
c-Kit-IN-2 is a c-KIT inhibitor with an IC₅₀ of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI₅₀s of 3, 1, and 2 nM, respectively.

HY-11012

TDZD-8 GSK-3β Inhibitor I; NP 01139	GSK-3	Cancer
TDZD-8 is an inhibitor of GSK-3β, with an IC₅₀ of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC₅₀s of >100 μM.

HY-111791

ACY-1083	HDAC	Cancer
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC₅₀ of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

HY-N1372

(R)-Fangchinoline Thalrugosine; Thaligine	Bacterial Antibiotic	Cancer Infection Inflammation/Immunology Cardiovascular Disease
(R)-Fangchinoline (Thalrugosine), a alkaloids from genus Stephania，exhibits antimicrobial and hypotensive activity. The roots and stems of several plants from genus Stephania are all used as traditional Chinese medicine and have been used for treatment of fever, diarrhea, dyspepsia and urinary disease.

HY-N0859

Schisanhenol
Schizanhenol; Gomisin-K3
Others Cancer

Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.

HY-N0007

Bisdemethoxycurcumin Curcumin III; Didemethoxycurcumin	Apoptosis Autophagy	Cancer
Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.

HY-15733

Lucidin
NSC 30546
Others Cancer

Lucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.
HY-N0870

Ingenol-5,20-acetonide-3-O-angelate
Ingenol 5,20-acetonide 3-angelate; Ingenol 3-angelate 5,20-acetonide
Others Others

Ingenol-5,20-acetonide-3-O-angelate is a natural compound.

HY-N1944

Nerolidol	Bacterial Fungal Parasite Endogenous Metabolite	Cancer Infection
Nerolidol is a natural membrane-active sesquiterpene, with antitumor, antibacterial, antifungal and antiparasitic activity.

HY-N0669

Stevioside
Others Cancer

Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana, with anticancer activity.
HY-128387

2,3-Butanediol
Endogenous Metabolite Infection

2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.
HY-N6260

4-O-beta-Glucopyranosyl-cis-coumaric acid
Others Others

4-O-beta-Glucopyranosyl-cis-coumaric acid is a natural compound isolated formn Nelumbo nucifera Gaertn.

HY-N0662

Amentoflavone Didemethyl-ginkgetin	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV	Cancer
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects.

HY-N4123

Orcinol gentiobioside
Others Others

Orcinol gentiobioside (compound 4) is a natural product isolated from the rhizomes of C. breviscapa.
HY-N0467

Rebaudioside C
Dulcoside B
Endogenous Metabolite Others

Rebaudioside C(Dulcoside B) is used as natural sweeteners to diabetics and others on carbohydrate-controlled diets.
HY-N1276

Secoisolariciresinol Monoglucoside
Others Neurological Disease

Secoisolariciresinol Monoglucoside is a natural product isolated from the seeds of Linum usitatissimum L..
HY-N0123

Aloin
Aloin-A; Barbaloin-A
Others Cancer

Aloin(Aloin-A; Barbaloin-A) is a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities.
HY-N4319

Jasminoside B
Others Inflammation/Immunology

Jasminoside B is a natural compound isolated from the rhizomes of Asarum sieboldii with immunosuppressive activity.

HY-B0183

Ellagic acid	Casein Kinase Reactive Oxygen Species Endogenous Metabolite	Cancer Neurological Disease
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-120548

KBU2046	Others	Cancer
KBU2046 is an oral, highly selective inhibitor of cell motility and cell invasion in vitro. KBU2046 binds chaperone heterocomplexes, selectively alters binding of client proteins that regulate motility, and lacks all of the hallmarks of classical HSP90 inhibitors. KBU2046 inhibits cancer metastasis and prolongs life.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-W008350

(+)-Sparteine	nAChR	Neurological Disease
(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.

HY-N0182

Fisetin	Sirtuin PPAR TNF Receptor	Metabolic Disease Inflammation/Immunology Neurological Disease Cancer
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-N4324

cis-p-Menthan-1,8-diol
4-p-Menthan-1,8-diol
Others Infection

cis-p-Menthan-1,8-diol is a natural menthane monoterpenoid.

HY-N0875

IKarisoside A Icarisoside-A; Baohuoside II	Others	Inflammation/Immunology
IKarisoside A(Icarisoside-A) is a natural compound isolated from Epimedium koreanum (Berberidaceae); has anti-inflammatory properties.

HY-116284

Methyl β-D-glucopyranoside
Methyl β-D-glucoside
Others Others

Methyl β-D-glucopyranoside is used to synthesize natural glycophenolics via enzymatic caffeoylation.

HY-N1428

Citric acid	Apoptosis Bacterial Endogenous Metabolite Antibiotic	Cancer Infection Metabolic Disease Inflammation/Immunology Cardiovascular Disease
Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer.

HY-15459

Cabazitaxel XRP6258; RPR-116258A; taxoid XRP6258	Microtubule/Tubulin Autophagy	Cancer
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-N0860

Schisantherin E Schizantherin-E	Others	Inflammation/Immunology
Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.

HY-N6889

Rebaudioside I
Others Others

Rebaudioside I is a natural non-claoric sweetener isolated from S. rebaudiana Morita.
HY-N0571

Purpurin
Fungal Bacterial Antibiotic Infection Neurological Disease

Purpurin is a natural anthraquinone compound from Rubia tinctorum L.. Purpurin has antidepressant-like effects.
HY-N1899

p-Hydroxy-5,6-dehydrokawain
Others Others

p-Hydroxy-5,6-dehydrokawain is a natural compound isolated from Kawain.

HY-W012980

3-Methylbutanoic acid	Endogenous Metabolite	Metabolic Disease
3-Methylbutanoic acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.

HY-N0887

Isoastragaloside I Isoastragaloside-I	Others	Metabolic Disease
Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.

HY-N0125

Diosmetin
Cytochrome P450 Cancer

Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-A0210

Cerulenin	Fatty Acid Synthase (FASN) Fungal Antibiotic	Infection Metabolic Disease
Cerulenin, the best known natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus.

HY-N0078

Ginkgolic Acid C13:0 Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid	Others	Infection
Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S.

HY-P1577

Dermorphin Analog	Opioid Receptor	Inflammation/Immunology
Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide μ-opioid receptor agonist found in amphibian skin.

HY-P1783A

M2e, human TFA	Influenza Virus	Infection
M2e, human TFA, consisting of the 23 extracellular residues of M2 (the third integral membrane protein of influenza A), has been remarkably conserved in all human influenza A. M2e, human TFA is a valid and versatile vaccine candidate to protect against any strain of human influenza A.

HY-N0204

Pulchinenoside A Anemoside A3	Others	Others
Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.

HY-W001963

Pyrrole-2-carboxylic acid
Endogenous Metabolite Infection

Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov.
HY-19531

9-Azido-Neu5DAz
Others Others

9-Azido-Neu5DAz is a non-natural bifunctional carbohydrates as imaging agent.
HY-N6820

Iristectorin A
Others Cancer

Iristectorin A, a natural product from Iris tectorum, has anti-cancer activities in breast cancer.
HY-N2114

Sedanolide
Autophagy Inflammation/Immunology

Sedanolide, a natural compound occurring in edible umbelliferous plants, possesses anti-inflammatory and antioxidant activities.

HY-N0184A

Dipotassium glycyrrhizinate	Virus Protease	Inflammation/Immunology
Dipotassium glycyrrhizinate is a natural compound, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity.

HY-N0537

Xylose D-(+)-Xylose; (+)-Xylose; Wood sugar	Endogenous Metabolite	Others
Xylose, a natural product, can be catalyzed into xylulose by xylose isomerase, and it is the key step for anaerobic ethanolic fermentation of xylose.

HY-10912

Fexaramine
FXR Autophagy Others

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.
HY-N1502

Carboxyatractyloside
Gummiferin
Others Cancer

Carboxyatractyloside is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport.

HY-N0140

Ursolic acid Prunol; Urson; Malol	Autophagy Endogenous Metabolite	Cancer
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-N0418

Quercitrin Quercetin 3-rhamnoside	Ribosomal S6 Kinase (RSK) Autophagy Reactive Oxygen Species	Inflammation/Immunology
Quercitrin is a natural compound found in Tartary buckwheat with a potential anti-inflammation effect that is used to treat heart and vascular conditions.

HY-N5128

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside
Others Others

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside is a natural flavanone compound.

HY-N1318

Salvigenin	Autophagy	Cancer Inflammation/Immunology Neurological Disease
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties.

HY-17583

Griseofulvin	Fungal Apoptosis Antibiotic	Infection Cancer
Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.

HY-N5098

Arenobufagin 3-hemisuberate
Others Cardiovascular Disease

Arenobufagin 3-hemisuberate is a natural compound as a cardiotonic steroid isolated from the skin of Japanese toad.
HY-N0658

L-Threonine
Endogenous Metabolite Others

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.

HY-N0841

Bruceine A Dihydrobrusatol; NSC310616	Parasite Antibiotic	Infection
Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.

HY-N2176

S-(+)-Marmesin
(+)-Marmesin; (S)-Marmesin
COX Lipoxygenase Others

S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.

HY-N7035

Wogonin 7-O-beta-D-glucuronide methyl ester Wogonoside methyl ester	Others	Metabolic Disease
Wogonin 7-O-beta-D-glucuronide methyl ester is a natural compound isolated from Huanglian Jiedutang.

HY-P2315

Human β-defensin-1 HβD-1	Antibiotic Bacterial	Infection
Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria.

HY-B0389A

D-Glucose-13C6 Glucose-13C6	Endogenous Metabolite	Metabolic Disease
D-Glucose-13C6 is a tracer used to trace glucose-related synthetic catabolism, is a low-cost alternative with the significant advantage that the sixth isotope of natural glucose has virtually zero natural abundance, which facilitates isotopomer analysis with <1% labeled glucose in the infusate.

HY-115475

SW-100	HDAC	Neurological Disease
SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier.

HY-118743

KMN-80	Prostaglandin Receptor	Metabolic Disease
KMN-80, a derivative of PGE1 (HY-B0131), is a selective and potent agonist of EP₄ receptor with an IC₅₀ and a K_i of 3 nM and 2.35 nM, respectively. KMN-80 is against EP₃ receptor with an IC₅₀ of 1.4 μM and >10 μM for all other prostanoid receptors.

HY-B0183A

Ellagic acid (hydrate)	Casein Kinase	Cancer
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-N0889

Ginkgetin	Others	Inflammation/Immunology Cancer
Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L; effects of anti-inflammation and anticancer have been reported.

HY-N2522

Carboxyatractyloside dipotassium Gummiferin dipotassium	Others	Others
Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport.

HY-N6067

Primin
Bacterial Cancer Infection

Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimicrobial and antitumour properties.

HY-N0424

Cycloastragenol Cyclogalagenin; Cyclogalegenin; Cyclogalegigenin	Others	Others
Cycloastragenol, a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties.

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Parasite Ferroptosis	Infection
Dihydroartemisinic acid (Dihydroqinghao acid), isolated as a natural product from Artemisia annua, is a biosynthetic precursor to the antimalarial agent Artemisinin.

HY-N0362

Columbianadin	Apoptosis	Inflammation/Immunology Cancer
Columbianadin, a natural coumarin from, is known to have various biological activities including anti-inflammatory and anti-cancer effects.

HY-N2505

Iristectorigenin A
Others Inflammation/Immunology

Iristectorigenin A is a natural isoflavone isolated from B. chinensis rhizomes. Iristectorigenin A shows antioxidant activity.
HY-N1950

Hispidulin
Dinatin
Pim Cancer

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-N2392

Kukoamine A	Parasite	Infection Cardiovascular Disease
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (K_i, 1.8 μM), with antihypertensive activity.

HY-N1405

Cucurbitacin I
Elatericin B; JSI-124; NSC-521777
STAT JAK Cancer

Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
HY-N2842

α-Amyrin acetate
Others Inflammation/Immunology

α-Amyrin acetate, a natural triterpenoid, has anti-inflammatory activity, antispasmodic profile and the relaxant effect.
HY-W050154

Kojic acid
Parasite Infection

Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent.
HY-W010178

4-Methyloctanoic acid
Others Others

4-Methyloctanoic acid is a natural compound mainly responsible for the characteristic goaty sheepy flavour of sheep and goat milk.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-N0862

Harringtonine	Influenza Virus	Cancer Infection
Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC₅₀ of 0.24 μM.

HY-N0628

Kaempferitrin Lespedin; Lespenephryl	Insulin Receptor	Cancer Metabolic Disease Endocrinology
Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.

HY-N0739

Betaine hydrochloride Betaine chloride	Others	Others
Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.

HY-111911

Xanthocillin X permethyl ether
Others Neurological Disease

Xanthocillin X permethyl ether is a natural compound isolated from fungal extracts, with Aβ-42 lowering activity.
HY-N2239

6-Methoxykaempferol 3-O-Rutinoside
Others Neurological Disease

6-Methoxykaempferol 3-O-Rutinoside is a natural product isolated from the herbs of Pilocarpus pennatifolius.

HY-N3670

Cycloolivil Isoolivil	Others	Cardiovascular Disease
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive tree. Antioxidant and Antiaggregant effects.

HY-N3373

Loganetin	Bacterial	Infection
Loganetin is a non-toxic natural product that may be applied in the antibacterial drug development for treating multidrug-resistant Gram negative infections.

HY-N0714

Berbamine	NF-κB Autophagy	Cancer
Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .

HY-100765

BI-0252	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC₅₀ of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.

HY-N2181

Acetylshikonin	Cytochrome P450 AChE	Cancer Inflammation/Immunology
Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin is a non-selective cytochrome P450 inhibitor against all P450s (IC₅₀ values range from 1.4-4.0 μM). Acetylshikonin is an AChE inhibitor and exhibits potent antiapoptosis activity.

HY-N7539

Cognac oil	Others	Metabolic Disease
Cognac oil, mainly found in wine lees, has unique fatty acid profiles, including Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), Oleic acid (8.3%) and other fatty acids. Cognac oil leads to a general increase in the permeation of R6G (Rhodamine 6G) across all the membranes.

HY-120508

Pivanex AN-9; Pivalyloxymethyl butyrate	HDAC Bcr-Abl Apoptosis	Cancer Inflammation/Immunology
Pivanex (AN-9), a derivative of Butyric acid, is an orally active HDAC inhibitor. Pivanex down-regulates bcr-abl protein and enhances apoptosis. Pivanex has antimetastic and antiangiogenic properties.

HY-N7058

cis-Jasmone	Others	Others
Cis-Jasmone is a plant-derived natural product. Cis-Jasmone is constitutively released by many flowers and sometimes by leaves as an attractant for pollinators or as a chemical cue for host location by insect flower herbivores. Cis-Jasmone treatment of crop plants not only induces direct defense against herbivores, but also induces indirect defense by releasing VOCs that attract natural enemies.

HY-N1369

Menthol	Others	Neurological Disease
Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca⁺⁺ currents of neuronal membranes.

HY-N0054

Osthole Osthol; Ostol; NSC 31868	Histamine Receptor Apoptosis Parasite HBV	Cancer Infection Endocrinology Inflammation/Immunology Cardiovascular Disease
Osthole is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H₁ receptor activity. Osthole also suppresses the secretion of HBV in cells.

HY-N0064

Macelignan (+)-Anwulignan; Anwuligan	Bacterial	Neurological Disease
Macelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.

HY-N0882

Desacetylcinobufotalin Deacetylcinobufotalin	Apoptosis	Cancer
Desacetylcinobufotalin is a natural compound; apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml.

HY-N0891

Tubeimoside II Tubeimoside-B	Others	Cancer
Tubeimoside II(Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.

HY-109044

Tapinarof GSK2894512; Benvitimod; WBI 1001	Aryl Hydrocarbon Receptor	Inflammation/Immunology
Tapinarof (GSK2894512) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC₅₀ of 13 nM. Tapinarof resolves skin inflammation in mice.

HY-N2033

Chebulinic acid	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-N6069

Raspberry ketone glucoside	Others	Inflammation/Immunology
Raspberry ketone glucoside is a natural product in raspberry fruit. Raspberry ketone glucosidev has the inhibitory effect on the melanin synthesis.

HY-B0923

Danthron Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	AMPK Autophagy Bacterial Virus Protease	Cancer
Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

HY-Y0152

Cinchonine (8R,9S)-Cinchonine; LA40221	Apoptosis Parasite	Cancer
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.

HY-N0398

Sec-O-Glucosylhamaudol	Opioid Receptor	Neurological Disease
Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect.

HY-N0168

Hesperetin	p38 MAPK Apoptosis Autophagy	Neurological Disease Cancer
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N0563

Alizarin
Others Others

Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings.

HY-N0174

Cryptotanshinone Cryptotanshinon; Tanshinone c	STAT Autophagy	Cancer
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

HY-N0234

Bavachinin 7-O-Methylbavachin; Bavachinin A	Others	Inflammation/Immunology
Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity.

HY-N0805

Alisol B 23-acetate 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate	Others	Others
Alisol B 23-acetate, a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.

HY-N6890

Tarasaponin VI
Others Metabolic Disease

Tarasaponin VI is a natural product isolated from Aralia elata. Tarasaponin VI shows potent inhibitory activity on ethanol absorption.

HY-W012999

Tiglic acid	Endogenous Metabolite	Others
Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. Tiglic aci has a role as a plant metabolite.

HY-N6833

Rebaudioside M
Others Others

Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a natural non-calorie sweetener isolated from Stevia rebaudiana Bertoni.
HY-N0033

Poliumoside
Others Metabolic Disease

Poliumoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM.

HY-121295

Roseoflavin	Bacterial	Infection
Roseoflavin, a natural pigment originally isolated from Streptomyces davawensis, is an antimetabolite analog of Riboflavin and flavin mononucleotide that has antimicrobial properties.

HY-N1368A

(+)-Borneol d-Borneol	GABA Receptor Endogenous Metabolite	Inflammation/Immunology
(+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC₅₀ of 248 μM.

HY-N0856

Alisol C 23-acetate 23-O-Acetylalisol C; Alisol C monoacetate	Others	Cardiovascular Disease
Alisol C 23-acetate, a natural product extracted from Alisma orientale, can significantly and strongly inhibit DTH response after oral administration.

HY-N2622

Oxypeucedanin hydrate (+)-Oxypeucedanin hydrate	Others	Cancer
Oxypeucedanin hydrate ((+)-Oxypeucedanin hydrate) is a natural product isolated from D. anethifolia. Prangol exhibits mild toxicity on fibroblasts and parental lymphoma cells.

HY-N2182

Episyringaresinol 4'-O-β-D-glncopyranoside	Others	Inflammation/Immunology
Episyringaresinol 4'-O-β-D-glncopyranoside (compound 22), isolated from Alhagi sparsifolia Shap, is a natural potential neuroinflammatory inhibitor.

HY-B0433A

Quinine hydrochloride dihydrate	Parasite	Infection
Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.

HY-N0610

trans-Cinnamic acid trans-3-Phenylacrylic acid	Bacterial Endogenous Metabolite	Infection Cancer
trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1.

HY-Y0790

Cuminaldehyde	Endogenous Metabolite	Cancer
Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity.

HY-B0914A

10-Undecenoic acid zinc salt Zinc undecylenate	Fungal Antibiotic	Infection
10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

HY-W007856

5-Methoxysalicylic acid 5-MeOSA	Others	Others
5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine.

HY-W015307

4-Ethyloctanoic acid	Others	Others
4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive.

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Reactive Oxygen Species	Metabolic Disease Neurological Disease
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-U00097

L-4-Oxalysine hydrochloride	Fungal	Infection Cancer
L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.

HY-N6940

Prosapogenin A Progenin III	Apoptosis	Cancer
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.

HY-N3521

Platycoside G1 Deapi-platycoside E	Others	Others
Platycoside G1, a natural product found in Platycodon grandiflorum, is a triterpenoid saponin. Platycoside G1 has potent antioxidant activities.

HY-N1166

Tephrosin Deguelinol I; Hydroxydeguelin	EGFR	Cancer
Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors.

HY-N0713

Diosmetin-7-O-β-D-glucopyranoside	Others	Others
Diosmetin-7-O-β-D-glucopyranoside is a natural product isolated from the flowers of Chrysanthemum morifolium, with antioxidant activity.

HY-W010533

(E)-2-Methyl-2-pentenoic acid
Others Others

(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin.
HY-N6862

Lucideric acid A
MMP Cancer

Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.

HY-N2338

Cholesterol myristate Cholesteryl myristate; Cholesteryl tetradecanoate	nAChR GABA Receptor Potassium Channel Endogenous Metabolite	Cancer
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

HY-N3033

N-Benzyllinolenamide	FAAH Autophagy	Metabolic Disease
N-Benzyllinolenamide is a natural macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH) with an IC₅₀ of 41.8 μM.

HY-16686

α-Tocopherol phosphate alpha-Tocopherol phosphate; TocP; vitamin E phosphate	Others	Others
α-Tocopherol phosphate is the compound demonstrating the highest vitamin E activity, which is available both in its natural form as RRR-alpha-tocopherol isolated from plant sources.

HY-114286

PXS-5153A	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A could reduce crosslinks and ameliorates fibrosis.

HY-N7054

Volemitol D-Volemitol	Others	Metabolic Disease
Volemitol (D-Volemitol) is a seven-carbon sugar alcohol that fulfills several important physiological functions in certain species of the genus Primula. Volemitol is the major nonstructural carbohydrate in leaves of all stages of development. Volemitol functions as a photosynthetic product, phloem translocate (phloem-mobile), and storage carbohydrate. Volemitol biosynthesis proceeds by a novel, NADPH-dependent, ketose reductase (sedoheptulose reductase).

HY-N0012

Glycitin Glycitein 7-O-β-glucoside	Influenza Virus Bacterial	Cancer Infection
Glycitin is a natural isoflavone isolated from legumes; promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.Glycitin is antibacterial, antiviral and estrogenic.

HY-N0452

Hyperoside	Influenza Virus Fungal	Infection Inflammation/Immunology
Hyperoside, a natural flavonoid, isolated from Camptotheca acuminate, possesses antifungal, anti-inflammatory, anti-viral, anti-oxidative and anti-apoptotic activities.

HY-N0224

Epigoitrin	Influenza Virus	Infection Cancer
Epigoitrin is a natural alkaloid from Isatis indigotica, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling.

HY-N2868

Andropanoside	Others	Metabolic Disease
Andropanoside is a natural product isolated and purified from the herbs of Andrographis paniculata. Andrographis paniculata possesses a protective activity against various liver disorders.

HY-N4068

Glucoraphanin	Reactive Oxygen Species	Cancer
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-N6860

Lucidenic acid C
MMP Cancer

Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.

HY-17434

Boldenone Undecylenate Ba 29038	Androgen Receptor Endogenous Metabolite	Metabolic Disease
Boldenone Undecylenate (Ba 29038) is a synthetic steroid which has a similar effect as the natural steroid testosterone; it is frequently used in veterinary medicine, though it is also used in humans.

HY-N0777

Isorhamnetin-3-O-glucoside	Others	Metabolic Disease
Isorhamnetin-3-O-glucoside, a natural compound widely contained in many vegetables and rice, could be metabolized in intestinal microbiota after digestion.

HY-N2370

24-Hydroxycholesterol	iGluR LXR	Neurological Disease
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

HY-14781

Levomefolic acid 5-MTHF	Endogenous Metabolite Reactive Oxygen Species	Cancer
Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.

HY-N0207

Patchouli alcohol	Bacterial	Infection Inflammation/Immunology Cancer
Patchouli alcohol is a natural tricyclic sesquiterpene extracted from Pogostemon cablin (Blanco) Benth, and exhibits anti-Helicobacter pylori and anti-inflammatory properties.

HY-107324

β-Elemene (-)-β-Elemene; Levo-β-elemene	Apoptosis	Cancer
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma wenyujin with an antitumor activity. β-Elemene can induce cell apoptosis.

HY-100233

IQ-1S free acid	JNK	Cancer Inflammation/Immunology
IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC₅₀ of 2.3±0.41 μM. IQ-1S free acid has binding affinity (K_d values) in the nanomolar range for all three JNKs with K_ds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.

HY-114286A

PXS-5153A monohydrochloride	Monoamine Oxidase	Inflammation/Immunology
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC₅₀ of <40 nM for LOXL2 across all mammalian species and an IC₅₀ of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis.

HY-N7434

N-Nitrosodiethylamine	DNA/RNA Synthesis
N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

HY-129405

N-(Ketocaproyl)-D,L-homoserine lactone	Bacterial	Infection
N-(Ketocaproyl)-D,L-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-D,L-homoserine lactone is a quorum sensing (QS) autoinducer.

HY-N0168A

(Rac)-Hesperetin	p38 MAPK Apoptosis Autophagy	Cancer Neurological Disease
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N6018

Beta-Eudesmol	TRP Channel	Metabolic Disease
Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC₅₀ of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1.

HY-N0361

Dihydrocapsaicin	TRP Channel	Metabolic Disease
Dihydrocapsaicin is a natural capsaicin, acts as a selective TRPV1 agonist, and also increases p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection.

HY-N2487

5-Hydroxy-7-acetoxyflavone
Others Cancer

5-Hydroxy-7-acetoxyflavone, an active natural flavone derivative found in various plant sources, modulates several biological activities.

HY-N2561

Seneciphylline N-Oxide	Others	Cancer
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae).

HY-121471

Chrysoeriol	Others	Metabolic Disease
Chrysoeriol, a natural flavonoid extracted from the tropical plant Coronopus didymus, exhibits potent antioxidant activity. Chrysoeriol shows significant inhibition of lipid peroxidation.

HY-N0144

Piperine Bioperine; 1-Piperoylpiperidine	P-glycoprotein Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC₅₀ value of 61.94±0.054 μg/mL in HeLa cell.

HY-N2840

Allitol Allodulcitol	Others	Cancer Metabolic Disease
Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS.

HY-N6829

Retusin Quercetin-3,3',4',7-tetramethylether	Others	Infection Inflammation/Immunology
Retusin (Quercetin-3,3',4',7-tetramethylether), a natural compound isolated from the leaves of Talinum triangulare, possesses antiviral and anti-inflammatory activities.

HY-13595

Chrysophanol Chrysophanic acid	EGFR	Cancer
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.

HY-U00450

4-O-Methyl honokiol	PPAR NF-κB	Cancer Inflammation/Immunology
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research.

HY-N0124

Dioscin Collettiside III; CCRIS 4123	Autophagy Apoptosis	Cancer
Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.

HY-N6985

Baccatin III	Others	Cancer
Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs.

HY-15464D

(S)-Gossypol acetic acid (S)-(+)-Gossypol acetic acid	Bcl-2 Family	Cancer
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.

HY-N0370

Bergapten 5-Methoxypsoralen	Cytochrome P450 Autophagy	Cancer
Bergapten is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. Bergapten is inhibitory towards mouse and human CYP isoforms.

HY-12076

BMS 777607 BMS 817378	c-Met/HGFR TAM Receptor	Cancer
BMS 777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC₅₀s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

HY-N4317

Ethoxysanguinarine	Apoptosis	Cancer
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting protein phosphatase 2A (CIP2A).

HY-136203

Resveratrol analog 1	IKK Autophagy Mitophagy Sirtuin	Cancer Inflammation/Immunology
Resveratrol analog 1 is an analog of Resveratrol (HY-16561), compound 48. Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

HY-103700B

(Rac)-Azide-phenylalanine	Others	Others
(Rac)-Azide-phenylalanine is a racemate of Azide-phenylalanine. Azide-phenylalanine is a phenylalanine derivative and a non-natural amino acid. Azide-phenylalanine can be site-specifically incorporated into proteins and used to label proteins.

HY-N6017

Bakkenolide A	Others	Cancer
Bakkenolide A is a natural product extracted from Petasites tricholobus. Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.

HY-N4000

Digitonin	Others	Cancer
Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin is an natural detergent.

HY-13938

Iretol	Endogenous Metabolite	Metabolic Disease
Iretol (2,4,6-trihydroxyanisole) is a a degradation product of a glucoside obtained from Iris Jorentina. Iretol is an intermediate in the synthesis of natural isoflavones, such as Tectorigenin, Irigenin and Caviunin.

HY-N6965

Kaempferol-3-O-(6'''-trans-p-coumaroyl-2''-glucosyl)rhamnoside	Others	Metabolic Disease
Kaempferol-3-O-(6'''-trans-p-coumaroyl-2''-glucosyl)rhamnoside is a natural antioxidant from herbal medicines.

HY-N1455

Falcarinol Panaxynol; Carotatoxin	HSP	Cancer
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis.

HY-N1181

Tamarixetin 4'-O-Methyl Quercetin	Endogenous Metabolite	Inflammation/Immunology
Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy.

HY-N1283

Seneciphyllinine	Others	Metabolic Disease
Seneciphyllinine, a pyrrolizidine alkaloid, is isolated from the roots of Gynura japonica. Pyrrolizidine alkaloids are highly hepatotoxic natural chemicals that produce irreversible chronic and acute hepatotoxic effects on human beings.

HY-N0849

Dictamine Dictamnine; Dectamine	Apoptosis Bacterial Fungal	Infection
Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.

HY-N5029

Isofebrifugine	Parasite	Infection
Isofebrifugine, isolated from a Chinese medicinal plant, Chang Shan (Dichroa febrifuga), is a natural quinazolinone alkaloid with important physiological activities and good pharmacological effects. Antimalarial effect.

HY-N7011

Epicorynoxidine	Others	Inflammation/Immunology
Epicorynoxidine is a natural alkaloid isolated from the herb Corydalis tashiroi. Epicorynoxidine shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL.

HY-N0163

Magnolol	RAR/RXR PPAR Autophagy Bacterial	Cancer Inflammation/Immunology Neurological Disease Cardiovascular Disease
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-N0417

Cucurbitacin E α-Elaterin; α-Elaterine	CDK Autophagy	Cancer
Cucurbitacin E is a natural compound which from the climbing stem of Cucumic melo L. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

HY-100580

Asaraldehyde Asaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde	COX	Inflammation/Immunology
Asarylaldehyde is a natural COX-2 inhibitor, which isolated from carrot (Daucus carota L.) seeds significantly inhibits cyclooxygenase II (COX-2) activity at IC₅₀ value 100 μg/mL.

HY-N0737

Harmine hydrochloride Telepathine hydrochloride	DYRK 5-HT Receptor	Cancer Neurological Disease
Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM.

HY-N7124

Benzyl acetate	Others	Others
Benzyl acetate is a constituent of jasmin and of the essential oils of ylang-ylang and neroli. Natural sources of Benzyl acetate include varieties of flowers like jasmine (Jasminum), and fruits like pear, apple.

HY-N6022

Byakangelicin	Others	Metabolic Disease
Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones.

HY-N0360

Dihydrotanshinone I	SARS-CoV	Cardiovascular Disease
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-N2445

Flavokawain C	Apoptosis	Cancer
Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells.

HY-136204

Resveratrol analog 2	IKK Autophagy Mitophagy Sirtuin	Cancer Inflammation/Immunology
Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

HY-13407

Gossypol BL 193	Bcl-2 Family	Cancer
Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N6038

Gartanin	Others	Cancer
Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells.

HY-N6661

Verbenone (-)-Verbenone	Others	Infection
Verbenone ((-)-Verbenone) is a natural terpene in leaves of the tree, Suregada zanzibariensis Verdc. Verbenone has anti-aggregation pheromone and interrupts the attraction of bark beetles to their aggregation pheromones.

HY-B2114

Escin	Apoptosis	Inflammation/Immunology Cancer
Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.

HY-W002272

Isocytosine	Nucleoside Antimetabolite/Analog	Others
Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA.

HY-111830

Lignin Lignine	Others	Others
Lignin (Lignine) is a natural complex biopolymer with biodegradable and biocompatible. Lignin is the main component of plant cell walls and is a renewable aromatic polymer. Lignin has strongly antioxidant activity.

HY-N4167

3-O-Methylgalangin Galangin 3-methyl ether; 3-Methylgalangin	Others	Infection
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase.

HY-P2031

Phallacidin	Others
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. Phallacidin binds filamentous actin (F-actin) like phalloidin (Item No. 18039), but contains a carboxyl group for coupling reactions.

HY-N0139

Troxerutin Trihydroxyethylrutin	NOD-like Receptor (NLR)	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

HY-N0876

Arenobufagin	Others	Cancer
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.

HY-N7029

3',4',5',5,7-Pentamethoxyflavone	Others	Cancer
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic drugs by inhibition of Nrf2 pathway.

HY-P0219

Microcystin-LA	Phosphatase	Cancer
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively.

HY-N7117

1,4-Cineole	TRP Channel Endogenous Metabolite	Cancer Inflammation/Immunology
1,4-Cineole is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.

HY-18569

3-Indoleacetic acid Indole-3-acetic acid; 3-IAA	Endogenous Metabolite	Others
3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-N6969

Dicentrine	Adrenergic Receptor	Endocrinology
Dicentrine is a natural product isolated from the plant Lindera megaphylla with antihypertensive effect. Dicentrine is an α₁-adrenoceptor antagonist which has effective against human hyperplastic prostates.

HY-120323

DRI-C21045	TNF Receptor	Inflammation/Immunology
DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC₅₀ of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC₅₀s of 17.1 µM and 4.5 µM, respectively.

HY-108584

Flindokalner BMS-204352	Potassium Channel	Neurological Disease
Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (K_i=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo.

HY-N4202

Dihydrorotenone	Mitochondrial Metabolism Apoptosis	Neurological Disease
Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.

HY-N1472

Levistolide A	Apoptosis	Cancer
Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. Levistolide A can induce apoptosis via ROS-mediated ER stress pathway.

HY-106950

Fosfructose Diphosphofructose; Esafosfan; FDP	Endogenous Metabolite	Cardiovascular Disease
Fosfructose (Diphosphofructose;Esafosfan;FDP) is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma. It acts by stimulating anaerobic glycolysis which generates adenosine triphosphate under ischemic conditions.

HY-N6850

Calenduloside E	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).

HY-125699

Ochratoxin C	Fungal
Ochratoxin C is the ethyl ester analog of ochratoxin A, a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant. Ochratoxin C rarely occurs as an initial natural contaminant due to a transformation from ochratoxin A.

HY-N6994

Isoasatone A	Others	Infection
Isoasatone A is a natural product isolated from the plant Heterotropa takaoi M., with anti-insect activity. Isoasatone A againsts S. litura by acting on cytochrome P450 monoxygenases and glutathione transferases.

HY-N4288

4-Methylesculetin	Glutathione Peroxidase	Inflammation/Immunology Cancer
4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level.

HY-N0737A

Harmine Telepathine	DYRK 5-HT Receptor	Cancer Neurological Disease
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM.

HY-130993

Isatropolone A	Parasite	Infection
Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against *Leishmania donovani* with an IC₅₀ of 0.5 μM.

HY-N2110

Phellopterin	Others	Inflammation/Immunology
Phellopterin is a natural product isolated from P. trifoliata. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.

HY-N2050

1,3,5,8-Tetrahydroxyxanthone Desmethylbellidifolin	Others	Inflammation/Immunology Neurological Disease
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity.

HY-N7247

Thiochrome	mAChR	Metabolic Disease
Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors.

HY-N5083

Saponarin	Others	Inflammation/Immunology
Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake.

HY-W009708

Bis(2-methyl-3-furyl)disulfide	Others	Others
Bis(2-methyl-3-furyl)disulfide, compound (2), is intended to provide a flavoring compound to enhance a natural feeling, a fresh feeling and a milk-rich feeling of a milk-related product.

HY-17510

Gossypol acetic acid (±)-Gossypol-acetic acid; BL 193 (acetic acid)	Bcl-2 Family	Cancer
Gossypol acetic acid ((±)-Gossypol-acetic acid), a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N0819

Raddeanin A	Apoptosis	Cancer
Raddeanin A is a natural triterpenoid saponin component of Anemone raddeana, with anti-cancer activities. Raddeanin A exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway.

HY-N7072

Grape seed extract	Others	Metabolic Disease Inflammation/Immunology
Grape seed extract is a natural product with various health benefits, including anti-inflammatory effect. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase.

HY-18061

Ochromycinone (Rac)-STA-21	STAT Bacterial	Cancer Infection
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.

HY-112724

SHR0302	JAK Apoptosis	Cancer Inflammation/Immunology
SHR0302 is a potent and orally active all members of the JAK family inhibitor, particularly JAK1. The selectivity of SHR0302 for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2. SHR0302 inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. SHR0302 has anti-proliferative and anti-inflammatory effects.

HY-112831

BI-409306	Phosphodiesterase (PDE)	Neurological Disease
BI-409306 is a potent and selective PDE9A inhibitor, with an IC₅₀ of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC₅₀, 1.4 µM), PDE1C (IC₅₀, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC₅₀ all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders.

HY-N6882

Genistein 8-c-glucoside G8CG	Mitochondrial Metabolism Apoptosis	Cancer
Genistein 8-c-glucoside (G8CG) is a natural glucoside isolated from flowers of Lupinus luteus L. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces apoptosis.

HY-15731

Estetrol	Estrogen Receptor/ERR Endogenous Metabolite	Cardiovascular Disease
Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast.

HY-N4093

Astringin trans-Astringin	Others	Cancer
Astringin (trans-Astringin) is a natural glycoside found in the bark of Picea sitchensis and Picea abies (Norway spruce), in Vitis vinifera cell cultures and in wine. Astringin has potent antioxidant capacity and cancer-chemopreventive activity.

HY-119412

Biliatresone	Others	Metabolic Disease
Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model.

HY-W016586

Acivicin AT-125; U-42126	Parasite	Cancer Infection
Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

HY-119931

2-Hydroxychalcone	Bcl-2 Family Apoptosis NF-κB	Cancer Metabolic Disease
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

HY-114325

AcLysValCit-PABC-DMAE-SW-163D	Drug-Linker Conjugates for ADC	Cancer
AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker.

HY-12686

5Z-7-Oxozeaenol FR148083; L783279; LL-Z 1640-2	MAP3K VEGFR	Infection Inflammation/Immunology
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC₅₀s of 8 nM and 52 nM, respectively.

HY-A0282

L-Ornithine L-aspartate	Others	Metabolic Disease
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis.

HY-N0723

Neomangiferin	Others	Metabolic Disease
Neomangiferin is a natural C-glucosyl xanthone isolated from m the dried rhizome of Anemarrhena asphodeloides. Neomangiferin has significant therapeutic effects on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats.

HY-N0295

Protocatechualdehyde Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV	Reactive Oxygen Species Bacterial	Cancer Infection
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.

HY-106950A

Fosfructose trisodium Diphosphofructose trisodium; Esafosfan trisodium; FDP trisodium	Endogenous Metabolite	Cardiovascular Disease
Fosfructose trisodium (Diphosphofructose trisodium;Esafosfan trisodium;FDP trisodium) is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma. It acts by stimulating anaerobic glycolysis which generates adenosine triphosphate under ischemic conditions.

HY-129997

Luteolinidin chloride	Others	Inflammation/Immunology
Luteolinidin is a natural deoxyanthocyanidin, isolated from mosses and ferns. Luteolinidin is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.

HY-N4253

Kudinoside D	Others	Metabolic Disease
Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes.

HY-N0836

Jervine 11-Ketocyclopamine	Hedgehog Smo	Cancer Inflammation/Immunology
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.

HY-N0511

Aristolochic acid B	Others	Cancer
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo.

HY-128851

Coenzyme A	Endogenous Metabolite	Cancer Neurological Disease
Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives.

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis chinensis.

HY-77813

Benzyl isothiocyanate	Bacterial Apoptosis Antibiotic	Cancer Endocrinology
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells.

HY-N4053

Heraclenin	Others	Inflammation/Immunology
Heraclenin, a natural furanocoumarin, isolated from the root parts of the plant Prangos pabularia. Heraclenin significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT).

HY-15464

(R)-(-)-Gossypol AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-P1259A

PR-39 TFA	Proteasome	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 stimulates angiogenesis and inhibits inflammatory responses by specifically blocking degradation of IkappaBalpha and HIF-1alpha by the proteasome.

HY-P1259

PR-39	Proteasome	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 stimulates angiogenesis and inhibits inflammatory responses by specifically blocking degradation of IkappaBalpha and HIF-1alpha by the proteasome.

HY-N0211

Cyasterone	EGFR	Cancer
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors.

HY-N2342

Procyanidin C1	Apoptosis	Cancer
Procyanidin C1 is a natural polyphenol, causes DNA damage, cell cycle arrest, and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells.

HY-N4327

Eurycomalactone	NF-κB	Infection Inflammation/Immunology
Eurycomalactone is a natural product found in Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor, with an IC₅₀ of 0.5 μM. Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.

HY-122586

BRD6989	CDK Interleukin Related	Inflammation/Immunology
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC₅₀ of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes.

HY-N2099

Onjisaponin B	Autophagy	Neurological Disease
Onjisaponin B is a natural product derived from Radix Polygalae. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease.

HY-113046

5-Methyltetrahydrofolic acid 5-Methyl THF	Endogenous Metabolite	Metabolic Disease
5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid.

HY-N2491

Deoxyelephantopin	NF-κB	Cancer
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling.

HY-A0126A

Epoprostenol sodium Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan	Others	Cardiovascular Disease
Epoprostenol sodium (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation.

HY-18085

Quercetin	PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis	Cancer
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

HY-W030319

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate	Others	Others
Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection.

HY-N0722

Neochlorogenic acid trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N1131

Triacetonamine 2,2,6,6-Tetramethyl-4-piperidone	Others	Others
Triacetonamine is useful as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine is an artifact of plant and fungal extracts using acetone and ammonium hydroxide or natural occurrence of ammonium salts in various steps of the isolation procedures. TAA is the main component of the pyrolysis oil.

HY-N2375

L-Quebrachitol	Wnt β-catenin	Metabolic Disease
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.

HY-N1956

Rubiadin-1-methyl ether	NF-κB	Metabolic Disease
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.

HY-15464A

(R)-(-)-Gossypol acetic acid AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N2228

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-EGCG-3''-O-ME	Others	Cancer
(-)-Epigallocatechin-3-(3''-O-methyl) gallate is a natural product isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells.

HY-N6861

Lucidenic acid B	Apoptosis	Cancer
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells.

HY-110105

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective small conductance Ca²⁺-activated K⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca²⁺), and does not affect the Ca²⁺-activated K⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively).

HY-19336

BAZ2-ICR	Epigenetic Reader Domain	Cancer
BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC₅₀s of 130 nM and 180 nM, and K_ds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe.

HY-N3417

Kongensin A	HSP RIP kinase Apoptosis	Cancer Inflammation/Immunology
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.

HY-N0592

Demethyleneberberine	NF-κB AMPK	Metabolic Disease Inflammation/Immunology
Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD).

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-N0368

Linalool	iGluR Apoptosis Endogenous Metabolite	Cancer Cardiovascular Disease
Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity.Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome.

HY-N0146

Quercetin dihydrate	PI3K Apoptosis	Inflammation/Immunology Cancer
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

HY-N1478

Gardenoside	Others	Neurological Disease
Gardenoside is a natural compound found in Gardenia fruits, with hepatoprotective properties. Gardenoside suppresses the pain of chronic constriction injury by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis.

HY-B1125

Glucosamine D-Glucosamine; Chitosamine	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

HY-N0733

Glucosamine hydrochloride D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

HY-N2621

Evodol	Others	Inflammation/Immunology
Evodol is a natural product isolated from the dried and nearly ripe fruits of Euodia rutaecarpa. Evodol shows inhibitory activity against NO production. Evodol possesses larvicidal activity against the Asian tiger mosquitoes with a LC₅₀ value of 32.43 μg/ml.

HY-N1127

Tricin	CMV	Cancer Infection
Tricin is a natural flavonoid present in large amounts in rice bran. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.

HY-N0393

Glabridin	PPAR Reactive Oxygen Species Bacterial	Cancer Infection Inflammation/Immunology
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC₅₀ of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.

HY-10529

Betulinic acid Lupatic acid; Betulic acid	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite	Cancer Infection Inflammation/Immunology
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties. Betulinic acid acts as a new activator of NF-kB.

HY-N0279

Cardamonin Cardamomin; Alpinetin chalcone	NOD-like Receptor (NLR) Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.

HY-N4205

Tetrahydropiperine	Cytochrome P450	Cancer
Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum. Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC₅₀=23 µM).

HY-W015371

Ethyl phenylacetate	Others	Others
Ethyl phenylacetate is a natural flavouring ingredien, and its sensory threshold is near 73 µg/L. Ethyl phenylacetate is a “greener" solvent with low toxicity. Ethyl phenylacetate is a non-mutagenic and is a Kosher food additive. Ethyl phenylacetate gives to the wines a strong honey-like character.

HY-N0022

Isoacteoside Isoverbascoside	Others	Metabolic Disease
Isoacteoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM, compared with those of aminoguanidine (IC50=1,056 μM) and quercetin (IC50=28.4 μM) as positive controls.

HY-120878

CXCR2-IN-2	CXCR	Inflammation/Immunology
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC₅₀=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC₅₀ of 0.04 μM.

HY-19975

RN-1734	TRP Channel	Neurological Disease
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC₅₀s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

HY-N6707

Triacsin C WS 1228A; FR 900190	Others	Infection
Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Triacsin C is found to be highly effective against rotavirus replication.

HY-N0655

D-Pinitol 3-O-Methyl-D-chiro-inositol	Influenza Virus	Infection Inflammation/Immunology Cardiovascular Disease
D-pinitol (3-O-Methyl-D-chiro-inositol) is a natural compound presented in several plants, like Pinaceae and Leguminosae plants. D-pinitol exerts hypoglycemic activity and protective effects in the cardiovascular system. D-pinitol has antiviral and larvicidal activities.

HY-N6966

Ethyl Caffeate	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin.

HY-N0539

Calceolarioside B	Others	Cancer
Calceolarioside B is a natural product isolated from Stauntonia hexaphylla leaves. Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC₅₀ of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC₅₀ of 94.60 μM .

HY-N0487

Glucosamine sulfate D-Glucosamine sulfate	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

HY-N2345

Procyanidin B3	Histone Acetyltransferase	Cancer
Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase).

HY-N0646

Silydianin	Phosphatase	Cancer
Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products.

HY-N0346A

(E)-Ethyl p-methoxycinnamate	COX	Cancer Infection Inflammation/Immunology
(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits COX-1 and COX-2 in vitro with IC₅₀s of 1.12 and 0.83 μM, respectively.

HY-N7516

4'-Hydroxy-2,4-dimethoxychalcone	Parasite Bacterial Fungal	Infection
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity.

HY-N6715

Tenuazonic acid	Influenza Virus Bacterial	Infection
Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective *photosystem II (PSII)* inhibitor.

HY-P1422

Spadin	Potassium Channel	Neurological Disease
Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice.

HY-119424

SP4206	Interleukin Related	Inflammation/Immunology
SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (K_d=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (K_d=10 nM).

HY-112811

PROTAC CDK9 degrader-2	PROTAC CDK	Cancer
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC₅₀ of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC.

HY-N0446

10-Methoxycamptothecin	Others	Cancer
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines.

HY-118482

Sauristolactam Saurolactam	Others	Neurological Disease
Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation.

HY-18085S

Quercetin D5	PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin D5 is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

HY-N0501

11-oxo-mogroside V	Reactive Oxygen Species	Metabolic Disease
11-oxo-mogroside V is a natural sweetener, isolated from the fruits of Momordica grosvenori, exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O₂^-, H₂O₂ and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-121744

PS10	PDHK	Inflammation/Immunology
PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC₅₀ of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (K_d= 239 nM) than for Hsp90 (K_d= 47 μM). PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy.PDK: pyruvate dehydrogenase kinase

HY-129039

Butyrolactone 3	Histone Acetyltransferase	Cancer
Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC₅₀=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC₅₀=0.5 mM)

HY-N0192

Arbutin β-Arbutin	Tyrosinase	Cancer
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with K_i^app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.

HY-107784

Ectoine	Bacterial	Inflammation/Immunology
Ectoine is a natural cell protectant, an amino acid derivate produced by bacteria living under extremely harsh environmental conditions. Ectoine serves as an osmoregulatory compatible solute, increasing the hydration of the skin surface and stabilizing lipid layers, which is useful in skincare. Ectoine demonstrates a good safety profile for the treatment of allergic rhinitis.

HY-N7384

Vitamin B15 Pangamic Acid	Others	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
Vitamin B15 (Pangamic Acid) is a natural, ubiquitously in plant seeds substance and can used be as an agent stimulating cellular respiration. Vitamin B15 contains D-gluconodimethyl amino acetic acid. Vitamin B15 is also a immune-correcting agent. Vitamin B15 can be used for wide range of diseases.

HY-P1422A

Spadin TFA	Potassium Channel	Neurological Disease
Spadin TFA, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin TFA binds specifically to TREK-1 with an affinity of 10 nM. Spadin TFA is an efficient antidepressant in mice.

HY-N4100

Trilobatin	HIV SGLT	Infection
Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

HY-113629

2-Keto-D-Glucose D-Glucosone; D-Arabino-hexos-2-ulose	Others	Infection
2-Keto-D-Glucose (D-Glucosone) is a key intermediate in a secondary metabolic pathway leading to the antibiotic Cortalcerone. 2-Keto-D-Glucose is also an intermediate in the conversion of D-glucose into D-fructose. 2-Keto-D-Glucose is found in various natural sources, including fungi, algae, and shellfish.

HY-N0240

Herbacetin	Others	Cancer
Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis.

HY-N2574

Gitogenin	Glucosidase	Metabolic Disease
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms.

HY-N0288

Lycorine	Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis	Cancer Inflammation/Immunology
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a K_d value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription. Lycorine is also a melanoma vasculogenic inhibitor. Lycorine can be used for the study of prostate cancer and metabolic diseases.

HY-W027968

Coumarin-3-carboxylic Acid 2-Oxochromene-3-carboxylic acid	Others	Cancer
Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line.

HY-N2572

Nepetin 6-Methoxyluteolin	Others	Inflammation/Immunology
Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells.

HY-109714

3,4-Benzocoumarin	Others	Inflammation/Immunology
3,4-Benzocoumarin is a kind of the expanded structure of coumarin derivatives.Coumarin is a chemical compound in the benzopyrone chemical class that can be found in many natural species. Coumarins possess variety of biological activities and unique photophysical properties. 3,4-Benzocoumarin, a AOH‐like compound , has the sensibility of the antibody with an IC₅₀ of 919.2 ng/mL.

HY-10015

PAP-1 5-(4-Phenoxybutoxy)psoralen	Potassium Channel	Inflammation/Immunology
PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC₅₀=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC₅₀=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects.

HY-108596

BL-1249	Potassium Channel	Inflammation/Immunology
BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 potently activates K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) with EC₅₀ values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K_2P subfamilies. BL-1249 exhibits more selective for the bladder (EC₅₀ of 1.26 μM) than vascular tissue (EC₅₀ of 21.0 μM).

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Apoptosis	Cancer
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration.

HY-N7020

Cinobufaginol	Others	Cancer
Cinobufaginol is a natural bufadienolide isolated from toad venom which has been widely used for centuries in China to treat different diseases, especially for cancer. Cinobufaginol potently inhibits the activity against human nasopharyngeal carcinoma cell lines with IC₅₀s of 803 μΜ and 1.270 μΜ for CNE-1 and CNE-2Z, respectively.

HY-18980

Rottlerin MAllotoxin; NSC 56346; NSC 94525	PKC Autophagy Apoptosis	Infection Cancer
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation.

HY-N4201

β-Hydroxyisovalerylshikonin	EGFR Src	Cancer
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC₅₀s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.

HY-N2359

Chelerythrine	PKC Bcl-2 Family Apoptosis Autophagy	Cancer Metabolic Disease Inflammation/Immunology
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.

HY-123275A

H-D-Phe-Pip-Arg-pNA hydrochloride	Others	Others
H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform.

HY-N2229

Rhapontigenin	Cytochrome P450 Fungal Bacterial	Cancer Infection Inflammation/Immunology
Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC₅₀ = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.

HY-13821

Epoxomicin BU-4061T	Proteasome Apoptosis	Cancer Inflammation/Immunology
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity.

HY-N2329

Piperlongumine Piplartine	ERK Reactive Oxygen Species Autophagy Apoptosis Bacterial Ferroptosis	Cancer Infection Cardiovascular Disease
Piperlongumine is a natural alkaloid isolated from Piper longum Linn, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.

HY-N6953

Garcinone D	STAT Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners.

HY-N0530

Dryocrassin ABBA Dryocrassin	Influenza Virus Bacterial	Infection
Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. Dryocrassin ABBA exhibits antiviral activity against H5N1 avian influenza virus. Dryocrassin ABBA inhibits the coagulase activity of Staphylococcus aureus vWbp. Dryocrassin ABBA suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.

HY-114936

Piericidin A AR-054	Bacterial ADC Cytotoxin Antibiotic	Cancer Infection Neurological Disease
Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity.

HY-121222

alpha-Bisabolol	Apoptosis	Cancer
alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC₅₀=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells.

HY-16561

Resveratrol trans-Resveratrol; SRT501	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic	Cancer Infection Inflammation/Immunology
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor.

HY-W009310

9-cis-Retinal	Endogenous Metabolite	Others
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with K_ds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids.

HY-N2326

(±)-Anatoxin A fumarate	nAChR	Neurological Disease
(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits K_i values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [³H]-dopamine release from rat striatal synaptosomes (EC₅₀=134 nM).

HY-105231

Bryostatin 1	PKC HIV	Cancer Infection Inflammation/Immunology Neurological Disease
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties.

HY-N0594

Deacetylasperulosidic Acid	Interleukin Related	Inflammation/Immunology
Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice. Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells.

HY-N0551

Wedelolactone	Caspase Lipoxygenase Apoptosis	Cancer Inflammation/Immunology
Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC₅₀~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Anti-cancer, anti-inflammatory, and antioxidant activities.

HY-P0063

Copper tripeptide GHK-Cu	Endogenous Metabolite	Inflammation/Immunology
Copper tripeptide (GHK-Cu), a naturally occurring tripeptide, is first isolated from human plasma, but can be found in saliva and urine. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.

HY-N0166

Gramine Donaxine	Adiponectin Receptor Adrenergic Receptor Reverse Transcriptase	Cancer Infection Metabolic Disease Endocrinology
Gramine (Donaxine) is a natural alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties.

HY-N6711

Equisetin	HIV Integrase	Infection
Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537. Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity. Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria. Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections.

HY-N6002

3'-Hydroxypterostilbene	Apoptosis Autophagy	Cancer
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC₅₀s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.

HY-N6954

Garcinone C	ATM/ATR STAT CDK	Cancer
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia Champ that is used as an anti-inflammatory, analgesia, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

Cat. No.	Product Name

HY-L021P

Natural Product Library Plus

2396 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.

Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.

MCE provides a unique collection of 2396 natural products that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

HY-L021L

Natural Product Like Compound Library

188 compounds

Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.

MCE provides a unique collection of 188 natural product-like compounds that are structurally like Steroids, Tannins, Flavonoids, Quinones, Isoquinolines, etc. This library is an important source of lead compounds for drug discovery.

HY-L021

Natural Product Library

2239 compounds

MCE provides a unique collection of 2239 natural products that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L001V

MCE Bioactive Compound Library	10397 compounds
A unique collection of 10397 bioactive compounds including natural products, enzyme inhibitors, receptor ligands, and drugs for high throughput screening (HTS) and high content screening (HCS).

HY-L056

Terpenoids Library

246 compounds

Terpenoids, also known as isoprenoids, are the most numerous and structurally diverse natural products found in many plants. Terpenoids are divided into monoterpenes, sesquiterpenes, diterpenes, sesterpenes, and triterpenes depending on its carbon units. Several studies, in vitro, preclinical, and clinical have confirmed that this class of compounds displays a wide array of very important pharmacological properties in the fight against cancer, malaria, inflammation, and a variety of infectious diseases. Naturally occurring terpenoids provide new opportunities to discover new drugs with minimum side effects.

MCE designs a unique collection of 246 terpenoid compounds that all come from natural products. MCE Terpenoids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L068

Flavonoids Library

210 compounds

Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc.

MCE offers a unique collection of 210 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

HY-L001

Bioactive Compound Library

9350 compounds

Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype.

MCE owns a unique collection of 9350 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. These can also be used for signal pathway research, drug discovery and drug repurposing, etc.

HY-L001P

Bioactive Compound Library Plus

10397 compounds

MCE owns a unique collection of 10397 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. This library is a useful tool for signal pathway research, drug discovery and drug repurposing, etc.

Bioactive Compound Library Plus, with more powerful screening capability, further complements Bioactive Compound Library (HY-L001) by adding some compounds with low solubility or solution stability (Part B) and some novel, rare or exclusive compounds (Part C) to this library. All those supplementary are supplied in powder form.

HY-L030

Human Endogenous Metabolite Compound Library

761 compounds

The composition of endogenous metabolite compounds is affected by the upstream influence of the proteome and genome as well as environmental factors, lifestyle factors, medication, and underlying disease. Therefore, metabolites have been described as proximal reporters of disease because their abundances in biological specimens are often directly related to pathogenic mechanisms. In more recent years, metabolomics approach has been adopted or suggested to be used in various research areas including drug discovery, neurosciences, agriculture, food and nutrition, and environmental sciences.

MCE owns a unique collection of 761 human endogenous metabolites, all of which are derived from human issues. This library is a powerful tool for metabonomics research and metabolism-related drug discovery.

HY-L006

GPCR/G Protein Compound Library

1234 compounds

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provide a unique collection of 1234 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

HY-L026P

Clinical Compound Library Plus

1469 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication, such as lower risk and less investment. Clinical drugs have confirmed bioactivities, clear mechanisms and high safety that are suitable for drug repurposing.

MCE owns a unique collection of 1469 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc. Clinical Compound Library Plus, with powerful screening capability, further complements Clinical Compound Library (HY-L026) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

HY-L060

Cytoskeleton Compound Library

676 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 676 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

HY-L022P

FDA-Approved Drug Library Plus

2434 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 2434 marketed compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. MCE FDA-Approved Drug Library Plus, with more powerful screening capability, further complements FDA-Approved Drug Library (HY-L022) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

HY-L057

Phenols Library

137 compounds

Phenolic compounds are usually referred to as a diverse group of naturally occurring compounds with multiple medical properties, such as antioxidants, antimicrobial properties. Those compounds are commonly found in food and plants. They have high synthetic, medicinal and industrial values. Polyphenols are compounds with multiple phenolic functionalities. Naturally occurring polyphenols are known to have biological activities for use as drugs, for example, in diseases like AIDS, heart ailments, ulcer formation, bacterial infection, mutagenesis and neural disorders.

MCE offers a unique collection of 137 natural phenol compounds which is a useful tool for drug discovery as an important source of lead compounds.

HY-L033

Peptidomimetic Library

380 compounds

A unique collection of 380 compounds that act as substitutes for peptides in their interaction with receptors for drug discovery.

The library consists of HY-L033 (Part A) and compounds with low solubility or stability (Part B).

HY-L0082V

Nucleoside Mimetics Library 290 compounds

A library of 290 nucleoside mimetics.
HY-L0073V

Antiviral Library 4,842 compounds

A unique collection designed for discovery of new Nucleoside-like antivirals

HY-L058

Glycolysis Compound Library

342 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 342 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L065

Traditional Chinese Medicine Monomer Library

722 compounds

Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Traditional Chinese medicine monomers are active compounds of Chinese Herbal Medicines. Those compounds that are with many medicinal properties such as antioxidant, anti-cancer, anti-bacterial effects may be an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine.

MCE designs a unique collection of 722 compounds that all come from Chinese Herbal Medicines. MCE Traditional Chinese Medicine Monomer Library is a useful tool for discovery new drugs from TCM.

HY-L012

Metabolism/Protease Compound Library

2018 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 2018 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

HY-L064

Glutamine Metabolism Compound Library

335 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 335 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

HY-L053

NMPA-Approved Drug Library

1124 compounds

From target identification to clinical research, traditional drug discovery and development is a time-consuming and costly process, which also bears high risk. Compared with traditional drug discovery, drug repositioning or repurposing, also known as old drugs for new uses can greatly shorten the development cycle and reduce development cost, which has become a new trend of drug development. After undergoing clinical trials, approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety, which can greatly improve the success rate of drug discovery. A number of successes have been achieved, such as metformin for type 2 diabetes and thalidomide for leprosy and multiple myeloma, etc.

MCE provides a unique collection of 1124 China NMPA (National Medical Products Administration) approved compounds, which have undergone extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. MCE NMPA-Approved Drug Library is a good tool for drug repurposing which could dramatically accelerate drug development.

HY-L022

FDA-Approved Drug Library

2277 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 2277 marketed compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. MCE FDA-Approved Drug Library is a good tool for drug repurposing which could dramatically accelerate drug development.

HY-L035P

Drug Repurposing Compound Library Plus

3569 compounds

A unique collection of 3569 compounds that have been marketed or successfully passed through Phases I for high throughput screening (HTS) and high content screening (HCS).

The library consists of HY-L035 (Part A) and compounds with low solubility or stability (Part B).

HY-L035

Drug Repurposing Compound Library	3322 compounds
A unique collection of 3322 compounds that have been marketed or successfully passed through Phases I for high throughput screening (HTS) and high content screening (HCS).

HY-L066

FDA Approved & Pharmacopeial Drug Library

2659 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or retasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs and pharmacopoeia collected compounds have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 2659 compounds from approved institutions such as FDA, EMA, NMPA, PMDA, etc. or pharmacopoeia such as USP, BP, JP, etc. These compounds have well-characterized bioactivities, safety and bioavailability properties. MCE FDA Approved & Pharmacopeial Drug Library is a good tool for drug repurposing which could dramatically accelerate drug development.

HY-L052

Anti-COVID-19 Compound Library

1556 compounds

COVID-19 poses a serious threat to people's health, and it is urgent to develop drugs to treat COVID-19 quickly. The screening of anti-COVID-19 drugs by using the clinical and approved compounds can greatly shorten the research and development cycle. In addition, the virtual screening technology can effectively narrow the scope of screening and improve the screening efficiency in the pre-screening of new drugs.

Taking advantage of our virtual screening, we conduct virtual screening of approved compound library and clinical compound library based on the 3CL protease (PDB ID: 6LU7), Spike Glycoprotein (PDB ID: 6VSB), NSP15 (PDB ID: 6VWW), RDRP, PLPro and ACE2 (Angiotensin Converting Enzyme 2) structure. We design a unique collection of 1556 compounds which may have anti-COVID-19 activity. Anti-COVID-19 Compound Library will be a powerful tool for screening new anti-COVID-19 activity drugs.

HY-L0088V

Life Chemicals 50K Diversity Library

50,240 compounds

Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.

HY-L044

Nucleotide Compound Library 165 compounds

A unique collection of 165 nucleotide compounds used for drug discovery for high throughput screening (HTS) and high content screening (HCS).
HY-L0064V

Ion Channel Library 36,800 compounds

A unique collection of 36,800 diverse compounds intended to specifically target ion channels has been offered.

HY-L0091V

Chemspace Lead-Like Compound Library	981,244 compounds
Chemspace Lead-Like Compound Library contains 981,244 in-Stock lead-like compoundswith favorable physicochemical profiles and high Quantitative Estimation of Drug-likeness.

HY-L043

Lipid Compound Library 182 compounds

A unique collection of 182 lipid compounds used for drug discovery for high throughput screening (HTS) and high content screening (HCS).
HY-L041

Macrocyclic Compound Library 114 compounds

A unique collection of 114 macrocyclic compounds used for drug discovery for high throughput screening (HTS) and high content screening (HCS).
HY-L042

Glycoside Compound Library 94 compounds

A unique collection of 94 glycoside compounds used for drug discovery for high throughput screening (HTS) and high content screening (HCS).

HY-L0059V

Allosteric GPCR Library	14,535 compounds
A sub-library of GPCR Library designed for the discovery of novel allosteric ligands. Allosteric GPCRs Library is a utile starting point for the drug discovery in the field of allosteric GPCR modulators.

HY-L0077V

DNA Library	5,530 compounds
A unique collection of 5,530 compounds designed for identification of new actives against proteins essential for DNA stability. The library comprises compounds with in silico predicted activity against key housekeeping proteins essential for DNA stability.

HY-L040

Diabetes Related Compound Library 408 compounds

A unique collection of 408 diabetes related compounds for high throughput screening (HTS) and high content screening (HCS).
HY-L032V

MCE Fragment Library 8344 compounds

A unique collection of 8344 fragment compounds for high-throughput screening (HTS).

HY-L0081V

Molecular Chaperones Library	2,468 compounds
Molecular Chaperones Library comprises 2,468 synthetic compounds targeting most promising and studied targets: Heat shock proteins (Hsp90, Hsp82, Hsp27), chaperone activity of bc1 complex-like and histone-chaperone ASF1a complex (ASF1-histone interaction).

HY-L0062V

Kinase Hinge Binders Library 22,720 compounds

A unique collection of 22,720 kinase inhibitors targeting ATP binding pocket and designed using ligand-based methods.

HY-L023

Toxins for Antibody-Drug Conjugate Research Library

32 compounds

Antibody-Drug Conjugates (ADCs), a new class of treatment for cancer, are composed with a monoclonal antibody, a linker and a cytotoxic agent also referred to as a payload. To date, several ADCs have received market approval and more than 60 ADCs are currently in clinical trials. ADCs are one of the fastest growing classes of oncology drugs worldwide.

The payload or cytotoxic agent is the most important unit in the ADC. ADC has the capability to kill cancer cell depending on the potency of the payload. MCE provides 32 highly potent cytotoxins that contain auristatin derivatives, maytansinoids, calicheamicin, duocarmycin, pyrrolobenzodiazepines (PBDs), etc.

HY-L022M

FDA-Approved Drug Library Mini

1964 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 1964 marketed compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. The package of this library is 96-well microplate with peelable foil seal, which makes the screening process easier and faster.

HY-L063

Chemical Probe Library

88 compounds

Chemical probes are simply reagents with high potency, selectivity and cell-permeability which play important roles in both fundamental and applied biological research. In their most common application, chemical probes can establish the tractability of a specific target. They are used to interrogate the relationship between a target and its phenotype (biological tractability) as well as an ability to modulate that phenotype using a small molecule. Otherwise, chemical probes also have had a major impact in enabling and accelerating discoveries along the path to pioneer medicines. They have helped to improve the understanding of targets and pathways and have created opportunities for proprietary drug discovery efforts to an extent that would not have been possible otherwise.

MCE provides a unique collection of 88 chemical probes with high potency (at least 100 nM potency), selectivity (at least 10-fold selectivity against any other target) and cell-permeability (at least 10 μM potency). MCE Chemical probe library is a useful tool for target identification and mechanism research.

HY-L0051V

HTS Compound Library	2,115,979 compounds
A unique collection contains 2,115,979 diverse screening compounds for the lead identification via high-throughput screening (HTS) and high content screening (HCS).

HY-L039

Reprogramming Compound Library 1079 compounds

A unique collection of 1079 reprogramming compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L0074V

Aquaporins Library	1,500 compounds
The library was designed to find molecules which target both end-chains of water channels (Aquaporins) AQ1, AQ4, AQ5 monomers and internal central pore of AQ5, which possess same physico-chemical properties as those in AQ1 and AQ4.

HY-L0052V

Advanced Library 493,968 compounds

A unique collection contains 493,968 compounds that have lead-like properties for high-throughput screening (HTS) and high content screening (HCS).

HY-L0055V

Discovery Diversity Set 50

50,240 compounds

Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 50 compose of 50,240 highly diverse compounds produced only within last three years. The two sets do not overlap and deliver a total of 60 thousand compounds. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

HY-L036P

Covalent Screening Library Plus	3483 compounds
A unique collection of 3483 compounds that show irreversible covalent binding with target proteins for high throughput screening (HTS) and high content screening (HCS).

HY-L048

Anti-Fungal Compound Library 145 compounds

A unique collection of 145 bioactive anti-fungal compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L055

Medicine Food Homology Compound Library

429 compounds

Medicine Food Homology (MFH) means that some food themselves are medicines and there is no absolute boundary between them. MFH theory combines the function of food and medicine together scientifically and MFH materials can be used both for food and medicine. Besides nutritional value, MFH materials also have the functions in the prevention and treatment of disease and many other healthcare effects. Food as medicines has many benefits because of their safety while taking drugs will bring inevitable side effect to people. In order to ensure the safe use of functional food, National Health Commission of People's Republic of China made specific provisions on MFH items. More than 100 kinds of widely used MFH materials have been released.

Based on MFH items released by National Health Commission, PRC, MCE carefully designs a unique collection of 429 Medicine Food Homology Compounds with high safety that can be used for high throughput and high content screening for drug discovery.

HY-L0075V

BACE Library	7,171 compounds
The library was designed to find molecules which target Beta-secretase (BACE). Beta-secretase (BACE) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells.

HY-L038

Differentiation Inducing Compound Library 778 compounds

A unique collection of 778 compounds that act as modulators in inducing stem cell differentiation.
HY-L049

Anti-Bacterial Compound Library 612 compounds

A unique collection of 612 bioactive anti-bacterial compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L0054V

Discovery Diversity Set 10

10,560 compounds

Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 10 compose of 10,560 highly diverse compounds produced only within last three years. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

HY-L0087V

Life Chemicals HTS Compound Collection	494,471 compounds
Life Chemicals Collection of small organic molecules for high-throughput screening currently contains 494,471 off-the-shelf products. The Collection is being permanently replenished with de novo designed products having optimal physicochemical parameters for drug discovery.

HY-L0053V

Premium Library	44,685 compounds
A unique collection containsover 44,685 compounds having most favorable molecular propertiesfor the lead identification via high-throughput screening (HTS)and high content screening (HCS).

HY-L026

Clinical Compound Library

1356 compounds

MCE owns a unique collection of 1356 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc.

HY-L0068V

Kynurenine Pathway Library	12,300 compounds
The kynurenine pathway library is composed of 12,300 new potential active compounds for the kynurenine pathway, which, in turn, could be used as convenient and quality starting points for early drug development.

HY-L062

Neurotransmitter Receptor Compound Library

955 compounds

Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.

In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.

MCE designs a unique collection of 955 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

HY-L061

Orally Active Compound Library

1871 compounds

Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration. Thus, oral bioavailability is one of the key considerations in drug design and development. A high oral bioavailability reduces the amount of an administered drug necessary to achieve a desired pharmacological effect and therefore could reduce the risk of side-effects and toxicity. A poor oral bioavailability can result in low efficacy and higher inter-individual variability and therefore can lead to unpredictable response to a drug. Low oral bioavailability in clinical trials is a major reason for drug candidates failing to reach the market.

MCE offers a unique collection of 1871 compounds with confirmed high oral bioavailability. MCE Orally Active Compound Library is a useful tool for discovering new drugs with oral bioavailability.

HY-L0086V

Specs HTS Compounds Library 210,070 compounds

A unique collection contains 210,070 diverse chemical compounds to pharmaceutical and biotechnology scientists for drug discovery.
HY-L037

Antioxidants Compound Library 540 compounds

A unique collection of 540 compounds that act as antioxidants for high throughput screening (HTS) and high content screening (HCS).

HY-L047

Endocrinology Compound Library	638 compounds
A unique collection of 638 bioactive compounds related to endocrinology research for high throughput screening (HTS) and high content screening (HCS).

HY-L0076V

Covalent Screening Library	8,301 compounds
Covalent modifiers have attracted much attention in recent years; over 30% marketed drugs have this mode of action. A set of 8,301 screening compounds bearing “warheads” for covalent target modification has been offered.

HY-L0078V

Epigenetics Library 9,184 compounds

A unique collection of 9,184 compounds focusing to hit on a number of epigenetic targets.

HY-L029

Autophagy Compound Library

984 compounds

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

MCE provides a unique collection of 984 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

HY-L067

Antibiotics Library

408 compounds

Antibiotics are types of antimicrobial products used for the treatment and prevention of bacterial infections. Antibiotics can kill or inhibit bacterial growth. Although the target of an antibiotic is bacteria, some antibiotics also attack fungi and protozoans. However, antibiotics rarely have an effect on viruses. The major mechanism underlying antibiotics is the inhibition or regulation of enzymes involved in cell wall biosynthesis, nucleic acid metabolism and repair, protein synthesis, or disruption of membrane structure. Many of these cellular functions targeted by antibiotics are most active in multiplying cells. Since there is often overlap in these functions between prokaryotic bacterial cells and eukaryotic mammalian cells, it is not surprising that some antibiotics have also been found to be useful as anticancer agents.

MCE supplies a unique collection of 408 antibiotics, including penicillins, cephalosporins, tetracyclines, macrolides, etc. MCE Antibiotics Library is a useful tool for anti-bacterial or anti-cancer drugs discovery.

HY-L0085V

Tubulin Library 3,454 compounds

A library of 3,454 potential tubulins ligands.

HY-L070

Neuroprotective Compopund Library

447 compounds

Neurodegenerative diseases are characterised by progressive dysfunction and death of neurons, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Neuroprotection is an approach to preserve neurons so that neurons cannot be hurt by different pathological factors in neurodegenerative diseases. Neuroprotectors are some agonists and antagonists targeting some key targets in neuroprotactive signal pathways, such as calcium and sodium channel blockers, GABA receptor agonists, NMDA receptor Antagonists, etc. Current neuroprotectors cannot reverse existing damage, but they may protect against further nerve damage and slow down any degeneration of the central nervous system (CNS) and still play important roles in the treatment of neurodegenerative diseases.

MCE offers a unique collections of 447 compounds with potential neuroprotective activities. These compounds mainly act on some key targets in neuroprotetive signal pathways, such as calcium channel, sodium channel, adenosine A1 receptor, etc. MCE Neuroprotective Compopund Library is a useful tool in neuroprotective drug discovery.

HY-L008

JAK/STAT Compound Library

213 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 213 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

HY-L027

Anti-Virus Compound Library

506 compounds

Viruses are much simpler organisms than bacteria, and they are made from protein substances and nucleic acid. Despite the fact that the exact mechanism of infection is extremely specific to each type of virus, the general scheme of infection can be represented in the following manner: A virus is absorbed at the surface of a host cell and then permeates through the membrane, where it releases nucleic acid from its protein protection. Then the viral nucleic acid begins to replicate, and transcription of the viral genome takes place either in the cytoplasm, or in the nucleus of the host cell. As a result of these events, a large amount of viral nucleic acid and protein are made to make new generations of virions. Therefore, one mechanism of action of antiviral drugs is to interfere with the ability of a virus to get into a target cell. A second mechanism of action is to target the processes that synthesize virus components after a virus invades a cell, such as nucleotide or nucleoside analogs.

MCE designs a unique collection of 506 anti-virus compounds that target several viruses, including SARS-CoV, HBV, HCV, HIV, HSV and Influenza Virus. It’s an effective tool for anti-virus drug discovery.

HY-L046

Anti-Cardiovascular Disease Compound Library	697 compounds
A unique collection of 697 bioactive anti-cardiovascular compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L016

Protein Tyrosine Kinase Compound Library

528 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 528 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L069

Anti-Alzheimer’s Disease Compound Library

484 compounds

Alzheimer’s Disease (AD) is a progressive degenerative brain disease which causes mental and physical decline, gradually resulting in death. Despite the significant public health issue that it poses, only few medical treatments have been approved for Alzheimer’s Disease (AD) and these act to control symptoms rather than alter the course of the disease. Discovery of new therapeutic approaches depends on the study of pathology of AD. Recent research findings have led to greater understanding of disease neurobiology in Alzheimer's Disease (AD) and identification of unique targets for drug development. Several important mechanisms have been proposed to explain the underlying pathology of AD, such as Amyloid cascade hypothesis, Tau hypothesis and Cholinergic hypothesis, etc.

MCE offers a unique collection of 484 compounds with anti-Alzheimer’s Disease activities or targeting the unique targets of AD. MCE Anti-Alzheimer’s Disease Compound Library is a useful tool for exploring the mechanism of AD and discovering new drugs for AD.

HY-L0061V

Kinase Library 64,000 compounds

A unique collection of 64,000 phosphorylation kinase inhibitors can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L054

Endoplasmic Reticulum Stress Compound Library

83 compounds

Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer.

MCE Endoplasmic Reticulum Stress Compound Library contains 83 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

HY-L010

MAPK Compound Library

227 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 227 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

HY-L018

TGF-beta/Smad Compound Library

110 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 110 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L036

Covalent Screening Library	799 compounds
A unique collection of 799 compounds that show irreversible covalent binding with target proteins for high throughput screening (HTS) and high content screening (HCS).

HY-L0066V

Protein-Protein Interaction Library	40,640 compounds
A unique collection of 40,640 diverse compounds designed for discovery of novel Protein-Protein Interaction (PPI) inhibitors has been offered.

HY-L051

Ferroptosis Compound Library

429 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

A unique collection of 429 ferroptosis signal pathway related compounds with ferroptosis-inducing or -inhibitory activity. A useful tool to study ferroptosis mechanism as well as related diseases.

HY-L0070V

IDO Targeted Library 1,003 compounds

A unique library of 1,003 diverse compounds targeting IDO.

HY-L028

CNS-Penetrant Compound Library

472 compounds

The blood-brain barrier (BBB) is the complex network of brain microvessels. It protects the brain from the external bloodstream environment and supplies the brain with the required nutrients for normal function. However, blood-brain barrier is also the obstacle to deliver beneﬁcial drugs to treat CNS (central nervous system) diseases or brain tumors, as it has the least permeable capillaries in the entire body due to physical barriers (tight junctions). Therefore, it is crucial to discover drugs which can cross this barrier for the treatment of brain-based diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and epilepsy.

MCE offers a unique collection of 472 compounds with confirmed CNS-Penetrant property. It’s a useful tool for the discovery of drugs used for brain diseases, such as brain tumors, mental disorders, and neurodegenerative diseases.

HY-L032

Fragment Library 8344 compounds

A unique collection of 8344 fragment compounds for traditional lead identification via high-throughput screening (HTS).

HY-L025

Anti-Cancer Compound Library

3975 compounds

Cancer is the second leading cause of death globally and seriously threatens human health. A neoplasm and malignant tumor are other common names for cancer. Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Target therapy, which targets proteins that control how cancer cells grow, divide and spread, plays an important role in cancer treatment. Recent studies mainly focus on targeting the key proteins for cancer surviving, cancer stem cells, the tumor microenvironment, tumor immunology, etc.

MCE designs a unique collection of 3975 anti-cancer compounds that target kinases, cell cycle key components, tumorigenesis related signaling pathways, etc. MCE Anti-cancer compound library is a useful tool for anti-cancer drug screening.

HY-L011

Membrane Transporter/Ion Channel Compound Library

695 compounds

Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.

MCE designs a unique collection of 695 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

HY-L024

Histone Modification Research Compound Library

343 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 343 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

HY-L050

Ubiquitination Compound Library 136 compounds

A unique collection of 136 small molecule modulators with biological activity used for ubiquitination research .

HY-L002

Anti-Infection Compound Library

1379 compounds

An infection occurs when another organism enters a person’s body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. The immune system is an effective barrier against infectious agents.

MCE provides a unique collection of 1379 anti-infective compounds with anti-bacterial, anti-viral, anti-fungal and anti-parasite activities that can be used for drug screening and other research in anti-microbial area.

HY-L0067V

Immuno-Oncology Library 52,935 compounds

A unique collection of 52,935 diverse compounds designed for discovery of novel hits in immuno-oncology therapeutic area has been offered.

HY-L013

Neuronal Signaling Compound Library

1316 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 1316 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

HY-L045

Oxygen Sensing Compound Library 1233 compounds

A unique collection of 1233 oxygen sensing related compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L059

Pyroptosis Compound Library

499 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 499 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signal pathway and can be used in the research of pyroptosis signal pathway and related diseases.

HY-L0071V

JAK/STAT Compound Library 1,390 compounds

JAK/STAT compound Library was designed to be a universal tool to search potential JAK-STAT pathway modulators.

HY-L003

Apoptosis Compound Library

1082 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 1082 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signal pathway and can be used in the research of apoptosis signal pathway and related diseases.

HY-L0083V

Protein Mimetics Library 8,960 compounds

A set of 8,960 compounds targeting alpha-helix and beta-turn domains.

HY-L009

Kinase Inhibitor Library

1493 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 1493 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

HY-L031

Small Molecule Immuno-Oncology Compound Library	234 compounds
A unique collection of 234 bioactive tumor immunology compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L015

PI3K/Akt/mTOR Compound Library

302 compounds

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 302 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

HY-L005

Epigenetics Compound Library

632 compounds

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.

MCE provide a unique collection of 632 epigenetics-related compounds that can be used in the research of the related diseases.

HY-L020

Wnt/Hedgehog/Notch Compound Library

173 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 173 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

HY-L0063V

Allosteric Kinase Library	4,800 compounds
Allosteric kinase inhibition is among the most promising and sensitive deactivation mechanism of kinase activity. A unique collection of 4,800 carefully selected molecules via docking and visual evaluation has been offered.

HY-L034

Anti-Aging Compound Library 2299 compounds

A unique collection of 2299 bioactive anti-aging compounds for high throughput screening (HTS) and high content screening (HCS).

HY-L014

NF-κB Signaling Compound Library

305 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 305 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

HY-L0069V

Serine Hydrolase Library 12,040 compounds

Serine hydrolase library is a library of 12,040 precisely selected compounds able to form covalent bonds with catalytic Serine residue.

HY-L017

Stem Cell Signaling Compound Library

383 compounds

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 383 compounds that can be used for stem cell regulatory and signaling pathway research.

HY-L0080V

Lipoxygenase Library 1,388 compounds

A set of 1,388 Lipoxygenase (LOX) inhibitors designed using docking and 2D similarity search.

HY-L0060V

Lipid GPCR Library	5,632 compounds
A unique collection of 5,632 small molecules targeting the family of eight endothelial differentiation gene (EDG) receptors (S1P1–5 and LPA1–3) which is suitable for Lipid GPCR screening research.

HY-L004

Cell Cycle/DNA Damage Compound Library

928 compounds

DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.

MCE owns a unique collection of 928 cell cycle/DNA damage-related compounds which can be used in the research of the same.

HY-L007

Immunology/Inflammation Compound Library

1676 compounds

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

MCE designs a unique collection of 1676 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

HY-L0084V

RNA Library 8,960 compounds

A library of 8,960 compounds capable of binding to RNA has been offered.

HY-L0079V

Glycomimetic Library	2,718 compounds
A specially synthesized set of 2,718 compounds able to mimic glycosides and their interaction with proteins. The main emphasis of library design was made on drug-like compounds enriched with H-bond donors (possess at least two H-bond donors) and bearing nature-like Fsp3–rich scaffolds with diverse spatial orientation of H-bond donors and different 3D-shapes.

HY-L0065V

CNS Library	55,279 compounds
A unique collection of 55,279 novel small molecules with high CNS MPO (Central Nervous System Multiparameter Optimization) scores. The CNS-active molecules which are able to penetrate blood-brain barrier (BBB) were low polar surface area, low degree of possible hydrogen bond formation and low ClogP values.

Cat. No.	Product Name	Type

HY-N0116

Hematoxylin
Haematoxylin; natural Black 1
Chromogenic Substrates

Hematoxylin is a natural product.
HY-12591A

D-Luciferin
D-(-)-Luciferin; Firefly luciferin
Chromogenic Substrates

D-luciferin is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.
HY-N6646

Safflower red
Carthamin
Dyes

Safflower red, a red pigment, is isolated from safflower and used as a natural antioxidant in the food, cosmetics and clothing industries.

HY-D0821

CY5

Sulfo-Cyanine5

Protein Labeling

Cy5 (Sulfo-Cyanine5) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-D0819

CY5-SE

Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester

Protein Labeling

Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

Cat. No.	Product Name	Type

HY-D0842

Bovine Serum Albumin Albumin bovine serum; BSA	Biochemical Assay Reagents
Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications.

HY-125861

Methyl cellulose
Co-solvents

Methylcellulose is a natural polymer which gels on heating. Methylcellulose is not toxic.

HY-18569

3-Indoleacetic acid Indole-3-acetic acid; 3-IAA	Biochemical Assay Reagents
3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-107799

Castor oil	Co-solvents
Castor oil is a natural triglyceride and a solvent. Castor oil has a laxative effect and induces labor in pregnant females. Castor oil can be used as a solvent, co-solvent, stabilizing agent and polyol for the formation of polymer-nanoparticle composites.

Cat. No.	Product Name	Target	Research Area

HY-P0244

Dermorphin
Opioid Receptor Neurological Disease

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

HY-P1486

Angiotensinogen (1-14), human	Endogenous Metabolite	Cardiovascular Disease
Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.

HY-P1486A

Angiotensinogen (1-14), human TFA	Endogenous Metabolite	Cardiovascular Disease
Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides.

HY-P1212

Cortistatin 14, human, rat CST-14, human, rat	Peptides	Neurological Disease
Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus.

HY-P1577

Dermorphin Analog	Opioid Receptor	Inflammation/Immunology
Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide μ-opioid receptor agonist found in amphibian skin.

HY-P1783A

M2e, human TFA	Influenza Virus	Infection
M2e, human TFA, consisting of the 23 extracellular residues of M2 (the third integral membrane protein of influenza A), has been remarkably conserved in all human influenza A. M2e, human TFA is a valid and versatile vaccine candidate to protect against any strain of human influenza A.

HY-P2315

Human β-defensin-1 HβD-1	Antibiotic Bacterial	Infection
Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria.

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide	Adenylate Cyclase	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).

HY-P0001

Thymus factor X
TFX-Jelfa
Peptides Inflammation/Immunology

Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function.

HY-133026

N-Acetylcarnosine N-Acetyl-L-carnosine	Peptides	Inflammation/Immunology
N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in human cataracts.

HY-P1922

γ-2-MSH (41-58), amide	Peptides	Endocrinology
γ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands.

HY-P0219

Microcystin-LA	Phosphatase	Cancer
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively.

HY-P1259A

PR-39 TFA	Proteasome	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 stimulates angiogenesis and inhibits inflammatory responses by specifically blocking degradation of IkappaBalpha and HIF-1alpha by the proteasome.

HY-P1259

PR-39	Proteasome	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 stimulates angiogenesis and inhibits inflammatory responses by specifically blocking degradation of IkappaBalpha and HIF-1alpha by the proteasome.

HY-P1422

Spadin	Potassium Channel	Neurological Disease
Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice.

HY-P1422A

Spadin TFA	Potassium Channel	Neurological Disease
Spadin TFA, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin TFA binds specifically to TREK-1 with an affinity of 10 nM. Spadin TFA is an efficient antidepressant in mice.

HY-P0063

Copper tripeptide GHK-Cu	Endogenous Metabolite	Inflammation/Immunology
Copper tripeptide (GHK-Cu), a naturally occurring tripeptide, is first isolated from human plasma, but can be found in saliva and urine. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.

Cat. No.	Product Name

HY-K0501

SYBR Green qPCR Master Mix

MCE qPCR Master Mix is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water.
HY-K0200

Magnetic Stand

The MCE Magnetic Stand is optimized for efficient magnetic separation of all types of MCE Magnetic Beads with sample volumes ranging from 10 μL to 15 mL.

HY-K0533

2× High-Fidelity PCR Master Mix
2× High-Fidelity PCR Master Mix is provided as a simple-to-use, stabilized 2× formulation that includes all components for PCR except sample DNA, primers and water.

HY-K0531

2× PCR Master Mix (with Dye)
2× PCR Master Mix (with Dye) is provided as a simple-to-use, stabilized 2× formulation that includes all components for PCR except sample DNA, primers and water, in which bromophenol blue dye is included.

HY-K0523

SYBR Green qPCR Master Mix (No ROX)
SYBR Green qPCR Master Mix (No ROX) is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water, in which no ROX Reference Dye is included.

HY-K0532

2× Fast PCR Master Mix (with Dye)
2× Fast PCR Master Mix (with Dye) is provided as a simple-to-use, stabilized 2× formulation that includes all components for fast PCR except sample DNA, primers and water, in which bromophenol blue dye is included.

HY-K0521

SYBR Green qPCR Master Mix (High ROX)
SYBR Green qPCR Master Mix (High ROX) is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water, in which High ROX Reference Dye is included.

HY-K0522

SYBR Green qPCR Master Mix (Low ROX)
SYBR Green qPCR Master Mix (Low ROX) is provided as a simple-to-use, stabilized 2× formulation that includes all components for qPCR except sample DNA, primers and water, in which Low ROX Reference Dye is included.

Cat. No.	Product Name	Target	Research Area

HY-P9906

Bevacizumab
Anti-Human VEGF, Humanized Antibody
VEGFR Cancer

Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity.

Cat. No.	Product Name	Target	Category

HY-W004500

All-trans-retinal	Endogenous Metabolite	Acids and Aldehydes
All-trans-retinal is a one of the major vitamin A metabolites in the retina. In physiological conditions, all-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal.

HY-N7495

all-trans-Anhydro Retinol Anhydrovitamin A	Endogenous Metabolite	Natural Products
all-trans-Anhydro Retinol (Anhydrovitamin A) is a metabolite of Vitamin A. all-trans-Anhydro Retinol is used in synthetic multivitamin preparations.

HY-107494A

all-trans-4-Oxoretinoic acid All-trans 4-Keto Retinoic Acid	Endogenous Metabolite	Natural Products
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-N0292

Oleuropein	PPAR Apoptosis Aromatase	Terpenoids and Glycosides
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits *aromatase*.

HY-N0716

Berberine natural Yellow 18	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Endogenous Metabolite Antibiotic	Alkaloids
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties.

HY-N0116

Hematoxylin
Haematoxylin; natural Black 1
Others Phenols

Hematoxylin is a natural product.
HY-N6609

Magnocurarine
Others Alkaloids

Magnocurarine a natural compound isolated from Tiliacora racemosa.
HY-136064

4,4'-Dimethoxychalcone
Autophagy Flavonoids

4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties.
HY-N2318

Podocarpic acid
TRP Channel Terpenoids and Glycosides

Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

HY-A0143

Dihomo-γ-linolenic acid All-cis-8,11,14-Eicosatrienoic acid	Endogenous Metabolite	Acids and Aldehydes
Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

HY-17577

Berberine chloride hydrate natural Yellow 18 chloride hydrate	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic	Alkaloids
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.

HY-14649

Retinoic acid Vitamin A acid; All-trans-Retinoic acid; ATRA	RAR/RXR PPAR Endogenous Metabolite Autophagy	Natural Products
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM.

HY-N6046

Kamebakaurin	NF-κB	Natural Products
Kamebakaurin is a natural compound isolated from Isodon japonicus. Kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50.

HY-N0005

Curcumin Diferuloylmethane; natural Yellow 3; Turmeric yellow	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis	Phenols
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities.

HY-N5012

Eurycomanone
Pasakbumin A
Others Natural Products

Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

HY-112542

Nemadectin CL-287088; LL-F28249 α	Parasite Antibiotic	Natural Products
Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity.

HY-N1438

Hydroxygenkwanin 7-O-Methylluteolin	Others	Flavonoids
Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect.

HY-W012653

4'-Methylacetophenone	Others	Natural Products
4′-methylacetophenone can be used as a fragrance material. 4′-Methylacetophenone is wildly occurs in volatile compounds in food and in some natural complex substances (NCS).

HY-N2302

Fucoxanthin All-trans-Fucoxanthin	Others	Natural Products
Fucoxanthin is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.

HY-41404

Piperonylic acid	Cytochrome P450	Acids and Aldehydes
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase.

HY-N0325

DL-Methionine	Parasite	Natural Products
DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills *H. rostochiensis* on potato plants.

HY-108485

Damnacanthal	Src Apoptosis Fungal	Quinones
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56^lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans*.

HY-P0244

Dermorphin
Opioid Receptor Natural Products

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.
HY-P0244A

Dermorphin TFA
Opioid Receptor Phenols

Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

HY-B1960

Canthaxanthin E 161g; All-trans-Canthaxanthin	Reactive Oxygen Species	Terpenoids and Glycosides
Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Tyrosinase	Phenols
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM.

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Tyrosinase	Saccharides and Glycosides Phenols
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM.

HY-18258

Berberine chloride natural Yellow 18 chloride	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic	Alkaloids
Berberine chloride is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.

HY-D0889

Glycylglycine
Endogenous Metabolite Alkaloids Acids and Aldehydes

Glycylglycine is the simplest of all peptides and could function as a gamma-glutamyl acceptor.

HY-W017212

Methyl cinnamate Methyl 3-phenylpropenoate	Tyrosinase Bacterial AMPK	Acids and Aldehydes
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.

HY-113159

Docosapentaenoic acid 22n-3
Endogenous Metabolite Natural Products

Docosapentaenoic acid (22n-3) is a component of phospholipids found in all animal cell membranes.

HY-W017770

Ademetionine disulfate tosylate	Others	Acids and Aldehydes
Ademetionine disulfate tosylate is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver.

HY-107383

Tetrahydrobiopterin Sapropterin	NO Synthase Endogenous Metabolite	Saccharides and Glycosides
Tetrahydrobiopterin is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.

HY-N7039

Mogroside IA-(1-3)-glucopyranoside
Others Saccharides and Glycosides

Mogroside IA-(1-3)-glucopyranoside is isolated from Siraitia grosvenorii.

HY-N2022

Castanospermine	Glucosidase	Alkaloids
Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids).

HY-113325

NADP	Endogenous Metabolite	Natural Products
NADP is nicotinamide adenine dinucleotide phosphate, acting as a key cofactor for electron transfer in the metabolism of all organisms, being alternately oxidized (NADP⁺) and reduced (NADPH).

HY-B0216

Ethynyl Estradiol 17α-Ethynylestradiol; Ethynylestradiol	Estrogen Receptor/ERR Endogenous Metabolite	Steroids
Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.

HY-N0913

Manninotriose	Others	Saccharides and Glycosides
Manninotriose is a novel and important player in the RFO(Raffinose family oligosaccharides) metabolism of red dead deadnettle; potential to improve the side effects of MTX for ALL treatment.

HY-N0915

Melittoside
Others Saccharides and Glycosides Terpenoids and Glycosides

Melittoside is a natural compound.
HY-N0916

Monomelittoside
Danmelittoside
Others Saccharides and Glycosides Terpenoids and Glycosides

Monomelittoside is a natural compound.

HY-B0990

Thiostrepton	Bacterial Antibiotic	Alkaloids
Thiostrepton is a natural cyclic oligopeptide antibiotic, is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class.

HY-113215

Allotetrahydrocortisol 5a-Tetrahydrocortisol	Endogenous Metabolite	Steroids
Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes.

HY-N0853

Alisol A
Alisol-A
Autophagy Steroids

Alisol A is a natural product.
HY-N0149

Salicin
D-(−)-Salicin; Salicoside
COX Saccharides and Glycosides

Salicin is a natural COX inhibitor.
HY-N0935

Ligustrazine hydrochloride
Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride
Others Alkaloids

Ligustrazine (hydrochloride) is a natural product.
HY-N0788

Indaconitine
15-Deoxyaconitine
Others Alkaloids

Indaconitine is a natural product.
HY-N0867

Dodecanoic acid ingenol ester
Others Terpenoids and Glycosides

Dodecanoic acid ingenol ester is a natural compound.
HY-N0787

Cryptochlorogenic acid
4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid
Endogenous Metabolite Phenylpropanoids

Cryptochlorogenic acid is a natural product.
HY-N0426

Alismoxide
(+)-Alismoxide
Others Terpenoids and Glycosides

Alismoxide is a natural product.
HY-N0321

Caftaric acid
trans-Caftaric acid
Others Phenylpropanoids

Caftaric acid is a natural product.
HY-N0410

Daucosterol
Eleutheroside A; β-Sitosterol β-D-glucoside
Others Saccharides and Glycosides Steroids

Daucosterol is a natural sterolin.
HY-N0611

alpha-Boswellic acid
α-Boswellic acid
Others Terpenoids and Glycosides

alpha-Boswellic acid is a natural product.
HY-N0237

Atractyloside A
Others Saccharides and Glycosides Terpenoids and Glycosides

Atractyloside A is a natural TCM reference compound.
HY-N0854

Alisol F
P-glycoprotein Terpenoids and Glycosides

Alisol F is a natural product.
HY-N1765

L-Praziquanamine
(+)-Praziquanamine
Others Alkaloids

L-Praziquanamine is a natural product.
HY-N0941

beta-Mangostin
β-Mangostin
Others Flavonoids

beta-Mangostin is a natural product.
HY-N0866

20-Deoxyingenol
Others Terpenoids and Glycosides

20-Deoxyingenol is a natural compound.

HY-W004260

Arachidic acid Icosanoic acid	Endogenous Metabolite	Acids and Aldehydes
Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue.

HY-N1201

Apigenin 4',5,7-Trihydroxyflavone; Apigenol; C.I. natural Yellow 1	Autophagy Cytochrome P450	Flavonoids
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K_i of 2 μM.

HY-14608

(S)-Glutamic acid (+)-L-Glutamic acid	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Alkaloids Acids and Aldehydes
(S)-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-N0881

Desacetylcinobufagin
Deacetylcinobufagin
Others Steroids

Desacetylcinobufagin is a natural compound used for microbial transformation.
HY-N0853A

Alisol A 24-acetate
Alisol-A 24-acetate; Alisol A 24-monoacetate; Alisol A monoacetate
Others Steroids

Alisol A 24-acetate is a natural product.
HY-N1484

7beta-Hydroxylathyrol
Others Terpenoids and Glycosides

7beta-Hydroxylathyrol is a natural product.
HY-N0457

Cichoric Acid
Cichoric acid; Dicaffeoyltartaric acid
Reactive Oxygen Species Phenylpropanoids

Cichoric Acid, a natural product, is reported to be antioxidative.

HY-14608A

L-Glutamic acid monosodium salt Monosodium glutamate	iGluR Apoptosis Ferroptosis	Alkaloids Acids and Aldehydes
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-N0257

Epimedin A
Others Flavonoids Saccharides and Glycosides

Epimedin A is a natural compound extracted from Herba Epimedii.
HY-B0134

Bestatin
Ubenimex
Aminopeptidase Bacterial Antibiotic Alkaloids Acids and Aldehydes

Bestatin is a natural, broad-spectrum, and competitive aminopeptidase inhibitor.
HY-W012185

(-)-Sparteine
(-)-Lupinidine
Others Alkaloids

(-)-Sparteine is a natural alkaloid isolated from beans.
HY-N0843

Kauniolide
Others Terpenoids and Glycosides

Kauniolide(81066-45-7) is a natural compound.
HY-N0561

Lathyrol
Others Terpenoids and Glycosides

Lathyrol is a natural product, and is used for cancer treatment.
HY-N0433

Astragaloside II
Astrasieversianin VIII
Others Saccharides and Glycosides Terpenoids and Glycosides

Astragaloside II is a natural isolated from Astragalus.
HY-17389

Genipin
(+)-Genipin
Autophagy Terpenoids and Glycosides

Genipin is a natural water soluble crosslinking reagent.

HY-N1377

Nevadensin	Bacterial	Flavonoids
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive.

HY-N4019

Maohuoside A	Others	Saccharides and Glycosides
Maohuoside A, a single compound isolated from the E. koreanum that potently promotes osteogenesis. Maohuoside A enhances the osteogenesis of bone marrow-derived mesenchymal stem cells via bone morphogenetic protein (BMP) and MAPK signaling pathways.

HY-N6903

Geoside
Gein; Eugenyl vicianoside
Others Saccharides and Glycosides Terpenoids and Glycosides

Geoside (Gein) is a natural compound isolated from stevia rebaudiana.
HY-N0696

Sipeimine
Imperialine
Others Alkaloids

Sipeimine is a natural product isolated from Fritillaria ussuriensis.
HY-113268

Biotin sulfone
Endogenous Metabolite Natural Products

Biotin sulfone is first isolated as a natural metabolite of biotin.
HY-N4101

Styraxlignolide F
Others Natural Products

Styraxlignolide F is a natural compoundisolated from Styrax japonica.
HY-B1000A

L-SelenoMethionine
Endogenous Metabolite Apoptosis Alkaloids Acids and Aldehydes

L-SelenoMethionine is a major natural food-form of selenium.
HY-N2476

Adynerin
Others Steroids

Adynerin is a natural steroid found in the herbs of Nerium oleander.
HY-N0213

Peiminine
Verticinone; Raddeanine
Autophagy Alkaloids

Peiminine(Verticinone; Raddeanine) is a natural compound with anti-inflammatory activity.

HY-N0560

Oroxylin A Baicalein 6-methyl ether; 6-Methoxybaicalein	HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease	Flavonoids
Oroxylin A is a natural active flavonoid with strong anticancer effects.

HY-N4234

Angelol K
Others Natural Products

Angelol K is a natural product from Chinese angelica.
HY-Y0585

D-(-)-Mandelic acid
Others Acids and Aldehydes

D-(-)-Mandelic acid is a natural compound isolated from bitter almonds.
HY-N0432

Astragaloside I
Astrasieversianin IV; Cyclosieversioside B
Others Saccharides and Glycosides Terpenoids and Glycosides

Astragaloside I is a natural product isolated from Astragalus.
HY-N0772

Isomangiferin
Influenza Virus Flavonoids Saccharides and Glycosides

Isomangiferin, a natural product, is reported to have antiviral activity.
HY-N0434

Astragaloside III
Others Saccharides and Glycosides Terpenoids and Glycosides

Astragaloside III is a natural product isolated from Astragalus.
HY-N1387

4-Methoxycinnamic acid
Endogenous Metabolite Acids and Aldehydes

4-Methoxycinnamic acid is detected as natural phenylpropanoid in A. preissii.

HY-N0726

Dracorhodin perchlorate Dracohodin perochlorate	Apoptosis	Natural Products
Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product extracted from a natural medicine Dragon's blood. Dracorhodin perchlorate (Dracohodin perochlorate) inhibits cell proliferation, induces cell cycle arrest and apoptosis .

HY-N0046

Notoginsenoside Fe Notoginseng triterpenes; Ginsenoside Mb	Others	Saccharides and Glycosides Terpenoids and Glycosides
Notoginsenoside Fe is a natural compound isolated from Panax japlcus var.

HY-113440

5-Methoxytryptophol
Endogenous Metabolite Natural Products

5-Methoxytryptophol is a natural indole present in the pineal gland.
HY-N3524

Calycanthoside
Others Saccharides and Glycosides

Calycanthoside is a natural compound isolated from Angelica tenuissima.
HY-N0668

Rubusoside
Others Saccharides and Glycosides Terpenoids and Glycosides

Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.

HY-N0156

Oleanolic Acid Oleanic acid; Caryophyllin	Autophagy Endogenous Metabolite HIV	Terpenoids and Glycosides
Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities.

HY-N0879

Pseudobufarenogin
ψ-Bufarenogin
Others Steroids

Pseudobufarenogin is a natural compound extracted from toad species with unknown details.
HY-N1958

Syringaresinol diglucoside
Syringaresinol-di-O-glucoside
Others Saccharides and Glycosides

Syringaresinol diglucoside is a natural compound from bamboo leaves.
HY-N6817

Isoagarotetrol
Others Natural Products

Isoagarotetrol is a natural product isolated from agalwood.
HY-N6907

Dahurinol
Others Natural Products

Dahurinol is a natural compound isolated from Cimicifuga acerina.
HY-N0855

Alisol G
Alisol-G; 25-Anhydroalisol A
Others Terpenoids and Glycosides

Alisol G is a natural product extracted from Rhizoma Alismatis.
HY-N1118

Triptotriterpenic acid A
Abrusgenic acid; Maytenfolic acid
Others Natural Products

Triptotriterpenic acid A is a natural product from Tripterygium wilfordii.
HY-N4325

Onjisaponin Z
Others Saccharides and Glycosides

Onjisaponin Z is a natural product isolated from Radix Polygalae.
HY-N2469

Xylotriose
Others Saccharides and Glycosides

Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor.

HY-N3841

ε-Viniferin epsilon-Viniferin	Cytochrome P450	Phenols
ε-Viniferin, the dimer of Resveratrol and isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant capacity.

HY-21088

3-Amino-2-piperidinone Cyclo-ornithine	Endogenous Metabolite	Natural Products
3-aminopiperidine-2-one is a metabolite from all living organisms. 3-aminopiperidine-2-one is a delta-lactam that is 2-piperidone substituted at position 3 by an amino group.

HY-N0167

Gynostemma Extract Ginsenoside C-Mx1; Gynosaponin I; Gypenoside IX	Endogenous Metabolite	Saccharides and Glycosides Terpenoids and Glycosides
Gynostemma Extract (Ginsenoside C-Mx1) is a natural product.

HY-N0597

Panaxatriol
Others Terpenoids and Glycosides

Panaxatriol is a natural product that can relieve myelosuppression induced by radiation injury.
HY-113293A

Estrone sulfate potassium
Endogenous Metabolite Steroids

Estrone sulfate potassium is a natural endogenous steroid and is an estrogen ester and conjugate.
HY-N0212

Peimine
Verticine; Dihydroisoimperialine
Others Alkaloids

Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.
HY-N1366

Herniarin
7-Methoxycoumarin; Methyl umbelliferyl ether
Others Phenylpropanoids

Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
HY-N2212

Arctigenin 4'-O-β-gentiobioside
Others Saccharides and Glycosides

Arctigenin 4'-O-β-gentiobioside is a natural compound isolated from Arctigenin.
HY-N0796

Procyanidin B2
Proanthocyanidin B2
Reactive Oxygen Species Flavonoids

Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.
HY-N0519

Calycosin
Cyclosin
Apoptosis Flavonoids

Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.
HY-N5027

Oxyberberin
Berlambine; 8-Oxoberberine; Ketoberberine
Others Alkaloids

Berlambine is a natural alkaloid isolated from many plants.
HY-N2285

Fabiatrin
Others Phenylpropanoids

Fabiatrin is a natural product isolated from Przewalskia tangutica.
HY-N2440

Gypenoside A
Others Saccharides and Glycosides Terpenoids and Glycosides

Gypenoside A is a natural compound isolaated from Gynostemma pentaphyllum Makino.
HY-N7257

Glucosinalbate
Others Saccharides and Glycosides

Glucosinalbate is a natural product isolated from Arabidopsis thaliana.
HY-N0476

Wilforlide A
Regelide; Abruslactone A
Others Terpenoids and Glycosides

Wilforlide A is a natural product, separated from the ethanolic extract of tripterygium wilfordii.
HY-N2186

Leucoside
Others Flavonoids

Leucoside is a natural compound isolated from tea seed extract.
HY-N6930

Shikonofuran A
Others Natural Products

Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.
HY-N0210

D-Galactose
D-(+)-Galactose
Endogenous Metabolite Saccharides and Glycosides

D-Galactose is a natural aldohexose and C-4 epimer of glucose.
HY-N6959

Osmundacetone
Others Flavonoids

Osmundacetone is a natural product isolated from Osmundae Rhizoma.
HY-N7522

Salvianolic acid E
Others Phenols Acids and Aldehydes

Salvianolic acid E is a natural compound isolated from Salvia miltiorrhiza.
HY-N6859

Lucidenic acid LM1
Others Terpenoids and Glycosides

Lucidenic acid LM1 is a natural triterpenoid isolated from Ganoderma lucidum.
HY-N0936

Coixol
6-Methoxy-2-benzoxazolinone; 6-MBOA
Others Natural Products

Coixol is a natural product extracted from Coix Lachryma-Jobi var.
HY-N7037

Osthol hydrate
Others Phenylpropanoids

Osthol hydrate is a natural product isolated from F. schottiana.

HY-N0077

Ginkgolic Acid Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid	E1/E2/E3 Enzyme	Phenols
Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

HY-N0871

Ingenol-3,4,5,20-diacetonide
Ingenol 3,4:5,20-bisacetonide
Others Terpenoids and Glycosides

Ingenol-3,4,5,20-diacetonide is a natural compound.
HY-N0900

Cimiracemoside D
Others Saccharides and Glycosides Terpenoids and Glycosides

Cimiracemoside D is a natural product found in Actaea racemosa with unknown details.
HY-N0868

20-O-Acetylingenol-3-angelate
Euphorbia factor Pe1
Others Terpenoids and Glycosides

20-O-Acetylingenol-3-angelate is a natural compound.

HY-N0086

N6-Methyladenosine 6-Methyladenosine; N-Methyladenosine	Endogenous Metabolite Influenza Virus	Alkaloids
N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.

HY-N2286

Kushenol I
Others Flavonoids

Kushenol I is a natural compound isolated from the roots of Sophora flavescens.
HY-N0243

Theaflavin
Influenza Virus Endogenous Metabolite Flavonoids

Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.
HY-N4296

Isosakuranin
Others Flavonoids Saccharides and Glycosides

Isosakuranin is a natural product derived from the fruits of Paliurus ramosissimus.
HY-N0442

5-O-Methylvisammioside
4'-O-β-D-Glucosyl-5-O-methylvisamminol
Others Saccharides and Glycosides

5-O-Methylvisammioside is a natural product isolated from Saposhnikovia Divaricata.
HY-131108

β-Aspartylaspartic acid
Others Natural Products

β-Aspartylaspartic acid is a natural compound found in Asparagus (Asparagus officinalis) Shoots.

HY-12591A

D-Luciferin D-(-)-Luciferin; Firefly luciferin	Others	Natural Products
D-luciferin is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.

HY-N0873

Sagittatoside A
Icariin-A
Others Flavonoids Saccharides and Glycosides

Sagittatoside A is a natural compound isolated from traditional Chinese herb Yinyanghuo (Herba Epimdii).
HY-N6912

Regelidine
Others Natural Products

Regelidine is a natural product isolated from the stems of Tripterygium regelii.
HY-N2161

Apiopaeonoside
Others Phenols Saccharides and Glycosides

Apiopaeonoside is a natural product isolated from the root of Paeonia suffruticosa.
HY-N1155

Theviridoside
Others Saccharides and Glycosides

Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.
HY-N0744

Senkyunolide H
Others Natural Products

Senkyunolide H is a natural compound isolated from Ligusticum chuanxiong Hort.
HY-N0852

Benzoylpaeoniflorin
Others Saccharides and Glycosides Terpenoids and Glycosides

Benzoylpaeoniflorin is a natural product; may treat coronary heart disease by decreasing apoptosis.
HY-N2559

Maltohexaose
Amylohexaose
Endogenous Metabolite Saccharides and Glycosides

Maltohexaose is a natural saccharide, and can be produced from amylose, amylopectin and whole starch.
HY-N6991

11-Deoxymogroside IIIE
Others Saccharides and Glycosides

11-Deoxymogroside IIIE is a natural product isolated from Siraitia grosvenorii.
HY-W016289

Antiarol
3,4,5-Trimethoxyphenol
Others Phenols

Antiarol (3,4,5-Trimethoxyphenol) is a natural compound isolated from Salmaliamalabaricum.
HY-N2089

Ligupurpuroside C
Others Phenylpropanoids Saccharides and Glycosides

Ligupurpuroside C is a natural phenylethanoid glycoside isolated from Kudingcha.
HY-N0260

Epmedin C
Epimedin-C; Baohuoside-VI
Others Flavonoids Saccharides and Glycosides

Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.
HY-N7250

(+)-trans-Isolimonene
Others Terpenoids and Glycosides

(+)-trans-Isolimonene is a natural monoterpene isolated from essential oil.
HY-N0903

Dihydrochelerythrine
12,13-Dihydrochelerythrine
Fungal Alkaloids

Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.
HY-N6915

Mogroside II-A
Others Saccharides and Glycosides Terpenoids and Glycosides

Mogroside II-A is a natural product isolated from Siraitia grosvenorii.
HY-N1234

Smyrindioloside
Others Saccharides and Glycosides

Smyrindioloside is a natural product isolated from the bark of Streblus indicus.
HY-N6874

Ligustrosidic acid
Others Natural Products

Ligustrosidic acid is a natural compound isolated from ligustrum japonicum and ligustrum lucidum.

HY-N0573

Umbelliferone 7-Hydroxycoumarin; Hydrangin; NSC 19790	Endogenous Metabolite Apoptosis	Phenylpropanoids
Umbelliferone, a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.

HY-N1599

16-Epivoacarpine
16-epi-Voacarpine
Others Alkaloids

16-Epivoacarpine is a natural alkaloid isolated from Gelsemium elegans.
HY-N3637

Cotoin
Others Natural Products

Cotoin is a natural product isolated from the stem bark of Garcinia virgate.

HY-B0927

Hydrastine (-)-β-Hydrastine; (1R,9S)-β-Hydrastine	Others	Alkaloids
Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

HY-16059

Arglabin
(+)-Arglabin
NOD-like Receptor (NLR) Terpenoids and Glycosides

Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound.

HY-B1000

Selenomethionine Seleno-DL-methionine; DL-Selenomethionine	Autophagy Endogenous Metabolite	Acids and Aldehydes
Selenomethionine is a naturally occurring amino acid containing selenium, is a common natural food source of selenium.

HY-N4279

Gentisin
Others Natural Products

Gentisin is a natural compound isolated from Gentianae radix (Gentianaceae) with mutagenic activities.

HY-N0056

Isochlorogenic acid A 3,5-Dicaffeoylquinic acid; 3,5-CQA	Reactive Oxygen Species HBV Endogenous Metabolite	Phenylpropanoids
Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with antioxidant and anti-inflammatory activities .

HY-13930

Miquelianin Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Endogenous Metabolite	Flavonoids Saccharides and Glycosides
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.

HY-N0695

Schisantherin B
Gomisin-B; Wuweizi ester-B; Schisantherin-B
Amyloid-β Phenylpropanoids

Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a natural product.
HY-N2200

Precyasterone
Others Steroids

Precyasterone is a natural product isolated from the dried roots of Cyathula capitata.
HY-N0748

Oxypaeoniflorin
Others Saccharides and Glycosides Terpenoids and Glycosides

Oxypaeoniflorin is a natural product derived from Radix Paeoniae Rubra and Radix Paeoniae Alba.
HY-N2446

Kakuol
Fungal Phenols

Kakuol is a natural compound isolated from the rhizomes of Asarum sieboldii. Antifungal activity.

HY-N0902

Dihydrosanguinarine 13,14-Dihydrosanguinarine	Others	Alkaloids
Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal and anticancer activity.

HY-N0874

Sagittatoside B
Others Flavonoids Saccharides and Glycosides

Sagittatoside B is a natural compound isolated from traditional Chinese herb Yinyanghuo (Herba Epimdii).

HY-N1372

(R)-Fangchinoline Thalrugosine; Thaligine	Bacterial Antibiotic	Alkaloids
(R)-Fangchinoline (Thalrugosine), a alkaloids from genus Stephania，exhibits antimicrobial and hypotensive activity. The roots and stems of several plants from genus Stephania are all used as traditional Chinese medicine and have been used for treatment of fever, diarrhea, dyspepsia and urinary disease.

HY-N0859

Schisanhenol
Schizanhenol; Gomisin-K3
Others Phenylpropanoids

Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.

HY-N0007

Bisdemethoxycurcumin Curcumin III; Didemethoxycurcumin	Apoptosis Autophagy	Phenols
Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.

HY-15733

Lucidin
NSC 30546
Others Natural Products

Lucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.

HY-N0870

Ingenol-5,20-acetonide-3-O-angelate Ingenol 5,20-acetonide 3-angelate; Ingenol 3-angelate 5,20-acetonide	Others	Terpenoids and Glycosides
Ingenol-5,20-acetonide-3-O-angelate is a natural compound.

HY-N1944

Nerolidol	Bacterial Fungal Parasite Endogenous Metabolite	Terpenoids and Glycosides
Nerolidol is a natural membrane-active sesquiterpene, with antitumor, antibacterial, antifungal and antiparasitic activity.

HY-N0669

Stevioside
Others Terpenoids and Glycosides

Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana, with anticancer activity.
HY-128387

2,3-Butanediol
Endogenous Metabolite Natural Products

2,3-Butanediol is a butanediol derived from the bioconversion of natural resources.

HY-N6260

4-O-beta-Glucopyranosyl-cis-coumaric acid	Others	Phenylpropanoids Saccharides and Glycosides
4-O-beta-Glucopyranosyl-cis-coumaric acid is a natural compound isolated formn Nelumbo nucifera Gaertn.

HY-N0662

Amentoflavone Didemethyl-ginkgetin	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV	Flavonoids
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects.

HY-N4123

Orcinol gentiobioside
Others Phenols

Orcinol gentiobioside (compound 4) is a natural product isolated from the rhizomes of C. breviscapa.

HY-N0467

Rebaudioside C Dulcoside B	Endogenous Metabolite	Saccharides and Glycosides Terpenoids and Glycosides
Rebaudioside C(Dulcoside B) is used as natural sweeteners to diabetics and others on carbohydrate-controlled diets.

HY-N1276

Secoisolariciresinol Monoglucoside
Others Natural Products

Secoisolariciresinol Monoglucoside is a natural product isolated from the seeds of Linum usitatissimum L..

HY-N0123

Aloin Aloin-A; Barbaloin-A	Others	Quinones Saccharides and Glycosides
Aloin(Aloin-A; Barbaloin-A) is a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities.

HY-N4319

Jasminoside B
Others Natural Products

Jasminoside B is a natural compound isolated from the rhizomes of Asarum sieboldii with immunosuppressive activity.

HY-B0183

Ellagic acid	Casein Kinase Reactive Oxygen Species Endogenous Metabolite	Phenols
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-W008350

(+)-Sparteine
nAChR Alkaloids

(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.

HY-N0182

Fisetin	Sirtuin PPAR TNF Receptor	Flavonoids
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-N4324

cis-p-Menthan-1,8-diol
4-p-Menthan-1,8-diol
Others Terpenoids and Glycosides

cis-p-Menthan-1,8-diol is a natural menthane monoterpenoid.

HY-N0875

IKarisoside A Icarisoside-A; Baohuoside II	Others	Flavonoids Saccharides and Glycosides
IKarisoside A(Icarisoside-A) is a natural compound isolated from Epimedium koreanum (Berberidaceae); has anti-inflammatory properties.

HY-N1428

Citric acid	Apoptosis Bacterial Endogenous Metabolite Antibiotic	Acids and Aldehydes
Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer.

HY-15459

Cabazitaxel XRP6258; RPR-116258A; taxoid XRP6258	Microtubule/Tubulin Autophagy	Natural Products
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-N0860

Schisantherin E
Schizantherin-E
Others Phenylpropanoids

Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.
HY-N6889

Rebaudioside I
Others Saccharides and Glycosides

Rebaudioside I is a natural non-claoric sweetener isolated from S. rebaudiana Morita.
HY-N0571

Purpurin
Fungal Bacterial Antibiotic Quinones

Purpurin is a natural anthraquinone compound from Rubia tinctorum L.. Purpurin has antidepressant-like effects.
HY-N1899

p-Hydroxy-5,6-dehydrokawain
Others Flavonoids

p-Hydroxy-5,6-dehydrokawain is a natural compound isolated from Kawain.

HY-W012980

3-Methylbutanoic acid	Endogenous Metabolite	Acids and Aldehydes
3-Methylbutanoic acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.

HY-N0887

Isoastragaloside I Isoastragaloside-I	Others	Saccharides and Glycosides Terpenoids and Glycosides
Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.

HY-N0125

Diosmetin
Cytochrome P450 Flavonoids

Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-A0210

Cerulenin	Fatty Acid Synthase (FASN) Fungal Antibiotic	Natural Products
Cerulenin, the best known natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus.

HY-N0078

Ginkgolic Acid C13:0 Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid	Others	Phenols
Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S.

HY-N0204

Pulchinenoside A Anemoside A3	Others	Saccharides and Glycosides Terpenoids and Glycosides
Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.

HY-W001963

Pyrrole-2-carboxylic acid
Endogenous Metabolite Alkaloids Acids and Aldehydes

Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov.
HY-N6820

Iristectorin A
Others Flavonoids Saccharides and Glycosides

Iristectorin A, a natural product from Iris tectorum, has anti-cancer activities in breast cancer.
HY-N2114

Sedanolide
Autophagy Natural Products

Sedanolide, a natural compound occurring in edible umbelliferous plants, possesses anti-inflammatory and antioxidant activities.

HY-N6646

Safflower red Carthamin	Others	Flavonoids Saccharides and Glycosides
Safflower red, a red pigment, is isolated from safflower and used as a natural antioxidant in the food, cosmetics and clothing industries.

HY-N0184A

Dipotassium glycyrrhizinate	Virus Protease	Saccharides and Glycosides Terpenoids and Glycosides
Dipotassium glycyrrhizinate is a natural compound, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity.

HY-N0537

Xylose D-(+)-Xylose; (+)-Xylose; Wood sugar	Endogenous Metabolite	Saccharides and Glycosides
Xylose, a natural product, can be catalyzed into xylulose by xylose isomerase, and it is the key step for anaerobic ethanolic fermentation of xylose.

HY-N1502

Carboxyatractyloside Gummiferin	Others	Saccharides and Glycosides Terpenoids and Glycosides
Carboxyatractyloside is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport.

HY-N0140

Ursolic acid Prunol; Urson; Malol	Autophagy Endogenous Metabolite	Terpenoids and Glycosides
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-N0418

Quercitrin Quercetin 3-rhamnoside	Ribosomal S6 Kinase (RSK) Autophagy Reactive Oxygen Species	Flavonoids Saccharides and Glycosides
Quercitrin is a natural compound found in Tartary buckwheat with a potential anti-inflammation effect that is used to treat heart and vascular conditions.

HY-N5128

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside
Others Flavonoids

Apigenin6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside is a natural flavanone compound.
HY-N1318

Salvigenin
Autophagy Flavonoids

Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties.

HY-17583

Griseofulvin	Fungal Apoptosis Antibiotic	Natural Products
Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.

HY-N5098

Arenobufagin 3-hemisuberate
Others Steroids

Arenobufagin 3-hemisuberate is a natural compound as a cardiotonic steroid isolated from the skin of Japanese toad.
HY-N0658

L-Threonine
Endogenous Metabolite Alkaloids Acids and Aldehydes

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.

HY-N0841

Bruceine A Dihydrobrusatol; NSC310616	Parasite Antibiotic	Natural Products
Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.

HY-N2176

S-(+)-Marmesin
(+)-Marmesin; (S)-Marmesin
COX Lipoxygenase Phenylpropanoids

S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.

HY-N7035

Wogonin 7-O-beta-D-glucuronide methyl ester Wogonoside methyl ester	Others	Saccharides and Glycosides
Wogonin 7-O-beta-D-glucuronide methyl ester is a natural compound isolated from Huanglian Jiedutang.

HY-B0183A

Ellagic acid (hydrate)	Casein Kinase	Phenols
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-N0889

Ginkgetin
Others Flavonoids

Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L; effects of anti-inflammation and anticancer have been reported.

HY-N2522

Carboxyatractyloside dipotassium Gummiferin dipotassium	Others	Terpenoids and Glycosides
Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport.

HY-N6067

Primin
Bacterial Natural Products

Primin is a natural product stored in trichomes on leaves and stems of Primula obconica, with antimicrobial and antitumour properties.

HY-N0424

Cycloastragenol Cyclogalagenin; Cyclogalegenin; Cyclogalegigenin	Others	Terpenoids and Glycosides
Cycloastragenol, a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties.

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Parasite Ferroptosis	Natural Products
Dihydroartemisinic acid (Dihydroqinghao acid), isolated as a natural product from Artemisia annua, is a biosynthetic precursor to the antimalarial agent Artemisinin.

HY-N0362

Columbianadin
Apoptosis Phenylpropanoids

Columbianadin, a natural coumarin from, is known to have various biological activities including anti-inflammatory and anti-cancer effects.
HY-N2505

Iristectorigenin A
Others Flavonoids

Iristectorigenin A is a natural isoflavone isolated from B. chinensis rhizomes. Iristectorigenin A shows antioxidant activity.
HY-N1950

Hispidulin
Dinatin
Pim Flavonoids

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-N2392

Kukoamine A	Parasite	Alkaloids
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (K_i, 1.8 μM), with antihypertensive activity.

HY-N1405

Cucurbitacin I
Elatericin B; JSI-124; NSC-521777
STAT JAK Terpenoids and Glycosides

Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
HY-N2842

α-Amyrin acetate
Others Terpenoids and Glycosides

α-Amyrin acetate, a natural triterpenoid, has anti-inflammatory activity, antispasmodic profile and the relaxant effect.
HY-W050154

Kojic acid
Parasite Acids and Aldehydes

Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent.
HY-W010178

4-Methyloctanoic acid
Others Natural Products

4-Methyloctanoic acid is a natural compound mainly responsible for the characteristic goaty sheepy flavour of sheep and goat milk.

HY-N0862

Harringtonine	Influenza Virus	Alkaloids
Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC₅₀ of 0.24 μM.

HY-N0628

Kaempferitrin Lespedin; Lespenephryl	Insulin Receptor	Flavonoids Saccharides and Glycosides
Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.

HY-N0739

Betaine hydrochloride Betaine chloride	Others	Alkaloids
Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.

HY-111911

Xanthocillin X permethyl ether
Others Natural Products

Xanthocillin X permethyl ether is a natural compound isolated from fungal extracts, with Aβ-42 lowering activity.

HY-N2239

6-Methoxykaempferol 3-O-Rutinoside	Others	Flavonoids Saccharides and Glycosides
6-Methoxykaempferol 3-O-Rutinoside is a natural product isolated from the herbs of Pilocarpus pennatifolius.

HY-N3670

Cycloolivil Isoolivil	Others	Phenols
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive tree. Antioxidant and Antiaggregant effects.

HY-N3373

Loganetin	Bacterial	Natural Products
Loganetin is a non-toxic natural product that may be applied in the antibacterial drug development for treating multidrug-resistant Gram negative infections.

HY-N0714

Berbamine	NF-κB Autophagy	Alkaloids
Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.

HY-N2181

Acetylshikonin	Cytochrome P450 AChE	Natural Products
Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin is a non-selective cytochrome P450 inhibitor against all P450s (IC₅₀ values range from 1.4-4.0 μM). Acetylshikonin is an AChE inhibitor and exhibits potent antiapoptosis activity.

HY-N7539

Cognac oil	Others	Natural Products
Cognac oil, mainly found in wine lees, has unique fatty acid profiles, including Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), Oleic acid (8.3%) and other fatty acids. Cognac oil leads to a general increase in the permeation of R6G (Rhodamine 6G) across all the membranes.

HY-N7058

cis-Jasmone	Others	Flavonoids
Cis-Jasmone is a plant-derived natural product. Cis-Jasmone is constitutively released by many flowers and sometimes by leaves as an attractant for pollinators or as a chemical cue for host location by insect flower herbivores. Cis-Jasmone treatment of crop plants not only induces direct defense against herbivores, but also induces indirect defense by releasing VOCs that attract natural enemies.

HY-N1369

Menthol	Others	Natural Products
Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca⁺⁺ currents of neuronal membranes.

HY-N0054

Osthole Osthol; Ostol; NSC 31868	Histamine Receptor Apoptosis Parasite HBV	Phenylpropanoids
Osthole is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H₁ receptor activity. Osthole also suppresses the secretion of HBV in cells.

HY-N0064

Macelignan (+)-Anwulignan; Anwuligan	Bacterial	Phenylpropanoids
Macelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.

HY-N0882

Desacetylcinobufotalin Deacetylcinobufotalin	Apoptosis	Steroids
Desacetylcinobufotalin is a natural compound; apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml.

HY-N0891

Tubeimoside II Tubeimoside-B	Others	Saccharides and Glycosides Terpenoids and Glycosides
Tubeimoside II(Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.

HY-N2033

Chebulinic acid	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Phenols
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-N6069

Raspberry ketone glucoside	Others	Phenols
Raspberry ketone glucoside is a natural product in raspberry fruit. Raspberry ketone glucosidev has the inhibitory effect on the melanin synthesis.

HY-B0923

Danthron Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	AMPK Autophagy Bacterial Virus Protease	Quinones
Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

HY-Y0152

Cinchonine (8R,9S)-Cinchonine; LA40221	Apoptosis Parasite	Alkaloids
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells.

HY-N0398

Sec-O-Glucosylhamaudol	Opioid Receptor	Phenylpropanoids Saccharides and Glycosides
Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect.

HY-N0168

Hesperetin	p38 MAPK Apoptosis Autophagy	Flavonoids
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N0563

Alizarin
Others Quinones

Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings.

HY-N0174

Cryptotanshinone Cryptotanshinon; Tanshinone c	STAT Autophagy	Quinones
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

HY-N0234

Bavachinin 7-O-Methylbavachin; Bavachinin A	Others	Flavonoids
Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity.

HY-N0805

Alisol B 23-acetate 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate	Others	Terpenoids and Glycosides
Alisol B 23-acetate, a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.

HY-N6890

Tarasaponin VI
Others Natural Products

Tarasaponin VI is a natural product isolated from Aralia elata. Tarasaponin VI shows potent inhibitory activity on ethanol absorption.

HY-W012999

Tiglic acid	Endogenous Metabolite	Acids and Aldehydes
Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. Tiglic aci has a role as a plant metabolite.

HY-N6833

Rebaudioside M	Others	Saccharides and Glycosides
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a natural non-calorie sweetener isolated from Stevia rebaudiana Bertoni.

HY-N0033

Poliumoside	Others	Phenylpropanoids Saccharides and Glycosides
Poliumoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM.

HY-N1368A

(+)-Borneol d-Borneol	GABA Receptor Endogenous Metabolite	Terpenoids and Glycosides
(+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC₅₀ of 248 μM.

HY-N0856

Alisol C 23-acetate 23-O-Acetylalisol C; Alisol C monoacetate	Others	Terpenoids and Glycosides
Alisol C 23-acetate, a natural product extracted from Alisma orientale, can significantly and strongly inhibit DTH response after oral administration.

HY-N2622

Oxypeucedanin hydrate (+)-Oxypeucedanin hydrate	Others	Phenylpropanoids
Oxypeucedanin hydrate ((+)-Oxypeucedanin hydrate) is a natural product isolated from D. anethifolia. Prangol exhibits mild toxicity on fibroblasts and parental lymphoma cells.

HY-N2182

Episyringaresinol 4'-O-β-D-glncopyranoside	Others	Phenylpropanoids Saccharides and Glycosides
Episyringaresinol 4'-O-β-D-glncopyranoside (compound 22), isolated from Alhagi sparsifolia Shap, is a natural potential neuroinflammatory inhibitor.

HY-B0433A

Quinine hydrochloride dihydrate	Parasite	Alkaloids
Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.

HY-N0610

trans-Cinnamic acid trans-3-Phenylacrylic acid	Bacterial Endogenous Metabolite	Phenylpropanoids
trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1.

HY-Y0790

Cuminaldehyde	Endogenous Metabolite	Natural Products
Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity.

HY-B0914A

10-Undecenoic acid zinc salt Zinc undecylenate	Fungal Antibiotic	Acids and Aldehydes
10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

HY-W007856

5-Methoxysalicylic acid 5-MeOSA	Others	Acids and Aldehydes
5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine.

HY-W015307

4-Ethyloctanoic acid	Others	Acids and Aldehydes
4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive.

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Reactive Oxygen Species	Alkaloids Acids and Aldehydes
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-N6940

Prosapogenin A Progenin III	Apoptosis	Steroids
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.

HY-N3521

Platycoside G1 Deapi-platycoside E	Others	Saccharides and Glycosides Terpenoids and Glycosides
Platycoside G1, a natural product found in Platycodon grandiflorum, is a triterpenoid saponin. Platycoside G1 has potent antioxidant activities.

HY-N0713

Diosmetin-7-O-β-D-glucopyranoside	Others	Flavonoids
Diosmetin-7-O-β-D-glucopyranoside is a natural product isolated from the flowers of Chrysanthemum morifolium, with antioxidant activity.

HY-W010533

(E)-2-Methyl-2-pentenoic acid
Others Acids and Aldehydes

(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin.

HY-N6862

Lucideric acid A	MMP	Terpenoids and Glycosides
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.

HY-N2338

Cholesterol myristate Cholesteryl myristate; Cholesteryl tetradecanoate	nAChR GABA Receptor Potassium Channel Endogenous Metabolite	Steroids
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

HY-N3033

N-Benzyllinolenamide	FAAH Autophagy	Alkaloids
N-Benzyllinolenamide is a natural macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH) with an IC₅₀ of 41.8 μM.

HY-N7054

Volemitol D-Volemitol	Others	Saccharides and Glycosides
Volemitol (D-Volemitol) is a seven-carbon sugar alcohol that fulfills several important physiological functions in certain species of the genus Primula. Volemitol is the major nonstructural carbohydrate in leaves of all stages of development. Volemitol functions as a photosynthetic product, phloem translocate (phloem-mobile), and storage carbohydrate. Volemitol biosynthesis proceeds by a novel, NADPH-dependent, ketose reductase (sedoheptulose reductase).

HY-N0012

Glycitin Glycitein 7-O-β-glucoside	Influenza Virus Bacterial	Flavonoids
Glycitin is a natural isoflavone isolated from legumes; promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.Glycitin is antibacterial, antiviral and estrogenic.

HY-N0452

Hyperoside	Influenza Virus Fungal	Saccharides and Glycosides Flavonoids
Hyperoside, a natural flavonoid, isolated from Camptotheca acuminate, possesses antifungal, anti-inflammatory, anti-viral, anti-oxidative and anti-apoptotic activities.

HY-N0224

Epigoitrin	Influenza Virus	Alkaloids
Epigoitrin is a natural alkaloid from Isatis indigotica, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling.

HY-N2868

Andropanoside	Others	Saccharides and Glycosides Terpenoids and Glycosides
Andropanoside is a natural product isolated and purified from the herbs of Andrographis paniculata. Andrographis paniculata possesses a protective activity against various liver disorders.

HY-N4068

Glucoraphanin	Reactive Oxygen Species	Saccharides and Glycosides
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-N6860

Lucidenic acid C	MMP	Terpenoids and Glycosides
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.

HY-17434

Boldenone Undecylenate Ba 29038	Androgen Receptor Endogenous Metabolite	Steroids
Boldenone Undecylenate (Ba 29038) is a synthetic steroid which has a similar effect as the natural steroid testosterone; it is frequently used in veterinary medicine, though it is also used in humans.

HY-N0777

Isorhamnetin-3-O-glucoside	Others	Saccharides and Glycosides
Isorhamnetin-3-O-glucoside, a natural compound widely contained in many vegetables and rice, could be metabolized in intestinal microbiota after digestion.

HY-N2370

24-Hydroxycholesterol	iGluR LXR	Steroids
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

HY-14781

Levomefolic acid 5-MTHF	Endogenous Metabolite Reactive Oxygen Species	Acids and Aldehydes
Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.

HY-N0207

Patchouli alcohol	Bacterial	Terpenoids and Glycosides
Patchouli alcohol is a natural tricyclic sesquiterpene extracted from Pogostemon cablin (Blanco) Benth, and exhibits anti-Helicobacter pylori and anti-inflammatory properties.

HY-107324

β-Elemene (-)-β-Elemene; Levo-β-elemene	Apoptosis	Terpenoids and Glycosides
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma wenyujin with an antitumor activity. β-Elemene can induce cell apoptosis.

HY-N7434

N-Nitrosodiethylamine	DNA/RNA Synthesis	Natural Products
N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

HY-N0168A

(Rac)-Hesperetin	p38 MAPK Apoptosis Autophagy	Flavonoids
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N6018

Beta-Eudesmol	TRP Channel	Terpenoids and Glycosides
Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC₅₀ of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1.

HY-N0361

Dihydrocapsaicin	TRP Channel	Alkaloids
Dihydrocapsaicin is a natural capsaicin, acts as a selective TRPV1 agonist, and also increases p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection.

HY-N2487

5-Hydroxy-7-acetoxyflavone
Others Flavonoids

5-Hydroxy-7-acetoxyflavone, an active natural flavone derivative found in various plant sources, modulates several biological activities.

HY-N2561

Seneciphylline N-Oxide	Others	Alkaloids
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae).

HY-121471

Chrysoeriol	Others	Flavonoids
Chrysoeriol, a natural flavonoid extracted from the tropical plant Coronopus didymus, exhibits potent antioxidant activity. Chrysoeriol shows significant inhibition of lipid peroxidation.

HY-N0144

Piperine Bioperine; 1-Piperoylpiperidine	P-glycoprotein Autophagy Endogenous Metabolite	Alkaloids
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC₅₀ value of 61.94±0.054 μg/mL in HeLa cell.

HY-N2840

Allitol Allodulcitol	Others	Natural Products
Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS.

HY-13595

Chrysophanol Chrysophanic acid	EGFR	Quinones
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.

HY-U00450

4-O-Methyl honokiol	PPAR NF-κB	Phenylpropanoids
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research.

HY-N0124

Dioscin Collettiside III; CCRIS 4123	Autophagy Apoptosis	Saccharides and Glycosides Steroids
Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.

HY-N6985

Baccatin III	Others	Natural Products
Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs.

HY-N0370

Bergapten 5-Methoxypsoralen	Cytochrome P450 Autophagy	Phenylpropanoids
Bergapten is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. Bergapten is inhibitory towards mouse and human CYP isoforms.

HY-N4317

Ethoxysanguinarine	Apoptosis	Alkaloids
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting protein phosphatase 2A (CIP2A).

HY-N6017

Bakkenolide A	Others	Natural Products
Bakkenolide A is a natural product extracted from Petasites tricholobus. Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.

HY-N4000

Digitonin	Others	Saccharides and Glycosides
Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin is an natural detergent.

HY-N6965

Kaempferol-3-O-(6'''-trans-p-coumaroyl-2''-glucosyl)rhamnoside	Others	Flavonoids Saccharides and Glycosides
Kaempferol-3-O-(6'''-trans-p-coumaroyl-2''-glucosyl)rhamnoside is a natural antioxidant from herbal medicines.

HY-N1455

Falcarinol Panaxynol; Carotatoxin	HSP	Natural Products
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis.

HY-N1181

Tamarixetin 4'-O-Methyl Quercetin	Endogenous Metabolite	Flavonoids
Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy.

HY-N1283

Seneciphyllinine	Others	Alkaloids
Seneciphyllinine, a pyrrolizidine alkaloid, is isolated from the roots of Gynura japonica. Pyrrolizidine alkaloids are highly hepatotoxic natural chemicals that produce irreversible chronic and acute hepatotoxic effects on human beings.

HY-N0849

Dictamine Dictamnine; Dectamine	Apoptosis Bacterial Fungal	Alkaloids
Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.

HY-N5029

Isofebrifugine	Parasite	Alkaloids
Isofebrifugine, isolated from a Chinese medicinal plant, Chang Shan (Dichroa febrifuga), is a natural quinazolinone alkaloid with important physiological activities and good pharmacological effects. Antimalarial effect.

HY-N7011

Epicorynoxidine	Others	Alkaloids
Epicorynoxidine is a natural alkaloid isolated from the herb Corydalis tashiroi. Epicorynoxidine shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL.

HY-N0163

Magnolol	RAR/RXR PPAR Autophagy Bacterial	Phenylpropanoids
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-N0417

Cucurbitacin E α-Elaterin; α-Elaterine	CDK Autophagy	Terpenoids and Glycosides
Cucurbitacin E is a natural compound which from the climbing stem of Cucumic melo L. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

HY-100580

Asaraldehyde Asaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde	COX	Acids and Aldehydes
Asarylaldehyde is a natural COX-2 inhibitor, which isolated from carrot (Daucus carota L.) seeds significantly inhibits cyclooxygenase II (COX-2) activity at IC₅₀ value 100 μg/mL.

HY-N0737

Harmine hydrochloride Telepathine hydrochloride	DYRK 5-HT Receptor	Alkaloids
Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM.

HY-N7124

Benzyl acetate	Others	Natural Products
Benzyl acetate is a constituent of jasmin and of the essential oils of ylang-ylang and neroli. Natural sources of Benzyl acetate include varieties of flowers like jasmine (Jasminum), and fruits like pear, apple.

HY-N6022

Byakangelicin	Others	Phenylpropanoids
Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones.

HY-N0360

Dihydrotanshinone I	SARS-CoV	Quinones
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-N2445

Flavokawain C	Apoptosis	Flavonoids
Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells.

HY-13407

Gossypol BL 193	Bcl-2 Family	Phenols
Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N6038

Gartanin	Others	Natural Products
Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells.

HY-N6661

Verbenone (-)-Verbenone	Others	Terpenoids and Glycosides
Verbenone ((-)-Verbenone) is a natural terpene in leaves of the tree, Suregada zanzibariensis Verdc. Verbenone has anti-aggregation pheromone and interrupts the attraction of bark beetles to their aggregation pheromones.

HY-B2114

Escin	Apoptosis	Saccharides and Glycosides Terpenoids and Glycosides
Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.

HY-W002272

Isocytosine	Nucleoside Antimetabolite/Analog	Natural Products
Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA.

HY-111830

Lignin Lignine	Others	Natural Products
Lignin (Lignine) is a natural complex biopolymer with biodegradable and biocompatible. Lignin is the main component of plant cell walls and is a renewable aromatic polymer. Lignin has strongly antioxidant activity.

HY-N4167

3-O-Methylgalangin Galangin 3-methyl ether; 3-Methylgalangin	Others	Flavonoids
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase.

HY-P2031

Phallacidin	Others	Acids and Aldehydes
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. Phallacidin binds filamentous actin (F-actin) like phalloidin (Item No. 18039), but contains a carboxyl group for coupling reactions.

HY-N0139

Troxerutin Trihydroxyethylrutin	NOD-like Receptor (NLR)	Flavonoids Saccharides and Glycosides
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

HY-N0876

Arenobufagin	Others	Steroids
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.

HY-N7029

3',4',5',5,7-Pentamethoxyflavone	Others	Flavonoids
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic drugs by inhibition of Nrf2 pathway.

HY-P0219

Microcystin-LA	Phosphatase	Natural Products
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively.

HY-N7117

1,4-Cineole	TRP Channel Endogenous Metabolite	Terpenoids and Glycosides
1,4-Cineole is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.

HY-18569

3-Indoleacetic acid Indole-3-acetic acid; 3-IAA	Endogenous Metabolite	Alkaloids
3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-N6969

Dicentrine	Adrenergic Receptor	Alkaloids
Dicentrine is a natural product isolated from the plant Lindera megaphylla with antihypertensive effect. Dicentrine is an α₁-adrenoceptor antagonist which has effective against human hyperplastic prostates.

HY-N4202

Dihydrorotenone	Mitochondrial Metabolism Apoptosis	Natural Products
Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.

HY-N1472

Levistolide A	Apoptosis	Natural Products
Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. Levistolide A can induce apoptosis via ROS-mediated ER stress pathway.

HY-106950

Fosfructose Diphosphofructose; Esafosfan; FDP	Endogenous Metabolite	Acids and Aldehydes
Fosfructose (Diphosphofructose;Esafosfan;FDP) is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma. It acts by stimulating anaerobic glycolysis which generates adenosine triphosphate under ischemic conditions.

HY-N6850

Calenduloside E	HSP Endogenous Metabolite	Saccharides and Glycosides Terpenoids and Glycosides
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).

HY-125699

Ochratoxin C	Fungal	Phenols
Ochratoxin C is the ethyl ester analog of ochratoxin A, a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant. Ochratoxin C rarely occurs as an initial natural contaminant due to a transformation from ochratoxin A.

HY-N6994

Isoasatone A	Others	Phenylpropanoids
Isoasatone A is a natural product isolated from the plant Heterotropa takaoi M., with anti-insect activity. Isoasatone A againsts S. litura by acting on cytochrome P450 monoxygenases and glutathione transferases.

HY-N4288

4-Methylesculetin	Glutathione Peroxidase	Phenylpropanoids
4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level.

HY-N0737A

Harmine Telepathine	DYRK 5-HT Receptor	Alkaloids
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM.

HY-130993

Isatropolone A	Parasite	Natural Products
Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against *Leishmania donovani* with an IC₅₀ of 0.5 μM.

HY-N2110

Phellopterin	Others	Natural Products
Phellopterin is a natural product isolated from P. trifoliata. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.

HY-N2050

1,3,5,8-Tetrahydroxyxanthone Desmethylbellidifolin	Others	Natural Products
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity.

HY-N5083

Saponarin	Others	Flavonoids
Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake.

HY-W009708

Bis(2-methyl-3-furyl)disulfide	Others	Natural Products
Bis(2-methyl-3-furyl)disulfide, compound (2), is intended to provide a flavoring compound to enhance a natural feeling, a fresh feeling and a milk-rich feeling of a milk-related product.

HY-17510

Gossypol acetic acid (±)-Gossypol-acetic acid; BL 193 (acetic acid)	Bcl-2 Family	Phenols
Gossypol acetic acid ((±)-Gossypol-acetic acid), a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N0819

Raddeanin A	Apoptosis	Terpenoids and Glycosides
Raddeanin A is a natural triterpenoid saponin component of Anemone raddeana, with anti-cancer activities. Raddeanin A exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway.

HY-N7072

Grape seed extract	Others	Natural Products
Grape seed extract is a natural product with various health benefits, including anti-inflammatory effect. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase.

HY-18061

Ochromycinone (Rac)-STA-21	STAT Bacterial	Quinones
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.

HY-N6882

Genistein 8-c-glucoside G8CG	Mitochondrial Metabolism Apoptosis	Saccharides and Glycosides
Genistein 8-c-glucoside (G8CG) is a natural glucoside isolated from flowers of Lupinus luteus L. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces apoptosis.

HY-15731

Estetrol	Estrogen Receptor/ERR Endogenous Metabolite	Natural Products
Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast.

HY-N4093

Astringin trans-Astringin	Others	Saccharides and Glycosides
Astringin (trans-Astringin) is a natural glycoside found in the bark of Picea sitchensis and Picea abies (Norway spruce), in Vitis vinifera cell cultures and in wine. Astringin has potent antioxidant capacity and cancer-chemopreventive activity.

HY-107799

Castor oil	Others	Natural Products
Castor oil is a natural triglyceride and a solvent. Castor oil has a laxative effect and induces labor in pregnant females. Castor oil can be used as a solvent, co-solvent, stabilizing agent and polyol for the formation of polymer-nanoparticle composites.

HY-119412

Biliatresone	Others	Phenylpropanoids
Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model.

HY-W016586

Acivicin AT-125; U-42126	Parasite	Natural Products
Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

HY-119931

2-Hydroxychalcone	Bcl-2 Family Apoptosis NF-κB	Flavonoids
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

HY-12686

5Z-7-Oxozeaenol FR148083; L783279; LL-Z 1640-2	MAP3K VEGFR	Natural Products
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC₅₀s of 8 nM and 52 nM, respectively.

HY-N0723

Neomangiferin	Others	Flavonoids
Neomangiferin is a natural C-glucosyl xanthone isolated from m the dried rhizome of Anemarrhena asphodeloides. Neomangiferin has significant therapeutic effects on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats.

HY-N0295

Protocatechualdehyde Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV	Reactive Oxygen Species Bacterial	Phenylpropanoids
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.

HY-106950A

Fosfructose trisodium Diphosphofructose trisodium; Esafosfan trisodium; FDP trisodium	Endogenous Metabolite	Saccharides and Glycosides
Fosfructose trisodium (Diphosphofructose trisodium;Esafosfan trisodium;FDP trisodium) is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma. It acts by stimulating anaerobic glycolysis which generates adenosine triphosphate under ischemic conditions.

HY-129997

Luteolinidin chloride	Others	Flavonoids
Luteolinidin is a natural deoxyanthocyanidin, isolated from mosses and ferns. Luteolinidin is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.

HY-N4253

Kudinoside D	Others	Natural Products
Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes.

HY-N0836

Jervine 11-Ketocyclopamine	Hedgehog Smo	Alkaloids
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.

HY-N0511

Aristolochic acid B	Others	Natural Products
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo.

HY-128851

Coenzyme A	Endogenous Metabolite	Natural Products
Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives.

HY-77813

Benzyl isothiocyanate	Bacterial Apoptosis Antibiotic	Natural Products
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells.

HY-N4053

Heraclenin	Others	Phenylpropanoids
Heraclenin, a natural furanocoumarin, isolated from the root parts of the plant Prangos pabularia. Heraclenin significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT).

HY-15464

(R)-(-)-Gossypol AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Phenols
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N0211

Cyasterone	EGFR	Steroids
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors.

HY-N2342

Procyanidin C1	Apoptosis	Phenols
Procyanidin C1 is a natural polyphenol, causes DNA damage, cell cycle arrest, and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells.

HY-N4327

Eurycomalactone	NF-κB	Natural Products
Eurycomalactone is a natural product found in Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor, with an IC₅₀ of 0.5 μM. Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.

HY-113046

5-Methyltetrahydrofolic acid 5-Methyl THF	Endogenous Metabolite	Acids and Aldehydes
5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid.

HY-N2491

Deoxyelephantopin	NF-κB	Terpenoids and Glycosides
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling.

HY-18085

Quercetin	PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis	Flavonoids
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

HY-W030319

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate	Others	Phenols
Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection.

HY-N0722

Neochlorogenic acid trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Phenylpropanoids
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N1131

Triacetonamine 2,2,6,6-Tetramethyl-4-piperidone	Others	Alkaloids
Triacetonamine is useful as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine is an artifact of plant and fungal extracts using acetone and ammonium hydroxide or natural occurrence of ammonium salts in various steps of the isolation procedures. TAA is the main component of the pyrolysis oil.

HY-N2375

L-Quebrachitol	Wnt β-catenin	Natural Products
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway.

HY-N1956

Rubiadin-1-methyl ether	NF-κB	Quinones
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.

HY-N2228

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-EGCG-3''-O-ME	Others	Flavonoids
(-)-Epigallocatechin-3-(3''-O-methyl) gallate is a natural product isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells.

HY-N6861

Lucidenic acid B

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