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Cat. No.: HY-N7751

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Isotanshinone II

Name: Isotanshinone II
Brand: MedChemExpress
SKU: HY-N7751
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Isotanshinone II is a natural product that can be isolated from Salvia glutinos. Isotanshinone II can be used to study Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 98249-39-9
Formula: C₁₈H₁₂O₃
Molecular Weight:276.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Isotanshinone II Chemical Structure

CAS No.: 98249-39-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (1)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Isotanshinone II is a natural product that can be isolated from Salvia glutinos. Isotanshinone II can be used to study Alzheimer's disease^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	>20 μM Compound: 12, isotanshinone ii	Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay	[PMID: 17583950]
AGS	IC₅₀	>50 μM Compound: 12, isotanshinone ii	Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]
Hep 3B2	IC₅₀	>20 μM Compound: 12, isotanshinone ii	Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay	[PMID: 17583950]
Hep 3B2	IC₅₀	>50 μM Compound: 12, isotanshinone ii	Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]

Chemical Information

CAS No. 98249-39-9
Molecular Weight 276.29
Formula C₁₈H₁₂O₃
SMILES

O=C(C1=C(C2=C3C=CC4=C2C=CC=C4C)OC=C1C)C3=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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ACS Omega

Investigating the Mechanism of the Fuzheng Huayu Formula in Treating Cirrhosis through Network Pharmacology, Molecular Docking, and Experimental Verification. [Abstract]

2025 Apr 29;10(18):19019-19032. PMID: 40385224

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Samanta K, et al. An Expedite Synthesis of Some Angularly Fused Novel ‘U’‐Shaped Tetracyclic Furophenanthraquinones Simulating ABCD Rings of Isotanshinone‐II[J]. ChemistrySelect, 2021, 6(24): 6006-6010.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Isotanshinone II

1 Cited Publications

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Isotanshinone II

Publications Citing Use of MedChemExpress (MCE) Isotanshinone II