Isotanshinone II
Based on 1 publication(s) in Google Scholar
Isotanshinone II is a natural product that can be isolated from Salvia glutinos. Isotanshinone II can be used to study Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 98249-39-9
- Formula: C18H12O3
- Molecular Weight:276.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Isotanshinone II
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AGS | IC50 |
>20 μM
Compound: 12, isotanshinone ii
|
Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
|
[PMID: 17583950] |
| AGS | IC50 |
>50 μM
Compound: 12, isotanshinone ii
|
Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay
Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay
|
[PMID: 17583950] |
| Hep 3B2 | IC50 |
>20 μM
Compound: 12, isotanshinone ii
|
Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay
|
[PMID: 17583950] |
| Hep 3B2 | IC50 |
>50 μM
Compound: 12, isotanshinone ii
|
Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay
Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay
|
[PMID: 17583950] |
Chemical Information
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CAS No. 98249-39-9
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Molecular Weight 276.29
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Formula C18H12O3
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SMILES
O=C(C1=C(C2=C3C=CC4=C2C=CC=C4C)OC=C1C)C3=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Omega
Investigating the Mechanism of the Fuzheng Huayu Formula in Treating Cirrhosis through Network Pharmacology, Molecular Docking, and Experimental Verification. [Abstract]2025 Apr 29;10(18):19019-19032. PMID: 40385224
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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