1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Ononetin

Ononetin 

Cat. No.: HY-108451
Handling Instructions

Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC50 of 0.3 μM.

For research use only. We do not sell to patients.

Ononetin Chemical Structure

Ononetin Chemical Structure

CAS No. : 487-49-0

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Description

Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC50 of 0.3 μM[1].

IC50 & TargetIC50

TRPM3

0.3 μM (IC50)

In Vitro

Ononetin (1-10 μM) completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones, indicating biological activity towards endogenously expressed TRPM3[1].
Oxidative intermediates of Ononetin may be involved in activating TRPA1, but not in the block of TRPM3 by Ononetin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

258.27

Formula

C₁₅H₁₄O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Ononetin
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HY-108451
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