1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Olvanil

Olvanil  (Synonyms: NE-19550; N-Vanillyloleamide)

Cat. No.: HY-101323 Purity: ≥98.0%
COA Handling Instructions

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.

For research use only. We do not sell to patients.

Olvanil Chemical Structure

Olvanil Chemical Structure

CAS No. : 58493-49-5

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Description

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM[1].

IC50 & Target[1]

TRPV1

0.7 nM (EC50)

In Vitro

Olvanil affects C6 glioma cell proliferation (IC50 value of 5.5 μM)[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Olvanil is one capsaicin analog, which acts as an agonist at the vanilloid receptor. Olvanil may have causes an anxiogenic-like effect. Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats weighing approximately 200 g[3]
Dosage: 0, 0.2, 1.0 and 5.0 mg/kg
Administration: Injected intraperitoneally 30 min before the behavioral tests
Result: The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose.
The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively. 
Molecular Weight

417.62

Appearance

Solid

Formula

C26H43NO3

CAS No.
SMILES

CCCCCCCC/C=C\CCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (239.45 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3945 mL 11.9726 mL 23.9452 mL
5 mM 0.4789 mL 2.3945 mL 4.7890 mL
10 mM 0.2395 mL 1.1973 mL 2.3945 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Olvanil
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HY-101323
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