1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Olvanil

Olvanil (Synonyms: NE-19550; N-Vanillyloleamide)

Cat. No.: HY-101323
Handling Instructions

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.

For research use only. We do not sell to patients.

Olvanil Chemical Structure

Olvanil Chemical Structure

CAS No. : 58493-49-5

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Description

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM[1].

IC50 & Target[1]

TRPV1

0.7 nM (EC50)

In Vitro

Olvanil affects C6 glioma cell proliferation (IC50 value of 5.5 μM)[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Olvanil is one capsaicin analog, which acts as an agonist at the vanilloid receptor. Olvanil may have causes an anxiogenic-like effect. Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats weighing approximately 200 g[3]
Dosage: 0, 0.2, 1.0 and 5.0 mg/kg
Administration: Injected intraperitoneally 30 min before the behavioral tests
Result: The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose.
The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively. 
Molecular Weight

417.62

Formula

C₂₆H₄₃NO₃

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Olvanil
Cat. No.:
HY-101323
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