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Halofenozide  (Synonyms: RH-0345)

Cat. No.: HY-113890 Purity: 99.42%
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Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone.

For research use only. We do not sell to patients.

Halofenozide Chemical Structure

Halofenozide Chemical Structure

CAS No. : 112226-61-6

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Based on 1 publication(s) in Google Scholar

Halofenozide Related Antibodies

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Description

Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone[1].

In Vitro

Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Halofenozide Related Antibodies

Cell Viability Assay[2]

Cell Line: Cultured ovaries were dissected from female adult beetles of mealworm, Tenebrio molitor (T. molitor)
Concentration: 1 μM and 10 μM
Incubation Time: 4 days
Result: Did not cause a significant effect on ecdysteroid amounts in the culture medium using ovaries from 0- and 2-day-old females at 10 μM.
Caused a small significant increase of the amounts of ovarian ecdysteroids in the culture medium at 1 μM in the culture medium and with 2-day-old ovaries.
In Vivo

After topical application of Halofenozide (RH-0345; 5 and 10 μg) on adult females, the highest dose (10 μg) reduces significantly the reproductive parameters scored: namely the oviposition period, the fecundity and the egg viability[1].
Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Newly emerged (0-day-old) adult females of T. molitor [1]
Dosage: 5 and 10 μg
Administration: Topically applied
Result: Caused smaller eggs with a decrease in length, width and volume at the two doses tested (5 and 10 μg) .
Molecular Weight

330.81

Formula

C18H19ClN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NN(C(C1=CC=CC=C1)=O)C(C)(C)C)C2=CC=C(Cl)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (377.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0229 mL 15.1144 mL 30.2288 mL
5 mM 0.6046 mL 3.0229 mL 6.0458 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0229 mL 15.1144 mL 30.2288 mL 75.5721 mL
5 mM 0.6046 mL 3.0229 mL 6.0458 mL 15.1144 mL
10 mM 0.3023 mL 1.5114 mL 3.0229 mL 7.5572 mL
15 mM 0.2015 mL 1.0076 mL 2.0153 mL 5.0381 mL
20 mM 0.1511 mL 0.7557 mL 1.5114 mL 3.7786 mL
25 mM 0.1209 mL 0.6046 mL 1.2092 mL 3.0229 mL
30 mM 0.1008 mL 0.5038 mL 1.0076 mL 2.5191 mL
40 mM 0.0756 mL 0.3779 mL 0.7557 mL 1.8893 mL
50 mM 0.0605 mL 0.3023 mL 0.6046 mL 1.5114 mL
60 mM 0.0504 mL 0.2519 mL 0.5038 mL 1.2595 mL
80 mM 0.0378 mL 0.1889 mL 0.3779 mL 0.9447 mL
100 mM 0.0302 mL 0.1511 mL 0.3023 mL 0.7557 mL
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Halofenozide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Halofenozide112226-61-6RH-0345RH0345RH 0345Othersecdysteroidinsectgrowthregulatorhormone 20-hydroxyecdysoneecdysoneOvariesEcdysteroidsMealwormTenebriomolitorInhibitorinhibitorinhibit

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