1. Neuronal Signaling
  2. Amyloid-β
  3. Hoechst 34580 tetrahydrochloride

Hoechst 34580 tetrahydrochloride (Synonyms: HOE 34580 tetrahydrochloride)

Cat. No.: HY-15560B Purity: 99.58%
Handling Instructions

Hoechst 34580 tetrahydrochloride is a cell-permeable fluorescent dye for staining DNA and nuclei.

For research use only. We do not sell to patients.

Hoechst 34580 tetrahydrochloride Chemical Structure

Hoechst 34580 tetrahydrochloride Chemical Structure

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5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
Estimated Time of Arrival: December 31
100 mg USD 408 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Hoechst 34580 tetrahydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Hoechst 34580 tetrahydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hoechst 34580 tetrahydrochloride is a cell-permeable fluorescent dye for staining DNA and nuclei.

IC50 & Target

Amyloid-β[1]

In Vitro

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

597.41

Formula

C27H33Cl4N7

SMILES

CN1CCN(C2=CC=C3C(N=C(C4=CC=C5C(N=C(C6=CC=C(N(C)C)C=C6)N5)=C4)N3)=C2)CC1.[H]Cl.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 2.67 mg/mL (4.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6739 mL 8.3695 mL 16.7389 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Hoechst 34580 tetrahydrochloride
Cat. No.:
HY-15560B
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